Conjugated Microporous Polymers-Based Catalytic Membranes with Hierarchical Channels for High-Throughput Removal of Micropollutants.

Engineering a catalytic membrane capable of efficiently removing emerging organic microcontaminants under ultrahigh flux conditions is of significance for water purification. Herein, drawing inspiration from the functional attributes of lymphatic vessels involved in immunosurveillance and fluid transport with minimal energy consumption, a novel hierarchical porous catalytic membrane is engineered. This membrane, based on an innovative nitrogen-rich conjugated microporous polymer (polytripheneamine, PTPA), is synthesized using an electrospinning coupled in situ polymerization approach. The resulting bioinspired membrane with hierarchical channels comprises a thin layer (≈1.7 µm) of crosslinked PTPA nanoparticles covering the interconnected electrospun nanofibers. This unique design creates an intrinsic microporous angstrom-confined system capable of activating peroxymonosulfate (PMS) to generate 98.7% singlet oxygen (1O2), enabling durable and highly efficient degradation of microcontaminants. Additionally, the presence of a thin layer of mesoporous structure between PTPA nanoparticles and macroporous channels within the interwoven nanofibers enhances mass transfer efficiency and facilitates high flux rates. Notably, the prepared hierarchical porous organic catalytic membrane demonstrates enduring high-efficiency degradation performance with a superior permeance (>95% and >2500 L m-2 h-1 bar-1) sustained over 100 h. This work introduces an innovative pathway for the design of high-performance catalytic membranes for the removal of emerging organic microcontaminants.

Gut microbiota modulation: a narrative review on a novel strategy for prevention and alleviation of ovarian aging.

The global rise in life expectancy corresponds with a delay in childbearing age among women. Ovaries, seen as the chronometers of female physiological aging, demonstrate features of sped up aging, evidenced by the steady decline in both the quality and quantity of ovarian follicles from birth. The multifaceted pathogenesis of ovarian aging has kindled intensive research interest from the biomedical and pharmaceutical sectors. Novel studies underscore the integral roles of gut microbiota in follicular development, lipid metabolism, and hormonal regulation, forging a nexus with ovarian aging. In this review, we outline the role of gut microbiota in ovarian function (follicular development, oocyte maturation, and ovulation), compile and present gut microbiota alterations associated with age-related ovarian aging. We also discuss potential strategies for alleviating ovarian aging from the perspective of gut microbiota, such as fecal microbiota transplantation and probiotics.

Nanofibrous Porous Organic Polymers and Their Derivatives: From Synthesis to Applications.

Engineering porous organic polymers (POPs) into 1D morphology holds significant promise for diverse applications due to their exceptional processability and increased surface contact for enhanced interactions with guest molecules. This article reviews the latest developments in nanofibrous POPs and their derivatives, encompassing porous organic polymer nanofibers, their composites, and POPs-derived carbon nanofibers. The review delves into the design and fabrication strategies, elucidates the formation mechanisms, explores their functional attributes, and highlights promising applications. The first section systematically outlines two primary fabrication approaches of nanofibrous POPs, i.e., direct bulk synthesis and electrospinning technology. Both routes are discussed and compared in terms of template utilization and post-treatments. Next, performance of nanofibrous POPs and their derivatives are reviewed for applications including water treatment, water/oil separation, gas adsorption, energy storage, heterogeneous catalysis, microwave absorption, and biomedical systems. Finally, highlighting existent challenges and offering future prospects of nanofibrous POPs and their derivatives are concluded.

Large-Scale Proteome Profiling Identifies Biomarkers Associated with Suspected Neurosyphilis Diagnosis.

