RESUMO
The impact exerted by hydrogen peroxide on the virulent properties of anthrax pathogen spores was experimentally evaluated. Even a short-term exposure of them to a disinfect was shown to cause impairments of the functional nature in the spores' vital structures, e.g. suppression of multiplication. At the same time, the biological monitoring of disinfection efficiency does not always rule out the presence of viable pathogen spores in the disinfected objects.
Assuntos
Bacillus anthracis/efeitos dos fármacos , Desinfetantes/farmacologia , Peróxido de Hidrogênio/farmacologia , Animais , Antraz/prevenção & controle , Bacillus anthracis/patogenicidade , Humanos , Camundongos , Esporos Bacterianos/efeitos dos fármacos , Esporos Bacterianos/patogenicidade , Virulência/efeitos dos fármacosRESUMO
The authors analyzed the experience of disinfection experts related with the designing of new disinfection chemicals and of their composition variations. The key regularities were defined, which are important for the designing of effective disinfectants with preset properties capable of rapidly and safely inactivating a microbe contamination of different objects in the human habitat. A high antimicrobial activity and good outlooks are demonstrated for disinfectants made on the basis of hydrogen peroxide.
Assuntos
Desinfetantes/farmacologia , Peróxidos/farmacologia , Esporos/efeitos dos fármacos , Peróxido de Hidrogênio/farmacologia , Controle de Infecções , Esporos/patogenicidadeRESUMO
New nutrient media for cultivation of the tobramycin-producing organism were developed. As an additional source of nitrogen the media contain fermentative hydrolysate of the mycelial waste of manufacture of aminoglycoside antibiotics (tobramycin and apramycin). The use of the media provided a 20 to 50% decrease of consumption of soybean meal, an essential food raw material, and design of a low-waste technology for biosynthesis of tobramycin.
