[Cardiorespiratory and electrolytic changes in status asthmaticus after intravenous administration of magnesium sulfate]. / Magnézium-szulfát intravénás adása után bekövetkezö cardiorespiratoricus és elektrolit változások status asthmaticusban.

The authors studied cardiorespiratory effects of MgSO4 infusion in 30 randomized patients with status asthmaticus. They found, that after having the drug administered, values of VC, FEV1, FIV1, PaO2 and pH increased, the respiratory and heart rate, diastolic blood pressure reduced. Other ventilation, blood gas and ECG parameters were unchanged. Among the electrolytes, serum Ca2+ level has reduced, both plasma and intracellular Mg2+ concentrations increased. It is apparent from the results, that broncholytical ability of MgSO4 given in therapeutical dose i.v. does not reach the level of beta-stimulating agents. However, this completed with the cardioprotective, sedative effect as well as more advantageous ion-distribution, influences favourably the asthmatic dyspnoea.

[Bronchoalveolar lavage in the confirmation of pulmonary involvement in chronic lymphoid leukemia]. / Bronchoalveolaris mosás chronicus lymphoid leukaemia pulmonalis megjelenésének alátámasztására.

The authors made bronchoalveolar lavage (BAL) for explaining the origin of diffuse bilateral lung--infiltration in patients with chronic lymphoid leukaemia. On the base of lavage-fluid, the lung damage may be caused by leukaemic infiltration. The lesion has not changed by antibiotic therapy, but was radiologically cured after giving corticoids. The authors have not read about approaching chronic lymphoid leukaemic pulmonary infiltration by BAL. They call attention to the etiologic clarification of lung organs' complications in haematological aspects and outstanding role of BAL as a non-invasive method.

Molecular requirements of endotoxin (ET) actions: changes in the immune adjuvant, TNF liberating and toxic properties of endotoxin during alkaline hydrolysis.

The effect of alkaline pH and alkaline hydrolysis on the physico-chemical and biological properties of endotoxin (ET) isolated from Serratia marcescens ATCC 13477 by the Biovin procedure was studied. Major emphasis was put on the ion exchange column chromatography and immune adjuvant activity (ADA) of the alkali treated samples. To measure changes in some endotoxicity parameters, Limulus lysate clotting (LAL), chick embryo lethality, Shwartzman skin reactivity and in vitro TNF release were measured. The toxic properties of ET, with the unique exception of the Shwartzman skin reactivity, rapidly diminished during alkaline treatment. As immunogen CBre3, a recombinant HIV glycoprotein which spans the C terminus of gp 120 and the N terminus of gp 41, was used in CD-1 mice, alkali treated and immediately neutralized ET samples (zero time) were inactive as adjuvants, in some cases immunosuppression could be clearly seen. But if the alkaline hydrolysis was continued for 6 h, the ADA became higher than it had been for the starting ET sample. Further alkaline hydrolysis eliminated the ADA of the samples. Both NaOH and propylamine acted similarly on the ET preparation. Reaction kinetic studies of the NaOH detoxification indicated the cleavage of ester bound acyl groups with low binding energy. Chemical analyses of the samples revealed that changes occurred in the fatty acid composition, characterized by a loss of approximately half of the 3-OH myristic acid content.