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With the increasing emphasis on sustainability and eco-friendliness, a novel biodegradable packaging materials has received unprecedented attention. Nanocellulose, owing to its high crystallinity, degradability, minimal toxicity, and outstanding biocompatibility, has gained considerable interest in the field of sustainable packaging. This review provided a comprehensive perspective about the recent advances and future development of cellulose nanocrystals (CNCs) and cellulose nanofibers (CNFs). We first introduced the utilization of agricultural waste for nanocellulose production, such as straw, bagasse, fruit byproducts, and shells. Next, we discussed the preparation process of nanocellulose from various agricultural wastes and expounded the advantages and shortcomings of different methods. Subsequently, this review offered an in-depth investigation on the application of nanocellulose in food packaging, especially the function and packaged form of nanocellulose on food preservation. Finally, the safety evaluation of nanocellulose in food packaging is conducted to enlighten and promote the perfection of relevant regulatory documents. In short, this review provided valuable insights for potential research on the biobased materials utilized in future food packaging.
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Reducing the contact time of droplet impacts on surfaces is crucial for various applications including corrosion prevention and anti-icing. This study aims to explore a novel strategy that greatly reduces contact time using a superhydrophobic mesh surface with multiple sets of mutually perpendicular ridges while minimizing the influence of the impacting location. The effects of the impact Weber numbers and ridge spacing on the characteristics of the impact dynamics and contact time are studied experimentally. The experimental results reveal that, for the droplet impact on mesh surfaces, ridges can segment the liquid film into independently multiple-retracting liquid subunits. The retracted subunits provide the upward driving force, which may promote the splashing or pancake bouncing of droplets. At this point, the contact time has a negligible sensitivity for the impacting position and is significantly reduced by up to 68%. Furthermore, the time, dynamic pressure, and energy criteria for triggering splashing and pancake bouncing are proposed theoretically. This work provides an understanding of the mechanism and the design guidelines for effectively reducing the contact time of the impacting droplet on superhydrophobic surfaces.
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The investigation of functional materials derived from sustainable and eco-friendly bioresources has generated significant attention. Herein, nanocomposite films based on chiral nematic cellulose crystals (CNCs) were developed by incorporating xylose and biocompatible ZnO nanoparticles (NPs) via evaporation-induced self-assembly (EISA). The nanocomposite films exhibited iridescent color changes that corresponded to the birefringence phenomenon under polarized light, which was attributed to the formation of cholesteric structures. ZnO nanoparticles were proved to successfully adjust the helical pitches of the chiral arrangements of the CNCs, resulting in tunable optical light with shifted wavelength bands. Furthermore, the nanocomposite films showed fast humidity and ethanol stimuli response properties, exhibiting the potential of stimuli sensors of the CNC-based sustainable materials.
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Celulose , Etanol , Umidade , Nanopartículas , Óxido de Zinco , Celulose/química , Óxido de Zinco/química , Etanol/química , Nanopartículas/química , Nanocompostos/químicaRESUMO
Lignocellulose biorefinery depended on effective pretreatment strategies is of great significance for solving the current global crisis of ecosystem and energy security. This study proposes a novel approach combining seawater hydrothermal pretreatment (SHP) and microwave-assisted deep eutectic solvent (MD) pretreatment to achieve an effective fractionation of Pinus massoniana into high value-added products. The results indicated that complex ions (Mg2+, Ca2+, and Cl-) in natural seawater served as Lewis acids and dramatically promoted the depolymerization of mannose and xylan into oligosaccharides with 40.17 % and 75.43 % yields, respectively. Subsequent MD treatment realized a rapid and effective lignin fractionation (~90 %) while retaining cellulose. As a result, the integrated pretreatment yielded ~85 % of enzymatic glucose, indicating an eightfold increase compared with untreated pine. Because of the increased hydrophobicity induced by the formation of acyl groups during MD treatment, uniform lignin nanospheres were successfully recovered from the DES. It exhibited low dispersibility (PDI = 2.23), small molecular weight (1889 g/mol), and excellent oxidation resistance (RSI = 5.94), demonstrating promising applications in functional materials. The mechanism of lignin depolymerization was comprehensively elucidated via FTIR, 2D-HSQC NMR, and GPC analyses. Overall, this study provides a novel and environmentally friendly strategy for lignocellulose biorefinery and lignin valorization.