Neurosyphilis (NS) is a central nervous system (CNS) infection caused by Treponema pallidum (T. pallidum). NS can occur at any stage of syphilis and manifests as a broad spectrum of clinical symptoms. Often referred to as "the great imitator," NS can be easily overlooked or misdiagnosed due to the absence of standard diagnostic tests, potentially leading to severe and irreversible organ dysfunction. In this study, proteomic and machine learning model techniques are used to characterize 223 cerebrospinal fluid (CSF) samples to identify diagnostic markers of NS and provide insights into the underlying mechanisms of the associated inflammatory responses. Three biomarkers (SEMA7A, SERPINA3, and ITIH4) are validated as contributors to NS diagnosis through multicenter verification of an additional 115 CSF samples. We anticipate that the identified biomarkers will become effective tools for assisting in diagnosis of NS. Our insights into NS pathogenesis in brain tissue may inform therapeutic strategies and drug discoveries for NS patients.

Carbon Nanotube Template-Assisted Synthesis of Conjugated Microporous Polytriphenylamine with High Porosity for Efficient Supercapacitive Energy Storage.

Engineering of conjugated microporous polymers (CMPs) with high porosity, redox activity, and electronic conductivity is of significant importance for their practical applications in electrochemical energy storage. Aminated-multiwall carbon nanotubes (NH2 -MWNT) are utilized to modulate the porosity and electronic conductivity of polytriphenylamine (PTPA), which is synthesized via Buchwald-Hartwig coupling reaction of tri(4-bromophenyl)amine and phenylenediamine as constitutional units in a one-step in situ polymerization process. Compared to PTPA, the specific surface area of core-shell PTPA@MWNTs has been greatly improved from 32 to 484 m2  g-1 . The PTPA@MWNTs exhibites an improved specific capacitance, with the highest value 410 F g-1 in 0.5 M H2 SO4 at a current of 10 A g-1 achieve for PTPA@MWNT-4 due to the hierarchical meso-micro pores, high redox-activity and electronic conductivity. Symmetric supercapacitor assemble by PTPA@MWNT-4 has a capacitance of 216 F g-1 of total electrode materials and retains 71% of initial capacitance after 6000 cycles. This study gives new insights into the role of CNT templates in the adjustment of molecular structure, porosity, and electronic property of CMPs for the high-performance electrochemical energy storage.

Clinical value of combined predictors of RET%, γ-GT, LDH in the ABO neonatal hemolytic disease.

Objective: The purpose of this study is to examine the prognostic significance of the amalgamated indicators, reticulocyte percentage (RET%), lactate dehydrogenase (LDH), and γ-Glutamyltransferase (γ-GT), in neonatal ABO hemolytic disease. Methods: A total of 137 hospitalized children with pathological jaundice were included. Based on their medical conditions, they were categorized into two groups, hemolytic (67 cases) and non-hemolytic (70 cases). Pearson linear correlation and binary logistic multivariate analysis were used to analyze LDH, γ-GT, RET% and hemolysis. Furthermore, the predictive value of the combined predictors of RET%, LDH, and γ-GT on ABO neonatal hemolytic disease was evaluated using the ROC curve analysis. Results: The laboratory indexes of the two groups were subject to analysis using binary logistic regression to identify suspicious influencing factors. The study revealed that RET%, LDH, and γ-GT were independent risk factors for hemolysis. Pearson linear correlation analysis indicated a positive correlation between LDH and γ-GT with RET% (r = 0.529, P < 0.01; r = 0.526, P = <0.01, respectively). Furthermore, the predictive value of each combined predictor was obtained using the ROC curve, and it was observed that combined predictor L (RET% + LDH + γ-GT)>L1 (RET% + LDH)>L2 (RET% + γ-GT). Conclusion: Combined predictor L (RET% + LDH + γ-GT)demonstrate its optimal diagnostic efficacy, offering a novel approach towards diagnosing early-onset ABO hemolytic disease of the newborn.

Effects of yak and Tibetan sheep grazing on soil arthropods community in an alpine meadow on the Qinghai-Tibet Plateau, China.

