The circular RNA circSLC16A10 alleviates diabetic retinopathy by improving mitochondrial function via the miR-761-5p/MFN2 axis.

It has been demonstrated that circular RNAs (circRNAs) are associated with the development of diabetic retinopathy (DR). Nevertheless, the function of circSLC16A10 in the development of DR remains unclear. In order to investigate the role of circSLC16A10, we employed cell and animal models of DR. An analysis of a public database revealed that hsa_circSLC16A10 was expressed at lower levels in DR patients than in diabetic patients without DR or healthy controls. Additionally, the level of hsa_circSLC16A10 was lower in high glucose (HG)-exposed ARPE-19 cells and diabetic mice. hsa_circSLC16A10 was observed to be mainly distributed in the cytoplasm. Moreover, overexpression of hsa_circSLC16A10 alleviated HG-induced endoplasmic reticulum stress and cell apoptosis in vitro. Furthermore, overexpression of hsa_circSLC16A10 ameliorated HG-induced mitochondrial dysfunction, as evidenced by improvements in mitochondrial structure and function. hsa_circSLC16A10 acted as a hsa-miR-761-5p sponge to increase MFN2 expression. MFN2 knockdown or hsa-miR-761-5p overexpression partially reversed the protective effect of hsa_circSLC16A10 in vitro. The protective effect of mmu_circSLC16A10 against DR was confirmed in an animal model of DR. These findings indicate that circSLC16A10 may regulate DR progression by improving mitochondrial function via the miR-761-5p/MFN2 axis.

Three-dimension model of root canal morphology of primary maxillary incisors by micro-computed tomography study.

The success of root canal treatment for deciduous teeth depends upon the shape of the root canal, among other factors. Despite this, there are limited reports on the use of high-resolution micro-CT to describe the root canal morphology of primary maxillary incisors. In this study, we aimed to create a three-dimensional (3D) digital model of the root canal morphology of primary maxillary incisors using microcomputed tomography (micro-CT). To provide a reference for the development of restorative posts for the primary maxillary incisors. Primary maxillary central and lateral incisors (n = 10 each) were analysed. Micro-computed tomography was used to conduct 3D analyses of the root canal system of the primary maxillary incisors. The canal volume and surface area of the primary maxillary central incisors were larger than those of the primary maxillary lateral incisors. The structural model index value was significantly lower in central incisors. At the cervical level and the interface between the cervical and middle one-third cross-sectional levels, the root canals of the primary maxillary lateral incisors were significantly rounder. The labio-palatal dimension and the diameters of the central incisors at the four different levels were significantly smaller than the diameter of the mesio-distal dimension. The taper of the central and lateral incisors gradually increased from the apical one-third to the cervical one-third in the labio-palatal dimension. The data obtained from the 3D analysis of maxillary incisors in this study will contribute to the design of root canal posts.

Does Perceiving the Poor as Warm and the Rich as Cold Enhance Perceived Social Justice? The Effects of Activating Compensatory Stereotypes on Justice Perception.

Compensatory stereotypes are the fundamental components of social perception, and competence and warmth are the two fundamental dimensions of social cognition. Previous studies have concluded that, to maintain belief in justice, the system justification motive leads people to believe that upper- and lower-class groups each have their own unique and mutually offsetting advantages and disadvantages (e.g., the rich have low warmth and the poor have high warmth). The present study introduced the variable of social justice perception (personal and systemic justice perception) and hypothesized that endowing upper-class groups with negative characteristics and lower-class groups with positive characteristics could enhance people's social justice perception. Participants were presented with vignettes that activated compensatory/non-compensatory stereotypes in four ways (compensatory competence, non-compensatory competence, compensatory warmth, non-compensatory warmth) regarding individuals described as rich and poor. Justice perception toward these individuals was then rated by the participants. The results showed that compensatory stereotypes triggered by system justification motives can affect the social justice perceptions of individuals to a certain extent. That is, perceiving the poor as warm and the rich as cold enhances perceived social justice, whereas perceiving the poor as competent and the rich as incompetent reduces perceived personal justice but does not affect perceived systemic justice. Especially in the context of the Chinese Confucian culture, which emphasizes warmth but ignores competence, the effect of compensatory stereotypes on perceptions of social justice underscores a cultural difference with the West that warmth is superior to competence. Further, compensatory stereotypes may be either beneficial for or detrimental to individuals of low socioeconomic status, and the results also question whether justice perception reflects the true fairness of society.

[Research progress of ERIC (IRU)].

Repeat sequence exists in almost all organism genomes. Enterobacterial Repetitive Intergenic Consensus (ERIC), also named Intergenic Repetitive Unit (IRU), is a kind of intergenic repetitive sequence that exists predominantly in Enterobacteria. ERIC (IRU) was firstly discovered in Escherichia coli, followed by identification in many other bacteria. ERIC (IRU) is 127 bp long, and some with inserted sequences. Most ERIC (IRU) can be transcribed, and mRNA forms a stem-loop structure. ERIC (IRU) is restricted to transcribed regions of the genome, either in intergenic regions of polycistronic operons or in untranslated regions upstream or downstream of open reading framesn (ORF). ERIC (IRU) probably modulates the expression of flanking genes. ERIC (IRU) is highly conserved, for either its variation is restricted by the natural selection pressure, or it's "selfish DNA". ERIC-PCR described by Versalovic et al. can efficiently analyze the variation of different ecological systems and monitor the development of microbial flora of the same ecological system. In recent years, this technology has been applied to study the microbial population of animal intestinal tract.