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Solventes Eutéticos Profundos , Lignina , Nanosferas , Pinus , Água do Mar , Lignina/química , Pinus/química , Solventes Eutéticos Profundos/química , Água do Mar/química , Nanosferas/química , Açúcares/química , Fermentação , Micro-OndasRESUMO
Progesterone and AdipoQ Receptor 3 (PAQR3) is a member of the AdipoQ receptor. Our previous studies have found that PAQR3 plays a role as a candidate inhibitor in cardiac adenocarcinoma, breast cancer, gastric cancer and colorectal cancer, but the systematic analysis of PAQR3 in tumors is currently lacking. The objective of this study was to investigate the prognostic and therapeutic value of PAQR3 in 31 tumors. Through the analysis of TCGA, UALCAN, GEO, GEPIA2, TIMER, Kaplan-Meier plotter, TISIDB and other databases, it was found that the expression level of PAQR3 changed significantly in different tumor types, and the expression level of Neuroblastoma was very high. And the level of Prostate adenocarcinoma is low. In addition, the expression level of PAQR3 in Cholangiocarcinoma, Esophageal carcinoma, Head and neck squamous carcinoma, Liver Hepatocellular Carcinoma, Lung Adenocarcinoma and Lung squamous cell carcinoma was significantly higher than that in normal tissues. However, the expression level of PAQR3 in Breast Cancer, Kidney Renal Clear Cell Carcinoma, Kidney renal papillary cell carcinoma, Prostate Adenocarcinoma, Rectum Adenocarcinoma, Thyroid Cancer and Uterine Corpus Endometrial Carcinoma was lower than that in normal tissues. Subsequently, we explored the value of PAQR3 as a prognostic indicator of cancer. In Acute Myeloid Leukemia, Lower-grade Glioma and Glioblastoma, Pediatric Low-grade Gliomas, Kidney Chromophobe, and Thyroid Cancer, PAQR3 expression was positively correlated with OS and DSS, while in Rectum Adenocarcinoma, PAQR3 expression was negatively correlated with OS. PAQR3 high expression group Lower-grade Glioma and Glioblastoma, Pediatric Low-grade Gliomas, Uveal Melanoma, Kidney Chromophobe and DFI were positively correlated. PAQR3 can be used as a risk factor for the prognosis of multiple tumors. Then, we discussed the correlation between PAQR3 and immunology, and found that PAQR3 has a wide range of mutations in various tumor types, the most common mutation type is missense mutation, and common mutation types also include amplification, depth deletion, splicing, truncation and structural variation. Among the tumor samples with PAQR3 alterations, mutation occurred in all tumor samples except prostate adenocarcinoma and adrenal cortical carcinoma, head and neck squamous cell carcinoma, brain low-grade glioma, and kidney clear cell carcinoma, while esophageal adenocarcinoma had the highest total alteration frequency. PAQR3 was strongly associated with CNV in 18 tumors, particularly in Ovarian cancer, Lung squamous cell carcinoma, and Adenoid cystic carcinoma. On the other hand, PAQR3 has a higher SNV frequency in Uterine Corpus Endometrial Carcinoma, Skin Cutaneous Melanoma and Lung Adenocarcinoma, among which Uterine Corpus Endometrial Carcinoma has the highest SNV frequency. These results showed that PAQR3 expression levels were significantly correlated with tumor mutation load, microsatellite instability, neoantigens, and purity. In summary, PAQR3 can affect the tumor microenvironment and has potential for chemotherapy. Finally, we investigated the role of PAQR3 in tumor resistance and found that the expression of PAQR3 affects the efficacy of multiple chemotherapy drugs. Based on these studies, we found that PAQR3 plays an important role in cancer and has potential in tumor diagnosis and prognosis.
