The Impact of Urinary Catheterization on the Antibiotic Susceptibility of ESBL-Producing Enterobacterales: A Challenging Duo.

INTRODUCTION: Antimicrobial resistance (AMR) is currently a growing concern among healthcare providers, underscoring the importance of describing the regional susceptibility profile for common microorganisms that are associated with urinary tract infections (UTIs). This knowledge serves as the foundation for proper empirical therapeutic recommendations tailored to local susceptibility patterns. RESULTS: We found a high prevalence of ESBL-producing strains (36.9%), with Escherichia coli and Klebsiella spp. being the most prevalent isolated bacteria. Among the catheterized patients, Klebsiella spp. emerged as the primary etiology, with a significant correlation between catheterization and Proteus spp. (p = 0.02) and Providencia stuartii (p < 0.0001). We observed significant correlations between urinary catheterization and older age (68.9 ± 13.7 years vs. 64.2 ± 18.1 years in non-catheterized patients, p = 0.026) and with the presence of an isolate with extensive drug resistance (p < 0.0001) or even pandrug resistance (p < 0.0001). Susceptibility rates significantly decreased for almost all the tested antibiotics during the study period. Notably, susceptibility was markedly lower among catheterized patients, with the most pronounced differences observed for carbapenems (59.6% versus 83.4%, p < 0.0001) and aminoglycosides (37.1% versus 46.9%, p = 0.0001). MATERIALS AND METHODS: We conducted a retrospective study analyzing the susceptibility profiles of 724 extended-spectrum beta-lactamases (ESBL)-producing Enterobacterales isolated from urine cultures. Our focus was on highlighting susceptibility profiles among isolates associated with urinary catheterization and assessing the shifts in the susceptibility rates over time. CONCLUSIONS: The constant rise in AMR rates among Enterobacterales presents significant challenges in treating severe infections, particularly among urinary catheterized patients. This trend leaves clinicians with limited or no effective treatment options. Consequently, the development and implementation of personalized treatment protocols are imperative to ensure efficient empirical therapies.

Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia: A Literature Review.

Hospital-acquired pneumonia (HAP) and its subtype, ventilator-associated pneumonia (VAP), remain two significant causes of morbidity and mortality worldwide, despite the better understanding of pathophysiological mechanisms, etiology, risk factors, preventive methods (bundle of care principles) and supportive care. Prior detection of the risk factors combined with a clear clinical judgement based on clinical scores and dosage of different inflammatory biomarkers (procalcitonin, soluble triggering receptor expressed on myelloid cells type 1, C-reactive protein, mid-regional pro-adrenomedullin, mid-regional pro-atrial natriuretic peptide) represent the cornerstones of a well-established management plan by improving patient's outcome. This review article provides an overview of the newly approved terminology considering nosocomial pneumonia, as well as the risk factors, biomarkers, diagnostic methods and new treatment options that can guide the management of this spectrum of infections.

Liver Damage Associated with SARS-CoV-2 Infection-Myth or Reality?

(1) Introduction: While the primary impairment in COVID-19 is pulmonary, the ubiquitous distribution of angiotensin-converting enzyme 2 (ACE2) demonstrates the possible presence of systemic disease with involvement of the heart, kidneys, liver and other organs. (2) Methods: We retrospectively studied the observation sheets of patients diagnosed with SARS-CoV-2 infection hospitalized in the "Sf. Parascheva" Clinical Hospital of Infectious Diseases from Iasi for a period of 3 months. The aim of the study was to identify the frequency of liver injury due to SARS-CoV-2 infection among patients and its impact on the course of the disease. (3) Results: Out of the total number of hospitalized cases (1552), 207 (13.34%) were the subjects of our analysis. The severe form of SARS-CoV-2 infection predominated (108 cases; 52.17%) and in terms of liver damage, in all cases increased transaminase levels predominated and were determined to be secondary to the viral infection. We divided the lot into two groups, A (23 cases; 23.19%) and B (159 cases; 76.81%), depending on the time of onset of liver dysfunction, either at the time of hospitalization or during hospitalization. The evolution of liver dysfunction was predominant in most cases, with an average time of onset at 12.4 days of hospitalization. Death occurred in 50 cases. (4) Conclusions: This study revealed that high AST and ALT at hospital admission was associated with a high mortality risk in COVID-19 patients. Therefore, abnormal liver test results can be a significant prognostic indicator of outcomes in COVID-19 patients.

