RESUMO
Serological diagnosis of cystic echinococcosis (CE) is usually made by detecting specific antibodies in serum samples. However, collection of blood samples is difficult and may be hazardous and unsafe. Thus, it is important to assess alternative simple methods of sampling body fluids that give similar results. Saliva and urine have been suggested as possible alternatives to detect specific antibodies for the diagnosis of various diseases. To the best of our knowledge, there has been no previously published study regarding the detection of CE-specific immunoglobulin (Ig) G subclass antibodies (IgG1-4) in urine. Therefore, the present study was designed to assess the value of hydatid-specific antibodies of IgG, IgM, IgE and IgG subclass in urine and serum samples for the diagnosis of CE. Serum and urine samples of 41 surgically confirmed patients of CE, 40 patients with other diseases and 16 healthy subjects were included in the study. CE-specific total IgG, IgE and IgG4 in sera and total IgG, IgG4 and IgG1 in the urine of CE patients were the most important specific antibodies for the diagnosis of CE. However, total IgG usually persists for an extended period and has a very high cross-reactivity. The diagnostic sensitivity of hydatid-specific IgM in serum and urine samples was very low and therefore cannot be used as a diagnostic marker. There was no significant difference between IgG1 and IgG4 in serum and urine and both showed the best correlation for the diagnosis of CE. These considerations suggest that detection of antibodies in urine could provide a new approach in the diagnosis of CE.
Assuntos
Anticorpos Anti-Helmínticos/sangue , Anticorpos Anti-Helmínticos/urina , Equinococose/diagnóstico , Echinococcus/isolamento & purificação , Testes Sorológicos/métodos , Adulto , Animais , Equinococose/sangue , Equinococose/parasitologia , Equinococose/urina , Echinococcus/imunologia , Feminino , Humanos , Índia , Masculino , Pessoa de Meia-IdadeRESUMO
Mayer Rokintansky-Kuster-Hauser syndrome is characterized by the congenital absence of the vagina with a variety of Müllerian duct anomalies. Because of normal sexual development, the syndrome usually remains undetected until primary amenorrhea and/or difficulty in attempting sexual intercourse result in the diagnosis. MRKHS frequently is associated with anomalies of the urinary tract (unilateral agenesis, or ectopia of one or both kidneys, horse-shoe kidney), cervico-thoracic region (asymmetric, fused or wedged vertebrae, scoliosis and Klippel-Feil anomaly), congenital cardiac defects, hearing defects, and digital anomalies of varying severity. Congenital heart diseases in the form of atrial septal defect, Holt-Oram Syndrome with or without aorticopulmonary window, pulmonary stenosis etc in association with MRKHS have been described in the literature. We present a case of MRKHS with unilateral agenesis of the kidney and atrial septal defect with partial anomalous pulmonary venous connection. This combination of anomalies has not been reported in the literature so far. The various presentations and the pathogenesis of the condition are discussed.
Assuntos
Comunicação Interatrial/complicações , Rim/anormalidades , Veias Pulmonares/anormalidades , Transtornos 46, XX do Desenvolvimento Sexual/complicações , Anormalidades Múltiplas , Adolescente , Anormalidades Congênitas , Feminino , Humanos , Ductos Paramesonéfricos/anormalidades , Somitos/anormalidades , Coluna Vertebral/anormalidades , Síndrome , Útero/anormalidades , Vagina/anormalidadesRESUMO
BACKGROUND: Combined liver and lung hydatid cysts are rare, but pose a challenge in terms of accessibility. The objective of the study was to find an alternative approach to conventional two-stage posterolateral thoracotomy and laparotomy or single-stage extensive thoracolaparotomy. METHODS: Twenty-five patients with right lung and liver hydatid disease underwent single-stage anterior minithoracotomy and phrenotomy. Primary diagnostic tools were chest radiography, ultrasonography and serology. The preferred mode of management of hydatid cysts was enucleation and partial or total capitonnage. RESULTS: Thirty-six (13.5 per cent) of 267 patients had concurrent hepatic and pulmonary hydatid cysts. Among the 25 patients who had anterior minithoracotomy and phrenotomy the male : female ratio was 2 : 1. Mean operating time was 75 min. Morbidity was negligible and postoperative recovery was prompt. All of the patients survived. The mean hospital stay was 5.2 days. Overall observations were encouraging. CONCLUSION: This minimally invasive approach is associated with less morbidity and better cosmesis than conventional procedures. It represents an excellent alternative to other procedures in selected patients.
Assuntos
Equinococose Hepática/cirurgia , Equinococose Pulmonar/cirurgia , Laparotomia/métodos , Nervo Frênico/cirurgia , Toracostomia/métodos , Adolescente , Adulto , Perda Sanguínea Cirúrgica , Criança , Pré-Escolar , Equinococose Hepática/complicações , Equinococose Pulmonar/complicações , Feminino , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X/métodosRESUMO
BACKGROUND: Unrepaired aortic coarctation is known to have a detrimental effect on survival. The benefit of coarctation repair on systolic hypertension in adults has been questioned. This retrospective study was conducted to evaluate the impact of repair of aortic coarctation on systolic hypertension in adults. METHODS: Repair of aortic coarctation was performed in 84 patients aged 16-54 (mean 29) years. All patients were hypertensive before surgical intervention (mean systolic blood pressure 162 mmHg; mean diastolic blood pressure 93 mmHg). All patients underwent echocardiography and/or cardiac catheterization. The peak mean systolic gradient across the coarctation was 60 mmHg. The patients were followed after coarctation repair for between 1 and 12 (mean 5.2) years. RESULTS: There was significant regression of hypertension (P < 0.001) in all patients. Thirty-five patients (42 per cent) did not need any antihypertensive medication 3 months after surgery. The prevalence of hypertension at the last follow-up (after mean 5.2 years) was 31 per cent. CONCLUSION: Surgical repair of coarctation of the aorta in adults leads to regression of systolic hypertension and a decreased requirement for antihypertensive medication.
Assuntos
Coartação Aórtica/cirurgia , Hipertensão/cirurgia , Adolescente , Adulto , Distribuição por Idade , Coartação Aórtica/fisiopatologia , Pressão Sanguínea , Feminino , Seguimentos , Humanos , Hipertensão/fisiopatologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do TratamentoRESUMO
Bochdalek diaphragmatic hernia is one of the most important surgically correctable causes of respiratory distress in the newborn. Delayed presentation in adult life is uncommon. We present a case of a 46-year-old, multigravida Kashmiri woman, who was misdiagnosed earlier and treated for pulmonary tuberculosis. Diagnosis was established pre-operatively by plain chest radiograph and barium meal. A dorso-lateral defect was located on left side of diaphragm which was corrected by using a prolene mesh.