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Adenocarcinoma de Pulmão , Adenocarcinoma , Neoplasias da Mama , Carcinoma Pulmonar de Células não Pequenas , Carcinoma de Células Renais , Carcinoma de Células Escamosas , Neoplasias do Endométrio , Glioblastoma , Glioma , Neoplasias Renais , Neoplasias Pulmonares , Melanoma , Neoplasias da Próstata , Neoplasias Cutâneas , Neoplasias da Glândula Tireoide , Criança , Feminino , Humanos , Masculino , PrognósticoRESUMO
Sustainable composite hydrogel materials with harsh environmental adaption and tolerance capability have received considerable interests but still remain as challenges. In this work, biomimetic strategy was adapted for construction of three-dimensional galactomannan (GM) hydrogels with intercalation of flexible polymer chains polyethyleneimine (PEI), biomacromolecules tannin acid (TA) and CeO2 nanoparticles (NPs). The hydrogels cross-linked with double-networks (DN) present not only pH-responsive water absorption property, but also boosted mechanical strength with highest toughness of 326 kJ/m3 and Young's modulus of 220 kPa. Self-healing and anti-freezing capabilities were revealed for the hydrogels by maintaining of fracture elongation (23 %) and fracture strength (250 kPa). TA, CeO2 NPs as well as the amide groups in PEI of the hydrogels introduced excellent bacterial prohibition performance on both Bacillus subtilis (B. subtilis) and Escherichia coli (E. coli). Also, due to the existence of the free ions, the hydrogels exhibited electric conductive properties, with wide-range high sensitivity and long-time conductive stability. In addition, various tensile strain degrees were related to the conductive resistance values, and the great recovery performance was proved by cyclic tensile-conductive tests for 3000 times. Therefore, the proposed GM-based hydrogels displayed great potentials as strain sensors that are adaptable and tolerant to various environmental conditions.
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Biomimética , Escherichia coli , Galactose/análogos & derivados , Mananas , Amidas , Condutividade Elétrica , Hidrogéis , PolietilenoiminaRESUMO
In this study, a combination of microcosmic and chemical analysis methods was used to investigate deep eutectic solvent (DES) pretreatment effects on cell wall's micromorphology and lignin's dissolution regular, in order to achieve high-performance biorefinery. The atomic force microscope observed that DES pretreatment peeled off non-cellulose components to reduced "anti-degradation barrier", resulting to improve the enzymatic saccharification from 12.36 % to 90.56 %. In addition, DES pretreatment can break the ß-O-4 bond between the lignin units resulting in a decline in molecular weight from 3187 g/mol to 1112 g/mol (0-6 h). However, long pretreatment time resulted regenerated lignin samples repolymerization. Finally, DES has good recoverability which showed saccharification still can reach 51.51 % at 6 h following four recycling rounds and regenerated lignin also had a typical and well-preserved structure. In general, this work offers important information for industrial biorefinery technologies and lignin valorization.
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Lignina , Populus , Lignina/química , Solventes/química , Solventes Eutéticos Profundos , Biomassa , Hidrólise , Parede CelularRESUMO
Reducing the contact time during the droplet impact on the surface is crucial for anti-icing, self-cleaning, and heat transfer optimization applications. This study aims to minimize the contact time by modifying the surface curvature to create an asymmetric impact process. Our experiments showed that the increase in Weber numbers (We) and the decrease in the ratio of surface diameter to droplet diameter (D*) intensify the asymmetry of the impact process, yielding four distinct rebound modes. Low asymmetry observes the liquid retract toward the central point (Rebound Modes 1 and 2), whereas high asymmetry yields a wing-like rebound (Rebound Modes 3 and 4). In Rebound Mode 1, increased asymmetry would lead to more extended contact due to the prolonged waiting period. Conversely, the reduction in contact time in Rebound Mode 2 occurs due to increased asymmetry with no waiting period. For Rebound Modes 3 and 4, the retraction time could be divided into three stages, generated by two liquid detachment modes from the surface. Analysis reveals that an increased asymmetry would reduce the retraction time during the first stage but prolong it during the third stage, with no significant effects on the second. Four correlations, each pertaining to a distinct impact mode, are proposed based on these analyses to describe the contact time concerning We and D* for droplets impacting a superhydrophobic cylindrical surface.