Characteristics and Trends of COVID-19 Infection in a Tertiary Hospital in Romania: A Retrospective Study.

(1) Background: The outbreak of the COVID-19 pandemic represented a real challenge for all of humanity. Characterized by a complex spectrum of signs and symptoms, by various severity degrees, the disease spread rapidly around the world. After more than two and half years since the beginning of COVID-19 pandemic, in the context of a paradoxical, enigmatic, and relentless COVID-19, the objective of the current study was to evaluate the characteristics and evolution of patients with SARS-CoV-2 infection, hospitalized in "St. Parascheva" Clinical Hospital of Infectious Diseases (Iasi, Romania). (2) Methods: This is a retrospective study that used the medical database recorded between July and November 2021 in order to highlight the characteristics of SARS-CoV-2 infection in patients from the northeastern region of Romania. (3) Results: We enrolled in the study a total of 1732 SARS-CoV-2 infected patients, mean age 67 ± 3.4 years, the female gender predominating (987 cases; 56.98%) as well as patients from the urban environment (982 patients; 56.69%). Moderate form of the disease predominated (814 cases; 47%), pulmonary imaging changes were found in 1042 (60.16%) cases, and 1242 (71.71%) patients had at least one underlying disease. After a median length of hospitalization of 9.5 days, 1359 (78.46%) patients were discharged cured, 48 (2.77%) were transferred to other services by decompensating the associated pathologies, 302 (17.43%) patients needed extensive support in the intensive care unit and there were 325 (18.76%) deaths. (4) Conclusions: The epidemiological characteristics of SARS-CoV-2 infection recorded in our study were mostly the same as characteristics of COVID-19 from all over the world.

Effectiveness of 8- and 12-Week Treatment with Ombitasvir/ Paritaprevir/Ritonavir and Dasabuvir in Treatment-Naïve HCV Patients in a Real-Life Setting in Romania: the AMETHYST Study.

BACKGROUND AND AIMS: The 12-week regimen of ombitasvir/paritaprevir/ritonavir and dasabuvir (OPrD) has shown high efficacy and tolerability in clinical trials for the treatment of chronic hepatitis C virus (HCV). The shorter 8-week regimen has been recently incorporated into clinical guidelines and on-label indications, but real-world evidence on its use is limited. Given this knowledge gap, the AMETHYST study aimed to evaluate the effectiveness of the 8- and 12-week regimens of OPrD in treatment-naive patients with HCV with mild to moderate liver fibrosis in Romanian clinical practice. METHODS: This was a secondary data collection study analyzing data from a 1-year Patient Support Program in HCV in Romania. Patients received OPrD treatment for 8 or 12 weeks. The effectiveness endpoint was sustained virologic response 12 weeks post-treatment (SVR12). RESULTS: A total of 1,835 treatment-naive patients with HCV with mild or moderate fibrosis were included in the study. Of these, 426 and 1,375 completed the 8-week and 12-week regimens, respectively. SVR12 was 98.1% in the 8-week treatment group and 98.7% in the 12-week treatment group. CONCLUSION: The study provides real-world evidence that 8-week and 12-week treatment regimens of OPrD are highly effective in treatment-naive patients with HCV with mild to moderate liver fibrosis.

Enterically transmitted hepatitis in the third millennium in northeastern Romania.

While the incidence of hepatitis A virus (HAV) infections has decreased in the last few years, the incidence of hepatitis E virus (HEV) is increasing in developed countries. Both infections remain a worldwide reality, strongly related to socio-economic conditions. We retrospectively analyzed the medical files of patients with viral hepatitis hospitalized in the Infectious Disease Hospital Iasi, Romania between 2018 and 2019. The serological confirmed cases of HAV and HEV infections were included in the analysis; included in our analysis were 269 HAV-infected patients. The most affected were males (53.9% cases) aged between 8 and 15 years (53.6% cases). Severe infections were recorded at admission in 2.24% cases and evolution was favorable under supportive and symptomatic treatment. Only three adult males, with no recent history of travel, were confirmed with HEV infection. Even though we have identified a small number of cases, recent studies performed in our region found a seroprevalence of 32.5% in the general population, possibly related to zoonotic transmission. While outbreaks of HAV infection are still noted in our region, a lack of hospitalized HEV-infected patients suggest that most cases are asymptomatic or underdiagnosed. HEV infection remains an underreported disease, possibly due to misdiagnosis, subclinical or dual hepatitis infection, but with a significant risk in vulnerable categories, such as pregnant women or immunosuppressed patients.

