Corrigendum to "Design and fabrication of high-performance self-setting trimagnesium phosphate" [Bioact. Mater. 28 (2023) 348-357].

[This corrects the article DOI: 10.1016/j.bioactmat.2023.05.019.].

Mg-gallate metal-organic framework-based sprayable hydrogel for continuously regulating oxidative stress microenvironment and promoting neurovascular network reconstruction in diabetic wounds.

Chronic diabetic wounds are the most common complication for diabetic patients. Due to high oxidative stress levels affecting the entire healing process, treating diabetic wounds remains a challenge. Here, we present a strategy for continuously regulating oxidative stress microenvironment by the catalyst-like magnesium-gallate metal-organic framework (Mg-GA MOF) and developing sprayable hydrogel dressing with sodium alginate/chitosan quaternary ammonium salts to treat diabetic wounds. Chitosan quaternary ammonium salts with antibacterial properties can prevent bacterial infection. The continuous release of gallic acid (GA) effectively eliminates reactive oxygen species (ROS), reduces oxidative stress, and accelerates the polarization of M1-type macrophages to M2-type, shortening the transition between inflammation and proliferative phase and maintaining redox balance. Besides, magnesium ions adjuvant therapy promotes vascular regeneration and neuronal formation by activating the expression of vascular-associated genes. Sprayable hydrogel dressings with antibacterial, antioxidant, and inflammatory regulation rapidly repair diabetic wounds by promoting neurovascular network reconstruction and accelerating re-epithelialization and collagen deposition. This study confirms the feasibility of catalyst-like MOF-contained sprayable hydrogel to regulate the microenvironment continuously and provides guidance for developing the next generation of non-drug diabetes dressings.

Bioactive citrate-based polyurethane tissue adhesive for fast sealing and promoted wound healing.

As a superior alternative to sutures, tissue adhesives have been developed significantly in recent years. However, existing tissue adhesives struggle to form fast and stable adhesion between tissue interfaces, bond weakly in wet environments and lack bioactivity. In this study, a degradable and bioactive citrate-based polyurethane adhesive is constructed to achieve rapid and strong tissue adhesion. The hydrophobic layer was created with polycaprolactone to overcome the bonding failure between tissue and adhesion layer in wet environments, which can effectively improve the wet bonding strength. This citrate-based polyurethane adhesive provides rapid, non-invasive, liquid-tight and seamless closure of skin incisions, overcoming the limitations of sutures and commercial tissue adhesives. In addition, it exhibits biocompatibility, biodegradability and hemostatic properties. The degradation product citrate could promote the process of angiogenesis and accelerate wound healing. This study provides a novel approach to the development of a fast-adhering wet tissue adhesive and provides a valuable contribution to the development of polyurethane-based tissue adhesives.

A Gelatin-Based Composite Hydrogel with a "One Stone, Two Birds" Strategy for Photothermal Antibacterial and Vascularization of Infected Wounds.

Bacterial infection, prolonged inflammation, and insufficient angiogenesis are the main challenges for effective wound repair. In this work, we developed a stretchable, remodeling, self-healing, and antibacterial multifunctional composite hydrogel for infected wound healing. The hydrogel was prepared using tannic acid (TA) and phenylboronic acid-modified gelatin (Gel-BA) through hydrogen bonding and borate ester bonds and incorporated iron-containing bioactive glasses (Fe-BGs) with uniform spherical morphologies and amorphous structures to achieve GTB composite hydrogels. On one hand, the chelation of Fe3+ in Fe-BGs with TA endowed the hydrogel with good photothermal synergistic antibacterial ability; on the other hand, the bioactive Fe3+ and Si ions contained in Fe-BGs can recruit cells and synergistically promote blood vessel formation. In vivo animal experiments showed that the GTB hydrogels remarkably accelerated infected full-thickness skin wound healing by improving granulation tissue formation, collagen deposition, and the formation of nerves and blood vessels while decreasing inflammation. This hydrogel with a dual synergistic effect and ″one stone, two birds″ strategy holds immense potential for wound dressing applications.

Design and fabrication of high-performance injectable self-setting trimagnesium phosphate.

Magnesium phosphate bone cement has become a widely used orthopedic implant due to the advantages of fast-setting and high early strength. However, developing magnesium phosphate cement possessing applicable injectability, high strength, and biocompatibility simultaneously remains a significant challenge. Herein, we propose a strategy to develop high-performance bone cement and establish a trimagnesium phosphate cement (TMPC) system. The TMPC exhibits high early strength, low curing temperature, neutral pH, and excellent injectability, overcoming the critical limitations of recently studied magnesium phosphate cement. By monitoring the hydration pH value and electroconductivity, we demonstrate that the magnesium-to-phosphate ratio could manipulate the components of hydration products and their transformation by adjusting the pH of the system, which will influence the hydration speed. Further, the ratio could regulate the hydration network and the properties of TMPC. Moreover, in vitro studies show that TMPC has outstanding biocompatibility and bone-filling capacity. The facile preparation properties and these advantages of TMPC render it a potential clinical alternative to polymethylmethacrylate and calcium phosphate bone cement. This study will contribute to the rational design of high-performance bone cement.