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Extensive research has shown that a superhydrophobic cylindrical substrate could lead to a noncircumferential symmetry of an impacting droplet, reducing the contact time accordingly. It is of practical significance in applications, such as anti-icing, anticorrosion, and antifogging. However, few accounts have adequately addressed the off-centered impact of the droplet, despite it being more common in practice. This work investigates the dynamic behavior of a droplet off-centered impacting a superhydrophobic cylinder via the lattice Boltzmann method. The effect of the off-centered distance is primarily discussed for droplets taking various Weber numbers and cylinder sizes. The results show that the imposition of an off-center distance can further disrupt the droplet symmetry during the impact. As the off-center distance increases, the droplet movement is gradually tilted toward the offset side until it tangentially passes the cylinder side, resulting in a direct dripping mode. The dynamic features, focusing mainly on maximum spreading in the axial direction and contact time, are specifically explored. A quantitative model of the maximum spreading factor is proposed based on the equivalent transformation from the off-center impact into oblique hitting, considering the full range of off-centered distance. A preliminary contact time model is established for droplet off-centered impacting superhydrophobic cylinders by substituting the maximum spreading and the effective velocity of the liquid moving. This work aims to make an original contribution to the fundamental knowledge of droplet impact and could be of value for related applications.
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Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth, differentiation and function. Amino acid metabolism disorders have been linked with a number of pathological conditions, including metabolic diseases, cardiovascular diseases, immune diseases, and cancer. In the case of tumors, alterations in amino acid metabolism can be used not only as clinical indicators of cancer progression but also as therapeutic strategies. Since the growth and development of tumors depend on the intake of foreign amino acids, more and more studies have targeted the metabolism of tumor-related amino acids to selectively kill tumor cells. Furthermore, immune-related studies have confirmed that amino acid metabolism regulates the function of effector T cells and regulatory T cells, affecting the function of immune cells. Therefore, studying amino acid metabolism associated with disease and identifying targets in amino acid metabolic pathways may be helpful for disease treatment. This article mainly focuses on the research of amino acid metabolism in tumor-oriented diseases, and reviews the research and clinical research progress of metabolic diseases, cardiovascular diseases and immune-related diseases related to amino acid metabolism, in order to provide theoretical basis for targeted therapy of amino acid metabolism.
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Doenças Cardiovasculares , Humanos , Doenças Cardiovasculares/genética , Aminoácidos , Ciclo Celular , Diferenciação Celular , Proliferação de CélulasRESUMO
Anti-ultraviolet material with cost-effectiveness, environmental friendliness, and multifunction is urgently needed to address the serious problem of ultraviolet radiation. However, traditional anti-ultraviolet products based on plastics are unsustainable and harmful to the environment. Herein, the cellulose films with a sandwich structure using a surface assembly technique were reported. Natural L-phenylalanine was grafted onto cellulose nanofibrils via amidation to enhance their UV-shielding property. To address the hydrophilic nature and limited mechanical strength of cellulose films, we employed octadecyltrichlorosilane and 4ARM-PEG-NH2 for hydrophobic coating and mechanical reinforcement, respectively. In addition to providing complete UV resistance in the wavelength range of 200-320 nm, sample OPT5 exhibited significantly improved tensile stress, Young's modulus, and toughness, measuring 174.09 MPa, 71.11 MPa, and 295.33 MJ/m3, respectively. Furthermore, due to the presence of antibacterial amine groups, the modified film demonstrated a satisfactory inhibitory effect on the growth of Escherichia coli and Bacillus subtilis. Compared to natural cellulose films, the hydrophobically modified material achieved a contact angle of up to 121.1°, which enabled efficient separation of oil-water mixtures with a maximum separation efficiency of 93.87 %. In summary, the proposed TOCNF-based UV-shielding film with multifunctionality holds great potential for replacing petrochemical-derived plastics and serving as an applicable and sustainable membrane material.