Apolipoproteins A and B and PCSK9: Nontraditional Cardiovascular Risk Factors in Chronic Kidney Disease and in End-Stage Renal Disease.

PURPOSE: Nontraditional cardiovascular risk factors as apolipoprotein A (ApoA), apolipoprotein B (ApoB), and the proprotein convertase subtilisin/kexin type 9 (PCSK9) increase the prevalence of cardiovascular mortality in chronic kidney disease (CKD) or in end-stage renal disease (ESRD) through quantitative alterations. This review is aimed at establishing the biomarker (ApoA, ApoB, and PCSK9) level variations in uremic patients, to identify the studies showing the association between these biomarkers and the development of cardiovascular events and to depict the therapeutic options to reduce cardiovascular risk in CKD and ESRD patients. METHODS: We searched the electronic database of PubMed, Scopus, EBSCO, and Cochrane CENTRAL for studies evaluating apolipoproteins and PCSK9 in CKD and ESRD. Randomized controlled trials, observational studies (including case-control, prospective or retrospective cohort), and reviews/meta-analysis were included if reference was made to those keys and cardiovascular outcomes in CKD/ESRD. RESULTS: 18 studies met inclusion criteria. Serum ApoA-I has been significantly associated with the development of new cardiovascular event and with cardiovascular mortality in ESRD patients. ApoA-IV level was independently associated with maximum carotid intima-media thickness (cIMT) and was a predictor for sudden cardiac death. The ApoB/ApoA-I ratio represents a strong predictor for coronary artery calcifications, cardiovascular mortality, and myocardial infarction in CKD/ESRD. Plasma levels of PCSK9 were not associated with cardiovascular events in CKD patients. CONCLUSIONS: Although the "dyslipidemic status" in CKD/ESRD is not clearly depicted, due to different research findings, ApoA-I, ApoA-IV, and ApoB/ApoA-I ratio could be predictors of cardiovascular risk. Serum PCSK9 levels were not associated with the cardiovascular events in patients with CKD/ESRD. Probably in the future, the treatment of dyslipidemia in CKD/ESRD will be aimed at discovering new effective therapies on the action of these biomarkers.

Morphopathological stigmata in acne fulminans.

Acne fulminans is the most aggressive and destructive form of acne vulgaris, being also known as acne maligna. The onset is acute and systemic involvement is always present. Most commonly, acne fulminans (AF) occurs in male adolescents as a brutal complication of a preexisting mild or moderate acne. The etiology of AF remains incompletely elucidated. The skin lesions are polymorphic, the symptoms and clinical signs vary, and thus the diagnosis is not easy. In making a certain diagnosis of AF, histopathology has a decisive role. In this respect, we will present some of the most suggestive aspects of histopathology, immunohistochemistry and electron microscopy in a 16-year-old patient clinically diagnosed with AF. This patient presented on admission nodular inflammatory and ulcerative necrotic lesions on the face and chest, extremely, accompanied by significant myalgias and arthralgias.

NEW PERSPECTIVES IN THE DIAGNOSIS AND THE TREATMENT OF CHILDHOOD FEBRILE EXANTHEMAS.

A child with a febrile exanthema is a complex medical problem involving diagnostic challenges, epidemiological threats and a great concern for the parents and any physician, should be prepared to deal with it. Many of the classical ones (measles, rubella, chickenpox) have now a decreased incidence due to a high vaccine coverage, which makes even harder for the physician to establish an early diagnosis. To the untrained eye most of them are difficult to differentiate. Their prompt recognition is necessary in order to manage them adequately and to prevent spreading of the disease.

Adverse reactions of biological therapy for psoriasis.

