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1.
Stress Health ; 39(4): 894-901, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-36719632

RESUMO

The Nightmare Disorder Index Questionnaire (NDI) was developed to measure the impact of nightmares. The purpose of this study was to investigate the psychometric properties of NDI among Chinese adolescents. This study investigated the validity and internal consistency of the Nightmare Disorder Index Chinese (NDI-CV) among 6014 Chinese adolescents who completed the NDI-CV, Nightmare Distress Questionnaire-Chinese Version (NDQ-CV), Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Chinese Adolescent Daytime Sleepiness Scale (CADSS), Generalized Anxiety Disorder-7 Questionnaire (GAD-7), and Patient Health Questionnaire-9 (PHQ-9). In addition, we investigated the test-retest reliability of the NDI-CV among 423 adolescents who completed a retest of the NDI-CV after a 2-week interval. Finally, NDI-CV demonstrated good psychometric properties in a sample of Chinese adolescents (Cronbach's α coefficient of 0.876), and the 95% confidence interval for the 2-week retest correlation coefficient was 0.675-0.977 (p < 0.001).


Assuntos
Sonhos , Psicometria , Adolescente , Humanos , Reprodutibilidade dos Testes , Inquéritos e Questionários , População do Leste Asiático
2.
Huan Jing Ke Xue ; 39(7): 3240-3246, 2018 Jul 08.
Artigo em Chinês | MEDLINE | ID: mdl-29962148

RESUMO

In this study, a novel combined system for simultaneous recovery of bioelectricity and water from wastewater was developed by integrating anaerobic acidification and a forward osmosis (FO) membrane with a microbial fuel cell (AAFO-MFC). Conductivity was thought to be an important factor affecting the performance of the AAFO-MFC system. Thus, effects of conductivity on the performance of AAFO-MFC system in treating synthetic wastewater were investigated. The results indicated that a higher conductivity increased the bioelectricity production, owing to a reduction in the internal resistance. However, it resulted in a rapid decrease of FO water flux and a shorter operating time because of a severer membrane fouling. The conductivity had no impact on the water quality of the effluents. The total organic carbon (TOC) and total phosphorus (TP) concentrations in the FO permeate were less than 4 and 0.5 mg·L-1, respectively, at all conductivity levels. However, the rejection of the FO membrane for NH4+-N was lower at all conductivity levels. The optimal comprehensive performance of this system was obtained when the conductivity was maintained at 7-8 mS·cm-1. In this case, the AAFO-MFC system achieved continuous and relatively stable power generation, and the water flux of FO membrane was relatively stable during a long-term operation of approximately 29 days.


Assuntos
Fontes de Energia Bioelétrica , Osmose , Membranas Artificiais , Águas Residuárias , Purificação da Água
3.
Cell Mol Neurobiol ; 35(4): 555-62, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25563203

RESUMO

Synaptic damage is the key factor of cognitive impairment. The purpose of this study was to understand the effect of soybean isoflavone (SIF) on synaptic damage induced by ß-amyloid peptide 1-42 (Aß1-42) in rats. Adult male Wistar rats were randomly divided into control, Aß1-42, SIF, and SIF + Aß1-42 (SIF pretreatment) groups according to body weight. SIF was treated orally by gavage in SIF and SIF + Aß1-42 groups. After 14 days pretreatment with SIF or vehicle, Aß1-42 was injected into the lateral cerebral ventricle of rats in Aß1-42 and SIF + Aß1-42 groups using miniosmotic pump. The level of Aß1-42 and the expression of N-methyl-D-aspartic-acid receptor (NMDAR) were observed by immunohistochemistry. Reverse transcriptase polymerase chain reaction was used to detect the mRNA levels of NMDAR, calmodulin (CaM), calcium/CaM-dependent protein kinase II (CaMKII), cAMP-response element binding protein (CREB), and brain-derived neurotrophic factor (BDNF). The results showed that Aß1-42 down-regulated mRNA and protein expression of the NR1 and NR2B subunits of NMDAR, SIF pretreatment could reverse these changes. The mRNA expression of CaM, CaMKII, CREB, and BDNF were down-regulated by Aß1-42, but they were all regulated by SIF pretreatment. These results suggest that SIF pretreatment could antagonize the neuron damage in rats induced by Aß1-42, and its mechanism might be associated with the NMDA receptor and CaM/CaMKII/CREB/BDNF signaling pathway, which are the synaptic plasticity-related molecules.