We investigated the responses of community structure of soil arthropods to yak and Tibetan sheep grazing based on a manipulated grazing experiment at the alpine meadow livestock Adaptive Management Platform, which locates in Haiyan County, Qinghai Province. The results showed that the obtained soil arthropods belonged to 26 families, 8 orders, and 4 classes, with Acaroidae and Oribatida as the dominant groups. Yak and Tibetan sheep grazing decreased the abundance but increased Shannon index, Margalef index and Pielou index of soil arthropods. Yak grazing significantly increased the quantity of the predatory soil arthropod groups. Yak and Tibetan sheep gra-zing significantly increased the quantity of the detritivore soil arthropod groups, but did not affect the quantity of the omnivorous and phytophagous soil arthropod groups. Yak and Tibetan sheep grazing significantly reduced the abundance of soil mites. Soil bulk density, available potassium, and available nitrogen were the main abiotic factors affecting soil arthropods community composition.

Multidimensional climatic niche conservatism and invasion risk of Phenacoccus solenopsis.

The cotton mealybug Phenacoccus solenopsis, a globally invasive insect, is listed as a national quarantine pest in agriculture and forestry, which seriously threatens biological safety of China. Niche conservatism is a key assumption of species distribution model. An evaluation of the applicability of using ecological niche models to assess the invasion risk of cotton mealybug, and further optimizing model complexity, are of both theoretical and practical significance. Based on 706 occurrence records and key bioclimatic variables, we used n-dimensional hypervolume niche analysis method to quantify the climatic niche hypervolumes of this pest in both native and invasive sites, and further tested the niche conservatism hypothesis. MaxEnt model parameters were optimized to predict the invasion risk of the mealybug under current and future climate scenarios in China. The results showed that four climatic variables (annual mean temperature, mean temperature of wettest quarter, mean temperature of warmest quarter, and precipitation of driest quarter) were the key climate factors affecting the distribution of cotton mealybug. Compared with native climatic niche (hypervolume volume, HV=40.43), the niche hypervolume of cotton mealybug in the invasive areas was significantly reduced (HV=6.04). Niche contraction (the net differences between the amount of space enclosed by each hypervolume was 0.84) explained 98.8% of niche differentiation, whereas niche shift (the replacement of space between hypervolumes was 0.01) contributed less than 2%. The direction of climatic niche contraction of the pest in different invasive areas was not exactly consistent. The default parameters of MaxEnt model were unreliable (ΔAICc=14.27), and the optimal parameter combination was obtained as follows: feature combination was linear-quadratic-hinge-product and regularization multiplier was 0.5. The most suitable habitats of cotton mealybug were concentrated in the south of Huaihe River-Qinling Mountains line, and the north-central provinces contained a large area of low suitable habitat. The increase of suitable habitat was not significant at the end of 21 century (SSP1-2.6: 1.7%, SSP5-8.5: 0.7%). The multidimensional climatic niche of P. solenopsis was highly conservative. The species distribution model was suitable for analyzing its invasion risk. The northward spread was obvious, and climate change had less impact on the pest.

Children's oral health and oral health care use during the first 2 years of the COVID-19 pandemic.

BACKGROUND: The COVID-19 pandemic has been associated with declines in children's oral health and oral health care use in 2020. The authors examined the pandemic effects on these outcomes into 2021. METHODS: This cross-sectional study used data from the National Survey of Children's Health from 2017 through 2021. The authors compared parent's or caregiver's perceptions of the child's oral health and reported dental problems and dental visits across years, adjusting for child and household covariates and state of residence. The authors evaluated potential heterogeneity across demographic and socioeconomic subgroups. RESULTS: In 2021, parents and caregivers were still more likely to perceive children's oral health as poor (odds ratio [OR], 1.90; 95% CI, 1.28 to 2.82) and less likely to report very good or excellent oral health (OR, 0.83; 95% CI, 0.76 to 0.92) than in 2019, similar to differences between 2020 and 2019. Dental visits were also less likely in 2021 than 2019 (OR, 0.74; 95% CI, 0.66 to 0.83). These differences between 2021 and 2019 were not explained by prepandemic trends and were observed across a range of demographic and socioeconomic subgroups. CONCLUSIONS: Children's oral health as perceived by parents and caregivers and oral health care use were still worse in 2021 than before the pandemic both overall and across demographic and socioeconomic subgroups. PRACTICAL IMPLICATIONS: The persistent adverse effects of the COVID-19 pandemic on children's oral health as perceived by parents and caregivers and shown through dental visits highlight the need to improve oral health care access and use and to evaluate the long-term effects of the pandemic on children's oral health.

