1.
J Dtsch Dermatol Ges
; 6(11): 956-8, 2008 Nov.
Artigo
em Inglês, Alemão
| MEDLINE
| ID: mdl-18498378
RESUMO
Two patients with metastatic malignant melanoma developed immediate type hypersensitivity-like symptoms while being treated with recombinant interleukin-(IL-)2 immunotherapy. Both patients showed positive skin prick tests to IL-2, enhanced basophil degranulation in vitro and responded to anti-histamines, but laboratory investigations suggested an IgE-independent, pseudoallergic mast cell degranulation against IL-2.