AIM: To detect in patients with psoriasis the adverse effects during TNF-a inhibitor therapy. MATERIAL AND METHODS: Fifty-seven patients with psoriasis, aged between 12 and 75 years were analyzed. They were treated with different TNF-α antagonists, the maximum treatment duration being 59 months. All patients were followed monthly after the initiation of therapy by clinical checkup, then every 3 months during the first 6 months of treatment by laboratory screening, and then every 6 month. Chest x-ray and tuberculin intradermal skin test were performed annually or as needed. All symptoms reported by patients were recorded, the treating doctor deciding the need for additional investigations or specialist consult. RESULTS: Of the total of 57 patients with psoriasis on biological therapy, 9 patients developed diseases requiring temporary or permanent discontinuation of therapy. The recorded adverse reactions were: infectious (pulmonary tuberculosis, pulmonary empyema), oncologic (rectal cancer, renal cancer), dermatologic (vesiculobullous erythema multiforme major, nodular hypodermtis, secondary erythroderma, and hives) disorders. CONCLUSIONS: Despite its adverse reactions, biological therapy is safe and is a necessary tool in the treatment of moderate and severe forms of psoriasis unresponsive to other treatments.

ETIOLOGY AND RESISTANCE PROFILE OF ISOLATED STRAINS FROM SEVERE SYSTEMIC INFECTIONS IN PATIENTS WITH IMMUNODEPRESSION--EXPERIENCE OF THE IASI INFECTIOUS DISEASES HOSPITAL 2011-2014.

UNLABELLED: Microbial resistance is an increasingly serious threat to global public health and it is linked to patient's age, immune status, and also antibiotic overuse or misuse and repeated hospitalizations. The high incidence of infections caused by multidrug-resistant bacteria requires rethinking the first-line therapeutic schemes. AIM: Retrospective study of the etiologic and antibiotic resistance profile of the bacterial strains isolated from immunocompromised hosts diagnosed with severe systemic infections, aimed at gaining a better understanding of the potential infectious sources and optimizing the antibiotic therapy. MATERIAL AND METHODS: 178 cases of severe sepsis associated with immunosuppression (caused by diabetes, malignancies, liver cirrhosis, chronic alcohol abuse, kidney failure) were admitted to the "St. Parascheva" Infectious Diseases Hospital Iasi in the interval January 2011- December 2014. RESULTS: The mean age of the study patients was 61 years, most patients being female (53%) and living in urban areas (51%). The causal agents were: Escherichia coli (20.2%), Klebsiella pneumoniae (16.8%), Pseudomonas aeruginosa (14.6%), Methicillin-Sensitive Staphylococcus aureus (MSSA) (11.2%), Enterococcus spp. (10.1%), Methicillin-Resistant Staphylococcus aureus (MRSA) (8.9%), Proteus spp.(5%), Acinetobacter baumanii (5%), Streptococcus pyogenes (1.6%), Staphylococcus epidermidis (1.1%) and Citrobacter (0.5%). As to the resistance profile the following were found: 100% susceptibility of MRSA and Enterococcus species to vancomycin, as well as for the Enterococcus species; 27% of E. coli strains were resistant to beta-lactams and 20% of Klebsiella pneumoniae to carbapenems. Antibiotic therapy associated two or three drugs with an immediate result and a favorable outcome in 84.2% of the cases. CONCLUSIONS: The etiological agents implicated in the occurrence of severe sepsis in patients with acquired immunosuppression were Gram-positive bacteria (GPB) as well as Gram-negative bacteria (GNB) with moderate resistance to usual antibiotics. The infections caused by GNB were predominant in immunocompromised patients, but also in those with associated urinary and respiratory tract infections and chronic indwelling urinary catheters. In our severe sepsis patients Gram positive bacteria caused mainly skin and joint infections.

Epidemiological and laboratory features of chronic hepatitis B cases in the interval 2010-2013.

UNLABELLED: HBV virus infection is an important public health problem because of its huge transmission potential, and severe evolution to cirrhosis or liver cancer. AIM: Analysis of the epidemiological and laboratory features of chronic hepatitis B virus infection. MATERIAL AND METHODS: The patients with chronic hepatitis B admitted to the "Sf. Parascheva" University Hospital for Infectious Diseases in the interval: January 1st, 2010 - December 31st were analyzed. RESULTS: Patients age was 18 to 66 years with a prevalence of middle-aged males. Most patients came from urban areas. Alanine aminotransferase (ALAT) levels were elevated, without significant differences between HBeAg-positive and HBeAg-negative patients, the elevated ALAT levels being associated with the increased prevalence of fibrosis. HBeAg-positive patients had viral loads above the threshold of 2,000/l in 34 cases (89.5%), and below 2,000 IU/l in only 10.5% of cases, and the majority (88%) of HBeAg-negative patients presented high viral load levels. The prevalence of stage F2-F4 liver fibrosis was 63.4% in the HBeAg-negative patients with viremia > 25,000 IU/l compared to 55.2% in the HBeAg-positive patients. The correlation between the level of viral load and fibrosis shows that there are significant differences between viremia and the status of HBeAg-positive or negative patients. Increased viral load was correlated with increasing prevalence of fibrosis, significant in HBeAg-negative patients, and the increasing fibrosis prevalence was correlated with low viral load. CONCLUSIONS: The correlation between viral load and fibrosis shows that there are significant differences between viral load and the status of HBAg-positive or negative patients.