An Oral Microbial Biomarker for Early Detection of Recurrence of Oral Squamous Cell Carcinoma.

Changes in the oral microbiome are associated with oral squamous cell carcinoma (OSCC). Oral microbe-derived signatures have been utilized as markers of OSCC. However, the structure of the oral microbiome during OSCC recurrence and biomarkers for the prediction of OSCC recurrence remains unknown. To identify OSCC recurrence-associated microbial biomarkers for the prediction of OSCC recurrence, we performed 16S rRNA amplicon sequencing on 54 oral swab samples from OSCC patients. Differences in bacterial compositions were observed in patients with vs without recurrence. We found that Granulicatella, Peptostreptococcus, Campylobacter, Porphyromonas, Oribacterium, Actinomyces, Corynebacterium, Capnocytophaga, and Dialister were enriched in OSCC recurrence. Functional analysis of the oral microbiome showed altered functions associated with OSCC recurrence compared with nonrecurrence. A random forest prediction model was constructed with five microbial signatures including Leptotrichia trevisanii, Capnocytophaga sputigena, Capnocytophaga, Cardiobacterium, and Olsenella to discriminate OSCC recurrence from original OSCC (accuracy = 0.963). Moreover, we validated the prediction model in another independent cohort (46 OSCC patients), achieving an accuracy of 0.761. We compared the accuracy of the prediction of OSCC recurrence between the five microbial signatures and two clinicopathological parameters, including resection margin and lymph node counts. The results predicted by the model with five microbial signatures showed a higher accuracy than those based on the clinical outcomes from the two clinicopathological parameters. This study demonstrated the validity of using recurrence-related microbial biomarkers, a noninvasive and effective method for the prediction of OSCC recurrence. Our findings may contribute to the prognosis and treatment of OSCC recurrence.

Analysis of Automated Clinical Depression Diagnosis in a Chinese Corpus.

Depression clinical interview corpora are essential for advancing automated depression diagnosis. While previous studies have used written speech material in controlled settings, these materials do not accurately represent spontaneous conversational speech. Additionally, self-reported measures of depression are subject to bias, making the data unreliable for training models for real-world scenarios. This study introduces a new corpus of depression clinical interviews collected directly from a psychiatric hospital, containing 113 recordings with 52 healthy and 61 depressive patients. The subjects were examined using the Montgomery-Asberg Depression Rating Scale (MADRS) in Chinese. Their final diagnosis was based on medical evaluations through a clinical interview conducted by a psychiatry specialist. All interviews were audio-recorded and transcribed verbatim, and annotated by experienced physicians. This dataset is a valuable resource for automated depression detection research and is expected to advance the field of psychology. Baseline models for detecting and predicting depression presence and level were built, and descriptive statistics of audio and text features were calculated. The decision-making process of the model was also investigated and illustrated. To the best of our knowledge, this is the first study to collect a depression clinical interview corpus in Chinese and train machine learning models to diagnose depression patients.

Changes in Children's Health Care Access and Utilization in the United States in the First 2 Years of the COVID-19 Pandemic.

