RESUMO
The aim of this study was to explore the role of combined pretreatment serum carbohydrate antigen 19-9 (CA19-9) and neutrophil-to-lymphocyte ratio (NLR) as potential prognostic factors in metastatic pancreatic cancer patients.We investigated pretreatment serum CA19-9 and NLR in 59 metastatic pancreatic cancer patients, determined the patients' thresholds by receiver operating characteristic curve analysis, and assessed their prognostic values by Kaplan-Meier curve and Cox regression models.Results of multivariate analysis showed high CA19-9, high NLR, and high score (the scoring system of CA19-9 and NLR) were significantly correlated with overall survival. Area under the curve of the scoring system was higher than that of CA19-9 or NLR.Combined pretreatment serum CA19-9 and NLR is a better prognostic biomarker of metastatic pancreatic cancer patients than CA19-9 or NLR alone.
Assuntos
Antígeno CA-19-9/sangue , Linfócitos , Neutrófilos , Neoplasias Pancreáticas/sangue , Idoso , Área Sob a Curva , Biomarcadores Tumorais/sangue , Feminino , Humanos , Estimativa de Kaplan-Meier , Contagem de Leucócitos , Contagem de Linfócitos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Neoplasias Pancreáticas/mortalidade , Prognóstico , Modelos de Riscos Proporcionais , Análise de Regressão , Estudos RetrospectivosRESUMO
The purpose of this investigation was to describe the physiological profile of elite, senior Chinese female wrestlers. Twenty-five elite wrestlers, nationally ranked in the top 3 of their weight class, participated in this study. The subjects included Olympic and world champion medalists. The physiological profile included testing of running maximal oxygen consumption (VO2max), 3,200-m run time, 400-m run time, 30-second Wingate anaerobic power and capacity, shoulder, elbow, knee, and trunk isokinetic torque, and 1 repetition maximums (1RMs) in specified exercises. The major results (mean ± SD) were VO2max: 50.58 ± 3.33 ml·kg(-1)·min(-1); 3,200-m run: 14 minutes 1 second ± 49 seconds; 400-m run: 1 minute 11 seconds ± 4 seconds; Wingate maximal anaerobic power: 495.21 ± 79.13 W and mean power: 262.97 ± 52.39 W; 1RM deadlift: 124 ± 19 kg; 1RM deep squat: 98 ± 11 kg; 1RM prone rowing: 72 ± 8 kg; 1RM power clean: 76 ± 12 kg; and 1RM hold and squat: 109 ± 17 kg. In absolute terms in the majority of measures, the heavier weight classes had greater values than the lighter weight classes, but relative to body mass, there were few differences in measures between the weight classes. The Olympic and World Championship medalist had the best value or was at the upper end of a measure's range for the strength and power measures. The results indicate that female wrestling success is not dependent on one physiological characteristic, but that a variety of physiological profiles can result in success. These data on elite female wrestlers can be compared with other wrestlers to help determine individual weaknesses or strengths and to design training programs that result in wrestling success.