[The enhanced bioavailability of mebendazole in echinococcosis patients when used with Essentiale]. / Povyshenie biodostupnosti mebendazola u bol'nykh ékhinokokozami pri ego primenenii s éssentsiale.

Mebendasole is better absorbed in the gastrointestinal tract if administered together with essential to patients with hydatid disease. Thirty-four patients with alveolar and hydatid echinococcosis were administered mebendasol in a daily dose of 50 mg/kg in 4 doses and essentiale in a daily dose of 600-1000 mg in 4 doses. A total of 86 therapeutic courses, 30 days each, were carried out. The treatment was sufficiently well tolerated. Mebendasole levels in the course of therapy surpassed the minimal effective ones in 2/3 of the patients, that is, they were significantly higher than in administration of mebendasole alone.

[Interleukin-1 production in patients with subacute and chronic opisthorchiasis]. / Produktsiia interleikina-1 u bol'nykh podostrym i khronicheskim opistorkhozom.

Interleukin-1 (IL-1) production by peripheral blood lymphocytes was studied in 3 patients with the subacute and in 28 patients with the chronic stage of the disease. Monocyte culture was obtained by the H. R. Recalde method, IL-1 activity was evaluated by the S. B. Mizel modification of the classic LAF-ASSAY. In the subacute stage of the disease IL-1 activity was 3.3 fold lower that in healthy controls and lower than in the total group of patients with chronic opisthorchiasis (Kact. 0.64 +/- 0.09, 2.12 +/- 0.17, 1.83 +/- 0.11, respectively, p < 0.01, p < 0.01). In those with the syndrome of chronic gastroduodenitis IL-1 production was lower than in patients with the syndrome of cholepathy (Kact. 1.55 +/- 0.18 and 2.03 +/- 0.16, p < 0.01). Immediately after praziquantel therapy IL-1 production fell from Kact. 1.82 +/- 0.13 to 1.18 +/- 0.06 (p < 0.01), but 5-6 months later the production of the cytokine normalized in convalescents.

[The computer processing of data from experimental research on malaria. 2. The quantitative characteristics of parasitemia dynamics]. / Komp'iuternaia obrabotka dannykh éksperimental'nykh issledovanii po maliarii. Soobshchenie 2. Kolichestvennaia kharakteristika dinamiki parazitemii.

Models of simple and modified logistic function have been used for the quantitative characteristics of malaria infection development. The approach could be successfully used, which was demonstrated on experimental infection dynamics in rodents during parasitemia assessment both in absolute and logarithmic scales. Regression analysis of experimental data and choice of an optimal form of logistic equation are performed with the help of specially elaborated software. The calculated values of logistic parameters may be used for characterization of malaria parasite strains and isolates, their virulence and resistance, as well as the degree of their resistance to drugs.

[The computer processing of experimental research data on malaria. 1. The primary processing of the dynamic indices of malarial infection]. / Komp'iuternaia obrabotka dannykh éksperimental'nykh issledovanii po maliarii. Soobshchenie 1. Pervichnaia obrabotka pokazatelei dinamiki maliariinoi infektsii.

Universal computer software for primary statistical and graphic analysis of data on malaria dynamics in patients and in the experiment has been suggested. The analysis of the results of investigations on rodent malaria model in based on graded parasitemia assessment according to Moshkovskii [correction of Mashkovsky].

[A computer estimation of Plasmodium falciparum sensitivity to antimalarial compounds based on in vitro test data]. / Komp'iuternyi raschet chuvstvitel'nosti Plasmodium falciparum k antimaliarriinym soedineniiam po dannym testa in vitro.

A modified computer programme has been suggested for the assessment of falciparum malaria agent sensitivity to malariacidal agents. Regression analysis of the results of the in vitro tests is performed using a logistic function.

[Interleukin-1 production in patients with unilocular echinococcosis]. / Produktsiia interleikina-1 u bol'nykh odnokamernym ékhinokokkozom.

The production of interleukin-1 (IL-1) by peripheral blood monocytes was estimated by the H. R. Recalde method (1984) in 45 patients with echinococcosis and 10 virtually healthy controls. In echinococcosis patients interleukin-1 turned to be significantly lower (p less than 0.05) than in the controls (Kact 1.2 +/- 0.1 and 2.2 +/- 0.1 respectively). In patients with a malignant course of the disease (mostly in those with disseminated lung damages) Kact of Il-1 was 0.93 +/- 0.1. In patients who underwent surgical interventions 1.5-6 years before Kact of Il-1 reached 1.43 +/- 0.1 but was still lower (p less than 0.05) than in the controls. The lowest production of IL-1 was identified in patients with lung disseminated lesions and bone damages (Kact 0.9 +/- 0.1 and 0.79 +/- 0.1, respectively).

[Clinical trial of the possibility of increasing the bioavailability of mebendazole using sunflower oil in echinococcosis]. / Klinicheskoe ispytanie vozmozhnosti povysheniia biodostupnosti mebendazola s pomoshch'iu podsolnechnogo masla pri ékhinokokkozakh.

Increasing mebendazole bioavailability is one of the most important problems to be solved in echinococcosis chemotherapy. The method of mebendazole administration with sunflower oil, elaborated by the authors, serves to this purpose: drug concentration exceeding the minimal effective one was attained in 86% patients treated with mebendazole and sunflower oil and only in 40% patients treated with the drug alone.