OBJECTIVE: To compare children's access to and utilization of health care services in the United States during the first 2 years of the pandemic to prepandemic levels. METHODS: This cross-sectional study used data from the 2017 to 2021 National Survey of Children's Health. Access to care was measured by having a usual place for sick and preventive care, having a personal doctor or nurse, and unmet care needs. Utilization measures included preventive, mental health, specialist, and emergency department (ED) visits, and hospital admissions in the past 12months. Outcomes were reported by parents or other caregivers. Multivariate logistic regressions were employed adjusting for sociodemographic factors and state of residence. The study sample included 163,353 children aged 0 to 17years. RESULTS: Compared to 2019, there were declines in the probability of having a usual place for sick care in 2020 (-1.5 percentage-points) and a usual place for preventive care in 2021 (-2.1 percentage-points), and greater probability of unmet care needs in 2020 (+1.2 percentage-points) and 2021 (+0.8 percentage-points). The probability of having any preventive, specialist, and ED visits and hospitalizations remained lower in 2021 than 2019 (-7.5, 2.2, 5.4 and 0.9 percentage-points, respectively). These differences were not explained by prepandemic trends and were observed across a range of sociodemographic subgroups. CONCLUSIONS: Children's health care access and utilization declined noticeably over the first 2years of the pandemic. Evaluating these outcomes in subsequent years and addressing barriers to care continue to be critical to reduce unmet needs.

Competitive proton-trapping strategy enhanced anti-freezing organohydrogel fibers for high-strain-sensitivity wearable sensors.

Stretchable organohydrogel fibers are attracting considerable interest for next-generation flexible and wearable soft strain sensors due to their excellent stability in harsh environments. However, due to the uniformly distributed ions and reduced number of carriers in the whole material, the sensitivity of organohydrogel fibers under subzero temperature is not desirable, which significantly hinders their practical application. Herein, a newly competitive proton-trapping strategy was designed to obtain anti-freezing organohydrogel fibers for high-performance wearable strain sensors via a simple freezing-thawing process, in which tetraaniline (TANI), serving as the proton trapper, and representing the shortest repeated structural unit of polyaniline (PANI), was physically crosslinked with polyvinyl alcohol (PVA) (PTOH). The as-prepared PTOH fiber exhibited an outstanding sensing performance at -40 °C due to the unevenly distributed ion carriers and the highly breakable proton-migration pathways, with a high gauge factor of 24.6 at a strain of 200-300%. Moreover, the existence of hydrogen bonds between the TANI and PVA chains endowed PTOH with a high tensile strength (1.96 MPa) and toughness (8.0 MJ m-3). Accordingly, strain sensors made from PTOH fibers and knitted textiles could monitor human motions rapidly and sensitively, demonstrating their potential as wearable anti-freezing anisotropic strain sensors.

Quinoa Ameliorates Hepatic Steatosis, Oxidative Stress, Inflammation and Regulates the Gut Microbiota in Nonalcoholic Fatty Liver Disease Rats.

A long-term high-fat diet causes hepatic steatosis, which further leads to oxidative stress and inflammation. In this study, we firstly investigated the regulation effects of different amounts of quinoa on hepatic steatosis, oxidative stress, and inflammation of rats fed a high-fat diet, then the gut microbiota was dynamically determined. Sprague-Dawley (SD, male) rats were randomized into four groups: normal controls (NC, fed standard chow), model groups (HF, fed a high-fat diet), low quinoa intake (HF + LQ), and high quinoa intake (HF + HQ) groups, which were supplemented with 9% and 27% quinoa in the high-fat feed (equivalent to 100 g/day and 300 g/day human intake, respectively). The results showed that quinoa intake significantly inhibited the hepatomegaly and splenomegaly, ameliorated hepatic steatosis pathologically; effectively rescued the decrease in the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) and the increase in malondialdehyde (MDA). The levels of tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), transforming growth factor-ß (TGF-ß), and leptin in rats of two quinoa groups were close to those of the NC group. Besides, high quinoa intake significantly increased the relative abundance of Akkermansia, and low quinoa intake significantly increased the relative abundance of Blautia at the genus level. The relative abundances of Blautia and Dorea in rats in the HF + HQ group were lower than those in rats in the HF + LQ group. In addition, the relative abundances of Clostridium and Turicibacter of rats in the two quinoa intervention groups were lower than those of rats in the HF group after 12 weeks of intervention. In summary, quinoa exhibits a series of beneficial effects in the prevention of nonalcoholic fatty liver disease (NAFLD) and is suggested to be a component of a daily diet for the prevention of NAFLD.

Preparation and bioactivity of the rare ginsenosides Rg3 and Rh2: An updated review.