Resource Support for "Mobilization-Participation" in Public Health Emergencies Based on a Complex Network Evolutionary Game.

The organized system of emergency resources with the participation of social subjects features a network, which puts forward new requirements for mobilization policies for public health emergencies. Considering the "mobilization-participation" action of the relationship between the government and social resource subjects and revealing the mechanism of governance measures represent the foundation of developing effective mobilization strategies. To analyze the behavior of subjects in an emergency resource network, this study proposes a framework for the emergency actions of government and social resource subjects, as well as clarifies the functions of relational mechanisms and interorganizational learning in decision making. The game model and its rules of evolution in the network were developed by considering the interventions of rewards and penalties. An emergency resource network was constructed on the basis of a response to the COVID-19 epidemic in a city in China, and a simulation of the "mobilization-participation" game was designed and conducted. We propose a path to promote emergency resource actions by analyzing the initial situations and the interventions' effects. This article suggests that guiding and improving the initial selection of subjects under a certain reward system would be an effective path to facilitate resource support actions during public health emergencies.

Exploring time evolution characteristics of the collaborative mode in emergency information release of public health emergencies: A network analysis of response to COVID-19 from the central government of China.

Emergency information release during public health emergencies is a governance measure to slow down the spread of the epidemic and guide the public in scientific protection. Because of the uncertainty and life-cycle characteristics of public health emergencies, emergency information release represents the process of time dynamics. At present, it is an inevitable trend to establish a collaborative mechanism for emergency information release of public health emergencies to improve the release efficiency and respond to public demand. To determine time evolution characteristics of organizational collaboration in emergency information release, this study took the response to COVID-19 from the central government of China as an example and conducted research based on social network analysis. Based on information from COVID-19-related press conferences held by China's central government, the emergency information release collaborative networks (EIRCNs), and Emergency Organizations-Emergency Information Release Matters (EOs-EIRMs) 2-mode network were constructed. With the time evolution, the tightness, convergence, stability, and connectivity of EIRCNs in public health emergencies presented the process of lowering and then raising. At different stages, the core emergency organization (EO) nodes in EIRCNs continued to maintain a certain degree of activity. Their dynamic processes showed the characteristics of diversification rather than homogeneity. The time evolution of emergency information release matters (EIRMs) reflected the dynamic adjustment of the government's prevention and control measures and responded to the diversification of the public's understanding and protection needs during different stages of the COVID-19 pandemic. The study further examined the driving factors and implementation mechanism of the time evolution characteristics of the collaborative mode of emergency information release. The implementation of EIRMs at different stages had different resource requirements, which were usually achieved by introducing new EOs (Adding resource increment) or increasing the collaborative frequencies among EOs (Activating resource stock). In addition, further research prospects and feasibility interpretation were proposed.

A Study on the Mechanism and Strategy of Cross-Regional Emergency Cooperation for Natural Disasters in China-Based on the Perspective of Evolutionary Game Theory.

Natural disasters have obvious cross-regional and compound characteristics. Cross-regional emergency cooperation for natural disasters deepens the diversification of coordination relations and the complexity of interaction modes among emergency response organizations, including horizontal and vertical organizational interactions. In order to clarify the cooperation mechanism of emergency organizations during cross-regional emergency cooperation for natural disasters and to explore the key factors that affect the cooperative relationships of emergency organizations, in this study, a game model is constructed based on evolutionary game theory, which is composed of local, neighboring, and central governments. Then, the stability of the emergency game strategy is analyzed. On this basis, a numerical simulation is used to simulate the dynamic evolution trajectory of the game system. The results show that there is an embedded mutual promotion mechanism that evolves towards a positive emergency strategy combination among the game subjects. The selection strategies of the game subjects show the characteristics of consistency and the following: enhanced cooperation efficiency between local and neighboring governments, emergency capital stock, and shared resources, therefore, guiding social emergency forces to actively participate in emergency operations. Strengthening the emergency dispatching strength of the central government and the effectiveness of central-local emergency dispatching, can support the performance of cross-regional emergency cooperation for natural disasters. Furthermore, the efficiency of cooperation between local and neighboring governments will be enhanced.

The Expansion Mechanism of the Cooperative Networks of Supply Support Organizations in a Public Health Emergency.

The outbreak of COVID-19 has significantly restricted the productive capacity of society and resulted in a shortage of supplies to maintain survival. Lightening the burden not only depends on government agencies, but also needs extensive social organization participation. However, few studies focus on how to promote social cooperation to support the provision of emergency supplies. This study aimed to find out the theoretical mechanism to expand the cooperative networks of supply support organizations during the epidemic. Data from the emergency response to the COVID-19 pandemic in China were used. Three cooperative networks from a progressive perspective were constructed based on the cooperative relationships among organizations. The expansion mechanism was verified by the exponential random graph model. The results show that when the institutional network expands into an interactive network, the composition of organization types has changed, but the cooperative network's efficiency does not improve much. The matching effect of the organizational type and the Matthew effect of nodes are both effective paths to promote cooperative network expansion, however, the structure effect shows that complex relationship structure is not a critical factor. Our findings highlight the importance of core organizations and the function of different types of organizations in building cooperative network as well as providing theoretical frameworks for policymakers to use in guiding and motivating social cooperation in emergency supplies.