RESUMO
An outbreak of 7 cases of group C meningococcal disease occurred during the last week of July and the first week of August 2001 in the southwestern part of The Netherlands. Characterization of the 7 patients' isolates by various typing methods showed that the isolates were identical, except for the expression of PorA. Isolates from 5 patients were PorA deficient. These results show that transmission of PorA-deficient meningococci occurs and that PorA-deficient meningococci can cause invasive disease. PorA-based meningococcal vaccines may provide limited protection.
Assuntos
Surtos de Doenças , Infecções Meningocócicas/epidemiologia , Infecções Meningocócicas/microbiologia , Neisseria meningitidis Sorogrupo C/classificação , Porinas/metabolismo , Adolescente , Adulto , Técnicas de Tipagem Bacteriana , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Dados de Sequência Molecular , Neisseria meningitidis Sorogrupo C/genética , Neisseria meningitidis Sorogrupo C/isolamento & purificação , Países Baixos/epidemiologia , Porinas/genética , Análise de Sequência de DNA , SorotipagemRESUMO
In this study 51 women, who had stated that they suffered from premenstrual syndrome (PMS), answered a Dutch adaptation of the Moos' Menstrual Distress Questionnaire (MDQ) every other day for at least two consecutive menstrual cycles. Results showed a clear increase in symptomatology starting about seven days before menstruation and reaching a maximum at the second day of the following cycle. Diagnostic criteria to categorize individual women showed, over 2 years, a substantial decrease of the number of women with PMS in one or both of two menstrual cycles.