Ginseng, an ancient medicinal herb, is used in oriental medicine for the treatment of various diseases. Saponins are the main bioactive components of ginseng, but the multiple glucosyl side chains on its molecules prevent ginsenosides from entering the blood through the intestinal membrane, thus reducing the efficacy. The preparation of rare ginsenosides, which are easy to be absorbed by human body and have higher drug activity, has been widely practiced by removing the sugar group of natural ginsenosides in vitro. Rare ginsenosides Rg3 and Rh2 have been approved as drugs or health supplements to improve immune function. This review summarizes the preparation methods of ginsenoside Rg3 and Rh2 in recent years. Ginsenoside Rg3 and Rh2 were prepared by biotransformation of protopanaxadiol type ginsenoside, with the highest conversion rate of 98.19% and 95.89% in the laboratory, respectively. At present, improving the conversion rate and reducing the production cost are still the bottleneck of industrial scale production of Rg3 and Rh2 through the deglycosylation directly from Rb1, Rb2, Rb3, Rc and Rd in the crude extract of ginseng. In addition, ginsenosides Rg3 and Rh2 play anti-inflammatory, anticancer, cardiovascular protective, immunomodulatory, neuroprotective, anti-diabetic, anti-fatigue, anti-allergic, anti-aging, antioxidant and other pharmacological effects by activating AMPK, JNK, NF-κB, MAPKs, P13K/AKT/mTOR and other signaling pathways. As potential drugs for prevention and treatment of various diseases, ginsenoside Rg3 and Rh2 need to further clarify other underlying mechanisms of action through in vitro and in vivo experiments.

Risk assessment of human exposure to airborne pesticides in rural greenhouses.

In comparison to an open field, greenhouses utilize much more pesticides. The non-occupational exposure risk caused by pesticide drift is unknown. In this study, within 8 months (from March 2018 to October 2018), air samples were collected from indoor and outdoor houses and public areas near greenhouses in vegetable growing areas (eggplant, leek, garlic, etc.), and qualitative and quantitative analyses of pesticides were carried out. Using a 95% confidence interval, six pesticides (acetamiprid, difenoconazole, thiazophos, isoprocarb, malathion, and pyridaben) were detected. The results of the safety assessment showed that the non-cancer exposure risk of single pesticides for all residents in the agricultural areas was within the acceptable range, and the excess lifetime cancer risk of all residents inhaling difenoconazole exceeded 1E-6, and the agricultural region urgently needs increased cancer regulatory scrutiny. But combined toxicity of six pesticides not evaluated due to lack of suitable data. Comparison with open field scenes, the results show that pesticide levels to airborne are lower in greenhouse regions.

Immune Responses to HBV Vaccine in People Living with HIV (PLWHs) Who Achieved Successful Treatment: A Prospective Cohort Study.

BACKGROUND: Understanding immune responses after HBV vaccination is important to prevent HBV infection in PLWH and to achieve successful treatment. METHODS: Thirty-two PLWHs with CD4+ cell count > 350 cells/µL and HIV RNA < 200 copies/mL were vaccinated with 20 µg of HBV vaccine at weeks 0, 4, and 24 in this prospective study. We measured total HIV DNA levels, HBsAb titers and HBsAg-specific T-cell responses during follow-up time. RESULTS: All patients achieved protective HBsAb titer after immunization. The magnitude of the IFN-r and TNF-a response to HBsAg was 22.0 (IQR: 6.5-65.0) and 106.50 (IQR: 58.5-203.0) spot-forming cells (SFC)/105 PBMC, respectively at week 0. The level of IFN-r secreted at weeks 12 and weeks 36 to 48 was comparable with that at week 0. However, IFN-r response was higher at weeks 12 than that at weeks 36 to 48 (p = 0.02). The level of TNF-a secreted at weeks 12 was higher than that at week 0 (p < 0.001). Total HIV DNA levels were 2.76 (IQR: 2.47-3.07), 2.77 (IQR: 2.50-3.09), 2.77 (IQR: 2.41-2.89) log10 copies/106 PBMCs at weeks 0, 12, 36 to 48, respectively. No correlation was observed between IFN-r and TNF-a levels and HBsAb titer as well as total HIV DNA levels after immunization. CONCLUSION: Humoral immunity was satisfactory, but cellular immunity and decline in HIV reservoir were not optimal after HBV vaccine immunization in these patients.