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Celulose Oxidada , Raios Ultravioleta , Nanopartículas em Multicamadas , Celulose/química , ÁguaRESUMO
Development of amino acid-based natural deep eutectic solvents (DESs) pretreatment technology on lignocellulosic biomass is a promising approach to biorefinery. In this study, for arginine-based DESs with different molar ratios, the viscosity and Kamlet-Taft solvation parameters were quantified to evaluate the pretreatment performance on bamboo biomass. Further, microwave assisted DES pretreatment was eminent, evidenced by 84.8% lignin removal and increased saccharification yield (from 6.3% to 81.9%) in moso bamboo at 120 °C and ratio of 1:7 (arginine: lactic acid). Results showed degradation of lignin molecules together with release of phenolic hydroxyl units after DESs pretreatment, which is conducive to subsequent utilization. Meanwhile, DES-pretreated cellulose exhibited unique structural characteristics including destroyed crystalline region of cellulose (Crystallinity Index from 67.2% to 53.0%), decreased crystallite size (from 3.41 nm to 3.14 nm) and roughened fiber surface. Thus, arginine-based DES pretreatment has excellent potential in bamboo lignocellulose pretreatment.
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Celulose , Lignina , Lignina/química , Solventes Eutéticos Profundos , Micro-Ondas , Arginina , Solventes/química , Hidrólise , BiomassaRESUMO
The development of green and biodegradable nanomaterials is significant for the sustainable utilization of renewable lignocellulosic biomass. This work aimed to obtain the cellulose nanocrystals from quinoa straws (QCNCs) by acid hydrolysis. The optimal extraction conditions were investigated by response surface methodology, and the physicochemical properties of QCNCs were evaluated. The maximum yield of QCNCs (36.58 ± 1.42 %) was obtained under the optimal extraction conditions of 60 % (w/w) sulfuric acid concentration, 50 °C reaction temperature, and 130 min reaction time. The characterization results of QCNCs showed that it is a rod-like material with an average length of 190.29 ± 125.25 nm, an average width of 20.34 ± 4.69 nm, excellent crystallinity (83.47 %), good water dispersibility (Zeta potential = -31.34 mV) and thermal stability (over 200 °C). The addition of 4-6 wt% QCNCs could significantly improve the elongation at break and water resistance of high-amylose corn starch films. This study will pave the route for improving the economic value of quinoa straw, and provide relevant proof of QCNCs for the preliminary application in starch-based composite films with the best performance.
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Chenopodium quinoa , Nanopartículas , Amido/química , Chenopodium quinoa/química , Celulose/química , Água/química , Nanopartículas/químicaRESUMO
Reducing the contact time of a droplet hitting a solid surface is crucial for many situations. In this work, the dynamic behavior of a low-viscosity droplet on a superhydrophobic surface, which consists of a cylindrical substrate and a macro ridge placed axially on the peak, was numerically investigated via the lattice Boltzmann method. The focus was given to the spreading and the detaching morphology of the droplet at the Weber number We = 0.84-37.8 and the cylinder-to-droplet radius ratio R* = 0.57-5.71. The ridge is found to redistribute the droplet mass and affect the impact outcomes, as well as the contact time. For each R*, a jug rebound, a stretched rebound straddling the ridge, and a split detachment occur sequentially with the increasing We. When R* does not exceed 1.71, the contact time decreases continuously with the increase in We. With R* being taken between 1.71 and 5.14, the contact time initially reduces with We and plateaus after We reaches 10.3. Once R* exceeds 5.14, the split droplets may present as a bestriding shape at We > 30.3 rather than the regular jug shape with a small We. The contact time would be decreased to a second plateau in this case. In most cases, the contact time can be shortened effectively for the droplet on a ridged cylinder compared with that of a smooth cylinder.
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Surfactant-assisted pretreatment has been widely reported to improve the enzymatic hydrolysis of lignocellulose by promoting removal of xylan and lignin. Hence, this work innovatively proposed the use of sodium lignosulfonate (SL) as an additive of alkaline pretreatment (AP), and evaluated its influence on the cellulosic digestibility of wheat straw (WS). The results displayed that the maximum of 72-h cellulosic digestibility could reach 83.5% as 15 g/L SL was introduced to the AP process (SAP), while the cellulosic digestibility of hydrothermal and alkaline pretreated WS was only 63.6% and 70.2%, respectively. These increments were subsequently attributed to the improvement of 6.5% xylan and 26.8% lignin accelerated by SAP, resulting in positive changes in structural characteristics such as accessibility, specific surface area, and cellulosic crystalline structure. The utilization of lignin-based surfactants in pretreatment has realized the economic feasibility of lignocellulosic biorefining and broadened the application prospect of surfactants.
