RESUMO
Electrohydrodynamic method was used to produce both single-drug and dual-drug loaded nanocomposites. Zein was blended with ethyl cellulose, and the mixture was electrospun into nanofibers. Polyethylene oxide was electroprayed into nanoparticles and deposited on the nanofibrous matrix. Indomethacin and tetracycline hydrochloride were loaded in the nanocomposites as model drugs. The suitable electrospraying conditions were chosen based on the result of scanning electron microscopy. Fourier transform infrared spectra indicated that components were merely physically combined. Differential scanning calorimetry and X-ray diffraction confirmed amorphous states of the drugs in the nanocomposites. The nanocomposites displayed good wettability, water-stability and improved modulus. In vitro dissolution tests revealed a desirable drug release profile, which abided by Fickian diffusion.
Assuntos
Liberação Controlada de Fármacos , Eletroquímica/métodos , Hidrodinâmica , Nanocompostos/química , Varredura Diferencial de Calorimetria , Indometacina , Nanocompostos/ultraestrutura , Polietilenoglicóis/química , Espectroscopia de Infravermelho com Transformada de Fourier , Estresse Mecânico , Água/química , Molhabilidade , Difração de Raios X , Zeína/químicaRESUMO
A simple and cost-effective way to prepare water-stable zein-based nanofibers for potential drug delivery was presented in this article. Corn protein zein was co-electrospun with hydrophobic ethyl cellulose. Indomethacin, as a model drug, was incorporated in situ into the composite nanofibers. Scanning electron microscopy and element mapping revealed the morphologies of drug-loaded nanofibers and drug distribution, respectively. Fourier transform infrared spectra confirmed the physical blending among the components. Differential scanning calorimetry and X-ray diffraction demonstrated the physical state of drug and polymers in the nanofiber matrix. The composite nanofibers showed a sustained diffusion-controlled release according to the results of in vitro dissolution tests.
Assuntos
Celulose/análogos & derivados , Portadores de Fármacos/química , Indometacina/química , Nanofibras/química , Zeína/química , Varredura Diferencial de Calorimetria , Celulose/química , Liberação Controlada de Fármacos , Estabilidade de Medicamentos , Indometacina/metabolismo , Microscopia Eletrônica de Varredura , Espectroscopia de Infravermelho com Transformada de Fourier , Água/química , Molhabilidade , Difração de Raios XRESUMO
Indium nitrate/polyvinyl pyrrolidone (In(NO3)3/PVP) composite nanofibers were synthesized via electrospinning, and then hollow structure indium oxide (In2O3) nanofibers were obtained through calcination with PVP as template material. In situ polymerization was used to prepare indium oxide/polyaniline (In2O3/PANI) composite nanofibers with different mass ratios of In2O3 to aniline. The structure and morphology of In(NO3)3/PVP, In2O3/PANI composite nanofibers and pure PANI were investigated by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM) and current-voltage (I-V) measurements. The gas sensing properties of these materials towards NH3 vapor (100 to 1000 ppm) were measured at room temperature. The results revealed that the gas sensing abilities of In2O3/PANI composite nanofibers were better than pure PANI. In addition, the mass ratio of In2O3 to aniline and the p-n heterostructure between In2O3 and PANI influences the sensing performance of the In2O3/PANI composite nanofibers. In this paper, In2O3/PANI composite nanofibers with a mass ratio of 1:2 exhibited the highest response values, excellent selectivity, good repeatability and reversibility.