RESUMO
Both Sjögren's syndrome (SS) and non-Sjögren's syndrome (NSS) can present with the sicca symptoms of dry eyes and a dry mouth but they are distinct pathological entities that require diagnostic discrimination. This study included 82 sicca syndrome patients and examined the ability of sialoscintigraphy and antibodies against the autoantigens alpha-fodrin, Ro and La to discriminate between SS and NSS. A total of 30.8% of SS patients compared with 58.8% of NSS patients were alpha-fodrin positive. The prevalence of Ro positivity was 69.4% for SS patients compared with 0% for NSS patients. The prevalence of La positivity was 52.4% for SS compared with 0% for NSS patients. Sialoscintigraphy showed that more NSS patients had grade III salivary gland impairment compared with SS patients (64.7% versus 19.4%). These data suggest that using sialoscintigraphy in combination with measuring the levels of serum alpha-fodrin, Ro and La might be useful for SS and NSS discrimination.
Assuntos
Autoanticorpos/imunologia , Cintilografia/métodos , Glândulas Salivares/patologia , Síndrome de Sjogren/diagnóstico , Xeroftalmia/diagnóstico , Autoantígenos/análise , Autoantígenos/sangue , Autoantígenos/imunologia , Biomarcadores/sangue , Proteínas de Transporte/imunologia , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Proteínas dos Microfilamentos/imunologia , Pessoa de Meia-Idade , Ribonucleoproteínas/análise , Ribonucleoproteínas/imunologia , Glândulas Salivares/diagnóstico por imagem , Síndrome de Sjogren/imunologia , Xeroftalmia/imunologia , Antígeno SS-BRESUMO
Anarthria and bilateral central faciolinguopharyngeomasticatory paralysis with automatic voluntary dissociation are the clinical hallmarks of Foix-Chavany-Marie syndrome (FCMS), the cortico-subcortial type of suprabulbar palsy. We present a 64-year-old man who was admitted due to acute onset of speechlessness for days. Neurological examinations demonstrated typical features of FCMS. Cranial MRI showed a right opercular lesion and several lacunar infarcts in bilateral hemispheres. Hexamethylpropylenamine oxime (HMPAO) brain SPECT revealed hypoperfusion in bilateral opercular regions and notably on the right side. In review of previous reports, the most common etiology of FCMS is stroke in the region of either operculum. Our case may be a good example of FCMS after multiple cerebrovascular insults over bilateral opercular cortico-subcortical areas as demonstrated in MRI and SPECT studies.
Assuntos
Paralisia Pseudobulbar/diagnóstico , Diagnóstico Diferencial , Humanos , Masculino , Pessoa de Meia-Idade , Paralisia Pseudobulbar/complicações , Paralisia Pseudobulbar/fisiopatologiaRESUMO
Technetium-99m HIDA hepatic lobar distribution and retention ratios were developed to evaluate patients with intrahepatic lithiasis. The data of 57 cases were analyzed. Results reveal a highly significant difference in these ratios between the patients and normal individuals. They are simple, objective, and easily obtainable. Thus, the determination of these ratios may replace [99mTc]HIDA sequential scintiphotography, which is qualitative and time consuming, for screening intrahepatic lithiasis.
Assuntos
Cálculos/diagnóstico por imagem , Iminoácidos , Hepatopatias/diagnóstico por imagem , Tecnécio , Humanos , Fígado/diagnóstico por imagem , Cintilografia , Lidofenina Tecnécio Tc 99m , Fatores de TempoRESUMO
Sequential scintiphotography with Tc-99m pyridoxylideneglutamate was used to evaluate patients under strong suspicion of intrahepatic stones. The scintiphotos of 19 cases were analyzed. Results indicate that the sequential study reveals an excretion pattern pertinent to the diagnosis of intrahepatic stone. This simple and innocuous approach would be a useful screening technique for this disease.