Assuntos
Peptídeos beta-Amiloides/farmacologia , Glycine max/química , Isoflavonas/farmacologia , Fragmentos de Peptídeos/toxicidade , Receptores de N-Metil-D-Aspartato/metabolismo , Transdução de Sinais/efeitos dos fármacos , Peptídeos beta-Amiloides/toxicidade , Animais , Encéfalo/efeitos dos fármacos , Encéfalo/metabolismo , Fator Neurotrófico Derivado do Encéfalo/genética , Fator Neurotrófico Derivado do Encéfalo/metabolismo , Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/genética , Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/metabolismo , Calmodulina/genética , Calmodulina/metabolismo , Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/genética , Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo , Masculino , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , Ratos Wistar , Receptores de N-Metil-D-Aspartato/genética
4.
Synapse ; 67(12): 856-64, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23766238

RESUMO

This research aims to investigate whether soybean isoflavone (SIF) could alleviate the learning and memory deficit induced by ß-amyloid peptides 1-42 (Aß 1-42) by protecting the synapses of rats. Adult male Wistar rats were randomly allocated to the following groups: (1) control group; (2) Aß 1-42 group; (3) SIF group; (4) SIF + Aß 1-42 group (SIF pretreatment group) according to body weight. The 80 mg/kg/day of SIF was administered orally by gavage to the rats in SIF and SIF+Aß 1-42 groups. Aß 1-42 was injected into the lateral cerebral ventricle of rats in Aß 1-42 and SIF+Aß 1-42 groups. The ability of learning and memory, ultramicrostructure of hippocampal synapses, and expression of synaptic related proteins were investigated. The Morris water maze results showed the escape latency and total distance were decreased in the rats of SIF pretreatment group compared to the rats in Aß1-42 group. Furthermore, SIF pretreatment could alleviate the synaptic structural damage and antagonize the down-regulation expressions of below proteins induced by Aß1-42: (1) mRNA and protein of the synaptophysin and postsynaptic density protein 95 (PSD-95); (2) protein of calmodulin (CaM), Ca(2+) /calmodulin-dependent protein kinase II (CaMK II), and cAMP response element binding protein (CREB); (3) phosphorylation levels of CaMK II and CREB (pCAMK II, pCREB). These results suggested that SIF pretreatment could ameliorate the impairment of learning and memory ability in rats induced by Aß 1-42, and its mechanism might be associated with the protection of synaptic plasticity by improving the synaptic structure and regulating the synaptic related proteins.


Assuntos
Peptídeos beta-Amiloides/toxicidade , Glycine max/química , Isoflavonas/farmacologia , Aprendizagem em Labirinto/efeitos dos fármacos , Memória/efeitos dos fármacos , Fragmentos de Peptídeos/toxicidade , Extratos Vegetais/farmacologia , Sinapses/efeitos dos fármacos , Animais , Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/genética , Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/metabolismo , Calmodulina/genética , Calmodulina/metabolismo , Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/genética , Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo , Proteína 4 Homóloga a Disks-Large , Hipocampo/citologia , Hipocampo/efeitos dos fármacos , Hipocampo/metabolismo , Hipocampo/fisiologia , Peptídeos e Proteínas de Sinalização Intracelular/genética , Peptídeos e Proteínas de Sinalização Intracelular/metabolismo , Isoflavonas/uso terapêutico , Masculino , Proteínas de Membrana/genética , Proteínas de Membrana/metabolismo , Transtornos da Memória/induzido quimicamente , Transtornos da Memória/tratamento farmacológico , Fosforilação , Fitoterapia , Extratos Vegetais/uso terapêutico , Ratos , Ratos Wistar , Tempo de Reação , Sinapses/metabolismo , Sinapses/fisiologia , Sinapses/ultraestrutura , Transcrição Gênica
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