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1.
Zhonghua Yi Shi Za Zhi ; 41(4): 227-30, 2011 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-22169490

RESUMO

Sponsored by the Public Health Committee of Chinese Medical Association and published by the Chinese Medical Association, the Chinese Health Monthly started publication in Shanghai in 1939 and the chairman of the Public Health Committee of Chinese Medical Association, HUANG Zifang, was appointed as the chief editor. Clear in its column setting, comprehensive in contents and strict with scrutiny of the advertisements, this journal had excellent texts, pictures and English abstracts. WANG Jimin and YU Xinen served as chief editors and issuers after the death of HUANG Zifang and made contributions to the development of the journal. Due to economic distress and wars, there have been great difficulties in publication of the Chinese Health Monthly. The publication was finally stopped in 1951 for adjustment of academic societies and journals.

2.
Biol Pharm Bull ; 30(6): 1123-9, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17541165

RESUMO

The objectives of this study were to investigate the antihyperglycemic effect of Cephalotaxus sinensis leaves and to identify the active components. The antihyperglycemic effect of various fractions (FA, FB, FC, FD) of the 80% ethanol extract of the leaves was evaluated in streptozotocin (STZ)-induced diabetic rats. Among the tested fractions, FC was the most active. FC (0.48 g/kg) given orally for 10 d reduced significantly (p<0.001) the blood glucose of STZ-induced diabetic rats. The food and water intakes of FC (0.48 g/kg)-treated diabetic rats were reduced significantly (p<0.001) when compared to the 0.5% carboxymethyl cellulose (CMC)-treated diabetic rats. The activity-guided fractionation of the ethanol extract of C. sinensis leaves furnished three flavonoid compounds, apigenin-5-O-[alpha-L-rhamnopyranosyl-(1-->4)-6-O-beta-D-acetylglucopyranoside] (1), apigenin (2), and apigenin-5-O-[alpha-L-rhamnopyranosyl-(1-->4)-6-O-beta-D-glucopyranoside] (3). The elevation of GLUT-4 protein level in membrane preparations from mice adipocytes was detected by Western blot analysis after adipocytes were pre-incubated with FC (0.1, 1, 10 mg/ml), apigenin (0.1, 2 mg/ml) and apigenin-5-O-[alpha-L-rhamnopyranosyl-(1-->4)-6-O-beta-D-acetylglucopyranoside] (0.1, 2 mg/ml), respectively. Phytochemical investigation and HPLC-DAD analysis of FC indicated that the flavonoids were the major constituents in this fraction. These results suggest that the fraction from C. sinensis leaves is a promising drug for the treatment of diabetes, and that the flavonoids from this plant are the active constituents.


Assuntos
Cephalotaxus/anatomia & histologia , Flavonoides/química , Transportador de Glucose Tipo 4/metabolismo , Hipoglicemiantes/farmacologia , Folhas de Planta/química , Adipócitos/citologia , Animais , Glicemia/análise , Western Blotting , Carboximetilcelulose Sódica/farmacologia , Membrana Celular/química , Cromatografia Líquida de Alta Pressão , Diabetes Mellitus Experimental , Relação Dose-Resposta a Droga , Ingestão de Líquidos/efeitos dos fármacos , Avaliação Pré-Clínica de Medicamentos , Ingestão de Alimentos/efeitos dos fármacos , Flavonoides/farmacologia , Glipizida/farmacologia , Insulina/farmacologia , Masculino , Metilaminas/farmacologia , Camundongos , Estrutura Molecular , Extratos Vegetais/farmacologia , Extratos Vegetais/uso terapêutico , Ratos , Ratos Wistar
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