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Celulase , Lignina , Lignina/química , Triticum/química , Hidróxido de Sódio , Xilanos , Celulase/química , Tensoativos , HidróliseRESUMO
Nowadays, organic pollutants have been major concerns in many fields. Production of functional materials based on renewable and sustainable resources for organic pollutants detection and removal was of much interest. Herein, multi-functional nanocomposite films based on cellulose nanocrystals (CNCs) with high optical haze, organic pollutant detection and emulsion separation capabilities, have been successfully fabricated based on hydrophobically-modified CNCs suspensions by 2-dodecen-1-succinic anhydride (DDSA) followed by radical polymerization with tridecafluorooctyl (TFMA). The suspensions displayed satisfying oil-in-water emulsion stabilization capabilities and the vacuum-dried films showed birefringence, high transparency, and optical haze (~85 %), due to the ordered arrangements of cellulose nanocrystals. The organic pollutant can be detected through the iridescent colors disappearing by Polarizing Optical Microscope observation. In addition of improved mechanical strength for application (27 MPa) and high contact angle of 131.6°, the hydrophobic films performed as high separation efficiency as >90 % of emulsion, due to the successfully grafting of hydrophobic molecules on the surface of CNCs. Thus, the surface modification for CNCs provide a facile approach of emulsification, pollutants detection and separation properties, which would widen the application potentials of renewable cellulosic resources in fields of environmental protection, engineering control and petroleum industry.
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Nanocompostos , Nanopartículas , Emulsões , Suspensões , Nanopartículas/química , Nanocompostos/química , Celulose/químicaRESUMO
Global energy concerns urged us to search for sufficient utilization of biomass to renewable energy. Herein, rattan biomass displaying herbaceous species-like anatomy and hardwood-like chemical composition was used as model of lignocellulose to determine its recalcitrance inhibiting efficient bioconversion. Delignification and continuous mild alkaline treatments were applied for deconstruction of rattan cane (Calamus simplicifolius) followed by cellulase enzymatic hydrolysis. Cellulose supramolecular structural variations were proved to be the major reason for the enhanced hydrolysis in addition to the removal of lignin and hemicelluloses matrix. Lowered crystallinity (50-65 %) as well as swelled crystallite sizes (4.8-5.0 nm) during allomorphic transformation favored the enhanced hydrolysis, rather than the crystalline cellulose II. Moreover, well-distributed separation and fibrillation of cellulose elementary fibrils also contributed to glucose yield promotion. The study will provide new insights to the strategy to efficient bioconversion of lignocellulosic biomass.
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Celulase , Celulose , Celulose/química , Biomassa , Lignina/química , Glucose/química , Biocombustíveis , HidróliseRESUMO
Microcrystalline celluloses were isolated from four agricultural residues, including sweet sorghum stalk, Jerusalem artichoke stalk, grains stillage, and Chinese herb residue, and characterized in terms of physicochemical and structural properties. The obtained microcrystalline celluloses were composited with polylactic acid as a packing film for the preservation of Lanzhou lily. All the agricultural residues-derived microcrystalline celluloses were in cellulose Iß structure with high purity and good thermal stability. Microcrystalline celluloses from sweet sorghum stalk had a higher degree of polymerization (327) and crystallinity (70.52 %) than others. The preservation effect of lily bulbs packaged by films were significantly improved indicated by the lessened weight loss rate and the meliorative hardness and whiteness, which ascribe to the repressed oxidation reactions. Polylactic acid/microcrystalline cellulose composite films prepared from sweet sorghum straw have been proved the most effective. This work could offer a value-added outlet for agricultural residues to produce microcrystalline celluloses-based biocompatible films for preservation of Lanzhou lily.