Assuntos
Doenças Cardiovasculares/prevenção & controle , Promoção da Saúde , Aspirina/uso terapêutico , Brasil , Medicina Baseada em Evidências , Feminino , Humanos , Hipertensão/prevenção & controle , Metanálise como Assunto , Qualidade de Vida , Ensaios Clínicos Controlados Aleatórios como Assunto , Medição de Risco , Fatores de Risco , Resultado do TratamentoRESUMO
Tecostanine (1) was isolated from Tecoma stans leaves. Its sterochemistry was elucidated as well as its antihyperglycemic activity and its affinity to opioid and nicotinic receptors. The oxalate salt of 1 did not significantly affect blood glucose levels in normoglycaemic and hyperglycaemic rats. It did not appear to interact with opioid receptors (mu type) and showed only moderate affinity to the nicotinic receptor.
Assuntos
Alcaloides/química , Alcaloides/farmacologia , Bignoniaceae/química , Hipoglicemiantes/química , Hipoglicemiantes/farmacologia , Plantas Medicinais/química , Terpenos/química , Terpenos/farmacologia , Animais , Cristalografia por Raios X , Espectroscopia de Ressonância Magnética , Masculino , México , Modelos Moleculares , Conformação Molecular , Ratos , Ratos Sprague-Dawley , Receptores Nicotínicos/efeitos dos fármacos , Receptores Opioides/efeitos dos fármacosRESUMO
Crude extracts of leaves and fruits of Guarea guidona were tested for antiviral activity against pseudorabies virus and foot-and-mouth disease virus in the IB-RS-2 pig cell line and against bovine herpesvirus-1 (BHV-1) in the GBK bovine cell line. The highest nontoxic doses of extracts from fruits and leaves were 125 micrograms/ml and 500 micrograms/ml. respectively. Crude extracts presented antiviral activity against pseudorabies virus with a decrease in virus titer of 3.0 log units at 500 micrograms/ml. Virucidal activity was not observed at 62.5 micrograms/ml. Preformed cell monolayers showed no cytotoxic effect after 48 h in the presence of 500 micrograms/ml in pig cells. G. guidona leaves did not induce an antiviral state but exhibited antiviral effects during the early stage of viral infection.
Assuntos
Antivirais/farmacologia , Aphthovirus/efeitos dos fármacos , Herpesvirus Bovino 1/efeitos dos fármacos , Herpesvirus Suídeo 1/efeitos dos fármacos , Extratos Vegetais/farmacologia , Animais , Bovinos , Linhagem Celular/efeitos dos fármacos , Células Cultivadas , Testes de Sensibilidade Microbiana , Extratos Vegetais/toxicidade , SuínosRESUMO
Crude extracts of leaves and fruits of Guarea guidona were tested antiviral activity against pseudorabies virus and foot-and-mouth disease virus in the IB-RS-2 pig cell line and against bovine herpesvirus-1 (BHV-1) in the GBK bovine Cell line. The highest nontoxic doses of extracts from fruits and leaves were 125 mug/ml and 500 mug/ml, respectively. Crude extracts presented antiviral activity against pseudorabies virus with a decrease in virus titer of 3.0 log units at 500 mug/ml. Virucidal activity was not observed at 62.5 mug/ml. Preformed cell monolayers showed no cytotoxic effect after 48 h in the presence of 500 mug/ml in pig cells. G. guidona leaves did not induce an antiviral state but exhibited antiviral effects during the early stage of viral infection.
Assuntos
Animais , Bovinos , Antivirais/farmacologia , Aphthovirus/efeitos dos fármacos , Herpesvirus Bovino 1/efeitos dos fármacos , Herpesvirus Suídeo 1/efeitos dos fármacos , Extratos Vegetais/farmacologia , Linhagem Celular/efeitos dos fármacos , Células Cultivadas , Testes de Sensibilidade Microbiana , Extratos Vegetais/toxicidade , SuínosRESUMO
Two biflavonoids were isolated from the EtOH extract from leaves of Ouratea spectabilis. Their structures were established to be the novel 6,6"-bigenkwanin and 7,7"-dimethoxyagathisflavone on the basis of spectroscopic data. The inhibition of bovine lens aldose reductase exerted by these biflavones has been studied.
Assuntos
Aldeído Redutase/antagonistas & inibidores , Flavonoides/farmacologia , Cristalino/enzimologia , Plantas Medicinais , Animais , Bovinos , Flavonoides/isolamento & purificação , Cinética , Estrutura Molecular , Folhas de Planta , Relação Estrutura-AtividadeRESUMO
This work describes the utilization of two groups of programs in searching for characteristic signals of NMR 13C of steroidal compounds. The first group of programs used data bases with the spectral data and a methodology that enables the choice and the search of substructures. The chemical shifts and multiplicities for each specific substructure are used as rules to identify different types and subtypes of steroidal compounds. The second one was built to apply the rules formulated by the first group of programs and to foresee any skeletal based on a spectral analysis.
