Influence of Pre-Strain on Static and Fatigue Properties of S420M Steel.

This paper reports the results of static tensile and low-cycle fatigue tests on S420M steel specimens. As-received (unstrained) and pre-strained specimens were used during the tests. Based on the static tensile tests carried out, no effect of pre-strain on the basic strength parameters of the S420M steel was found. Low-cycle fatigue tests showed that the pre-strain of the specimens causes a change in the cyclic properties of the steel and a slight increase in fatigue life compared to that of the as-received specimens. The greatest increase in durability was observed at the lowest strain levels.

High-Frequency Ultrasonography and Evaporimetry in Non-invasive Evaluation of the Nail Unit.

Background: The nail unit (NU) is a complex structure that performs a number of functions, including protection, defense, manipulation, and palpation. Non-invasive research methods can facilitate the recognition of NU structure and function. Evaporimetry and HF-USG due to their availability of equipment and low research costs seem to be particularly noteworthy, but so far have been assessed to a limited extent. The aim of the presented study was to check the usefulness of TOWL and HF-USG in examination of NU. Materials and Methods: A total of 58 volunteers aged 25-65 years (mean age: 41 ± 10.16 years) were qualified for the study. The subjects did not present symptoms of clinically evident onychopathy and did not suffer from any dermatoses associated with lesions occurring within the NU. Additionally, the patients did not suffer from systemic diseases that could affect NU (including heart, lung, and endocrine diseases). In all volunteers, the measurement of TOWL and 20 MHz ultrasonography [high-frequency ultrasonography (HF-USG)] with the special emphasis on determination of nail plate thickness were performed. Results: Analysis of 464 HF-USG images revealed that the nail plate presented as two hyperechoic, parallel streaks (railway sign) with a linear hypoechoic middle layer between them. Matrix was visualized as a hypoechoic structure with blurred boundaries, mostly within the fourth and fifth fingers and more often in women. We found statistically significant correlations between the type of a finger and the thickness of the nail plate both in the entire study group and taking into account gender. In the dominant hand, the results were r = -0.341; p < 0.001; r = -0.417, p < 0.001; and r = 0.337; p = 0.001 (for the whole group, for women, and for men, respectively). In the non-dominant hand, the results were r = -0.465; p < 0.001; r = -0.493, p < 0.01; and r = -0.503; p < 0.01 (for the whole group, for women, and for men, respectively). There were statistically significant differences in the thickness of the nail plates of the corresponding types of fingers between female and male NUs. Statistically significant correlations were found between the type of a finger and the TOWL value in the whole group and taking into account gender (p < 0.05), except for the non-dominant hand in men. There were no statistically significant differences in the TOWL values of the corresponding types of fingers between male and female NUs (p > 0.05). There was no statistically significant correlation between the TOWL value and the nail plate thickness in any of the tested NUs, apart from the one statistically significant correlation in nd5 (r = 0.390, p = 0.021). Conclusions: To sum up, non-invasive methods, such as HF-USG and TOWL, enable assessment of the NU and are useful in examination of its structure and function. HF-USG shows characteristic elements of NUs that can be distinguished because of differences in their echogenicity. The thickness of the nail plate and TOWL depend on the type of finger, and show a relationship with gender.

CanDIG: Federated network across Canada for multi-omic and health data discovery and analysis.

We present the Canadian Distributed Infrastructure for Genomics (CanDIG) platform, which enables federated querying and analysis of human genomics and linked biomedical data. CanDIG leverages the standards and frameworks of the Global Alliance for Genomics and Health (GA4GH) and currently hosts data for five pan-Canadian projects. We describe CanDIG's key design decisions and features as a guide for other federated data systems.

Change of Specimen Temperature during the Monotonic Tensile Test and Correlation between the Yield Strength and Thermoelasto-Plastic Limit Stress on the Example of Aluminum Alloys.

This paper presents an attempt to generalize the description of the course of specimen temperature changes during the tensile test and to connect the value of the thermoelasto-plastic limit stress with the value of a clear (physical) or proof strength (offset yield strength) on the example of tests of the following aluminum alloy sheets used in Poland for airplane structures: 2024-T3 and D16 in three grades: D16ATV, D16CzATV, and D16UTV. A thermographic camera was used for specimen surface temperature measurement during the tensile test. The Portevine-Le Chatelier effect (the so-called PLC effect) was observed for tests of specimens cut from sheet plates, which was strongly reflected in the temperature fluctuations. The course of temperature change during tensile tests was divided into four characteristic stages related to the occurrence of a clear or offset yield strength. It was found that if there is a clear yield strength, the value of the thermoelasto-plastic limit stress was greater than this yield strength. If there was an offset yield strength, the value of the thermoelasto-plastic limit stress was lower than this yield strength. The differences in the aforementioned values of individual yield strengths did not exceed several percent. Thus, it can be concluded that the thermoelasto-plastic limit stress determined on the basis of the course of specimen temperature changes during the tensile test is well correlated with the value of the yield strength of the material.