Correlation between asthma and Toxocara canis infection.

UNLABELLED: The aim of the current study was to examine the relationship between asthma and toxocariasis. MATERIAL AND METHODS: We have studied 76 patients with asthma and 88 controls (without asthma) aged 5-16 years. An ELISA test based on the detection of anti-Toxocara canis (E/S antigen) serum immunoglobulin G (IgG) and E (IgE) was done in both groups. Ordinary allergens and E/S antigen of T. canis infections were used to evaluate cutaneous reactivity. RESULTS: Seroprevalence in asthma patients was 68.42% and in the controls 13.63%. This difference was significant. The percentage of asthmatic patients with two anti-Toxocara antibodies was 26.31%, and of 4.54% in controls. All asthma patients with anti-Toxocara IgE had cutaneous reactivity to Ag E/S. CONCLUSIONS: Asthma patients with anti-Toxocara IgE and IgG may have toxocariasis.

Tuberculous meningitis--clinical and epidemiological considerations (a retrospective study 2008-2011).

UNLABELLED: Tuberculous meningitis represents one of the most severe forms of tuberculosis and is often a difficult diagnostic and therapeutic problem. The objective of this study is to analyze the cases of tuberculous meningitis in our region. MATERIAL AND METHODS: We retrospectively analyzed 76 observation sheets of patients aged 4 months to 84 years, diagnosed with tuberculous meningitis, admitted to Infectious Diseases Hospital Iasi during 2008 to 2011. RESULTS: Tuberculous meningitis has affected mostly males (65.7%). Only a small proportion of patients (23.68%) had tuberculosis in their personal history. 26.2% were diagnosed also with other localization of tuberculosis (mostly pulmonary). Fever was identified in only 43.4% of cases; 40% of patients had an altered conscience at admission. The outcome was favorable in all cases. CONCLUSIONS: Tuberculous meningitis predominantly affects males, almost equally affects patients with other focuses of TB and those with a history of tuberculosis disease.

[Sensitization to ascaris lumbricoides and asthma severity in children]. / Influenta ascaridiozei asupra severitatii astmului bronsic la copil.

UNLABELLED: There is little information concerning asthma severity and sensitization to Ascaris lumbricoides in pediatric patients. MATERIAL AND METHODS: The relationship between sensitization to Ascaris lumbricoides and asthma severity in 219 patients with a high prevalence of parasitic exposure (IgE antibodies) was studied by using linear, multivariate and logistic regression. RESULTS: Sensitization to Ascaris lumbricoides was associated with positive skin tests for aeroallergens, increased total serum IgE, increased eosinophils, reductions in FEV1 and FEV1/FVC ratio, increased airway Methacholine, bronchodilator responsiveness, and hospitalizations for asthma in the past year. CONCLUSIONS: Sensitization to Ascaris lumbricoides is associated with increased severity of asthma among Romanian children. This association is mediated by a high degree of atopy among the asthma children sensitized to Ascaris lumbricoides and belonging to a population with a low prevalence of helminthiasis.

Synthesis and antituberculosis activity of some new pyridazine derivatives. Part II.

A series of eighteen novel compounds with pyridazine moiety were synthesized and their in vitro antituberculosis activities have been evaluated. A fast, general, and facile method for preparation of pyridazine derivatives in moderate to excellent yields is presented. Three compounds were found to be moderate active against Mycobacterium tuberculosis. Correlation of structure-biological activity has been done.

Considerations concerning design and mechanism of action of a new class of anticancer dual DNA intercalators.

Cancer is one of the most serious and merciless health problems of the mankind, about seven million people dying of cancer every year. Two of the most important and promising targets in cancer chemotherapy include DNA alkylating agents and DNA intercalators. The emphasis of this work was to design, synthetize and formulate a mechanism of action for a new class of dual DNA intercalators. The dual DNA intercalators have three main parts: an alkylating unit (represented by two halo-alkyl-ester chains), an intercalator unit (five- or six-membered ring nitrogen heterocycle) and an acetophenone skeleton linker. As mechanism of action, we consider that these compounds act as dual DNA intercalators, the alkylating unit realizing a covalent bonding via DNA protein "cross-linking effect" while nitrogen heterocycles will realize noncovalent bonding via DNA intercalation with purine and pyrimidine bases from DNA and the amino acids from topoisomerases enzymes. Our hypothesis was confirmed by in vitro anticancer tests against HeLa cell lines, where the newly obtained compounds demonstrated a very good activity.

[Atopic diseases and intestinal helminth infections]. / Afectiunile atopice si infectia intestinala cu helminti.

UNLABELLED: The purpose of the current study was to examine the relationship between past and current intestinal helminth infections, and asthma, allergic rhino-conjunctivitis, and atopic dermatitis. MATERIAL AND METHOD: The study was performed on 84 patients aged 2-18 years with a mean of 9.31 +/- 3.75 years. Helminth infection was determined by stool examinations and questionnaire. Asthma was diagnosed by spirometry, atopic dermatitis and allergic rhino-conjunctivitis by skin prick testing. RESULTS: Stool examinations revealed infection with A. lumbricoides in 5.95% of cases and E. vermicularis in 4.76% of cases. 8 patients had positive tests for at least a helminth. The most frequent respiratory symptoms were caught, wheezing and dispneea. Spirometry showed anormal results in 4.76% of patients and skin tests were positive in 20.24% of cases. 11 patients were diagnosed with allergic rhinoconjunctivitis and 5 with atopic dermatitis. A history of infection with E. vermicularis was associated with increased risk of atopic dermatitis (OR 1.86), asthma (OR 2.11), and allergic rhinoconjunctivitis (OR 1.34), and a positive stool examination for A. lumbricoides was negatively associated with asthma (OR 2.60). CONCLUSIONS: Current A. lumbricoides infection protects against asthma while past infection with E. vermicularis are risk factors for allergic rhinoconjunctivitis, asthma and atopic dermatitis. Interactions depend on the type of helminth and time of infestation.

[Toxocariasis respiratory manifestations in cases hospitalized in the Paediatric Diseases Clinic of Iasi, between 2005-2008]. / Manifestari respiratorii la copiii cu toxocaroza spitalizati in perioada 2005-2008.

UNLABELLED: The authors present the results of retrospective epidemiological, clinical and laboratory diagnosis on toxocariasis cases hospitalized in the Pediatric Diseases Clinic of Iasi, between January 2005-June 2008. MATERIAL AND METHOD: The study included a number of 228 children. RESULTS: Respiratory manifestations were present in 184 children: 105 boys (46.05%) and 79 girls (34.64%), with a slight advance of the rural environment (44.29%). The age distribution highlighted a predominance of 1-5 years of age (65.76%). Respiratory manifestations were fever, coughing, wheezing, asthma, infections of respiratory pathways, pneumonia. The distribution of toxocariasis in children patients in Moldavia, Romania, highlighted a predominance in Iasi. The children with respiratory manifestations had hypereosinophilia associated with hyperleucocytosis. All the patients were serologically confirmed with toxocariasis. The children responded well to treatment with albendazole.

[Cutaneous manifestations on toxocariasis cases hospitalized in the Paediatric Diseases Clinic of Iasi, between 2005-2008]. / Manifestari cutanate la copiii cu toxocaroza spitalizati in perioada 2005-2008.

UNLABELLED: The authors present the results of retroprospective epidemiological, clinical and laboratory diagnosis on toxocariasis cases hospitalized in the Paediatric Diseases Clinic of Iasi, between January 2005- June 2008. MATERIAL AND METHOD: The study included a number of 228 children. RESULTS: Cutaneous manifestations were present in 65 children: 30 boys (46.15%) and 34 girls (52.30%), with a slight advance of the urban environment (53.84%). The age distribution highlighted a predominance of 1-6 age (66.15%). Cutaneous manifestations were pruritus, urticaria, atopic dermatitis, prurigo. The distribution of toxocariasis in children patients in Moldavia, Romania, highlighted a predominance in Iasi. The laboratory diagnosis of the children with cutaneous manifestations: hypereosinophilia was present on 87.69% of the children associated with hyperleucocytosis. All the patients were serologicaly confirmed with toxocariasis. The children responded well to treatment with albendazole.