The effects of Medicaid expansions on dental services at federally qualified health centers.

BACKGROUND: Federally qualified health centers (FQHCs) have become safety-net providers of dental services for low-income patients. The authors examined the effects of the Patient Protection and Affordable Care Act Medicaid expansions, according to level of dental benefits, on the number of visits for dental services at FQHCs. METHODS: The authors used publicly available facility-level data on 1,400 FQHCs across the United States from the 2011 through 2019 Uniform Data System. The authors used an event-study difference-in-difference design to examine the effects of expanding Medicaid in 2014, according to the level of dental benefits, compared with nonexpansion states. Outcomes included the number of dental visits for any dental service and separately for preventive and other services. Regression models adjusted for the demographic characteristics of the FQHC's patient population, county-level factors, and center and year fixed effects. RESULTS: Expanding Medicaid with extensive dental benefits has increased the number of dental visits provided at FQHCs in 2014 through 2019 from 2013 by 1,329 to 7,647 visits per FQHC on average compared with FQHCs in nonexpansion states. There was an increase in visits for both preventive and other dental services. In contrast, there was no evidence of such an increase from expanding Medicaid with limited or emergency-only dental benefits. CONCLUSIONS: Expanding Medicaid eligibility with extensive dental benefits has increased the number of dental visits at FQHCs, including for both preventive and other dental services. PRACTICAL IMPLICATIONS: As safety-net providers, FQHCs might be able to provide more oral health care for low-income patients after Medicaid expansions that offer extensive dental benefits.

Child Flourishing, School Engagement, Physical Activity, and Screen Time During the Coronavirus Disease 2019 Pandemic in 2020.

OBJECTIVE: To examine changes in flourishing, school engagement, physical activity, and recreational screen time among school-aged children in the United States during the Coronavirus Disease 2019 (COVID-19) pandemic in 2020. METHODS: In this cross-sectional study, data come from the 2018-2020 National Survey of Children's Health for 68,203 children aged 6 to 17 years. Flourishing is always/usually curious to learn, resilient and having self-regulation. School engagement is always/usually completing homework and having interest in doing well in school. Other outcomes are daily 60+ minutes physical activity or number of such days, and daily recreational screen time or 2+ hours/day. Weighted regression models compare 2020 to 2019 and 2019 to 2018 adjusting for child/household covariates and state indicators. RESULTS: Among children age 6 to 17 years in 2020, there was a decline in flourishing (OR = 0.69; 95% CI, 0.63, 0.75), school engagement (OR = 0.71; 95% CI, 0.64, 0.79), physically active days (0.26 days, 95% CI, 35, 0.17), and daily 60+ minutes activity (OR = 0.91; 95% CI, 0.83, 1.00), and increase in daily recreational screen time (0.29 hours; 95% CI, 0.25, 0.34) and 2+ hours/day (OR = 1.65; 95% CI, 1.49-1.83) compared to 2019. These differences were observed across all evaluated demographic and socioeconomics subgroups. There were no significant differences between 2019 and 2018, indicating that the 2020-2019 differences were related to the pandemic rather than a continuation of prepandemic trends. CONCLUSIONS: Children's flourishing, school engagement, and physical activity declined while recreational screen time increased during the COVID-19 pandemic in 2020. Monitoring these outcomes in the long-run is important to assessing needs and promoting children's learning and development.

Hierarchical meso-micro porous FeNC derived from tripolycyanamide-based microporous polymer as efficient electrocatalyst for oxygen reduction reaction.

Designing porous FeNC nanomaterials with highly efficient active sites is an effective strategy for constructing high-performance oxygen reduction reaction (ORR) electrocatalysts. N-containing porous organic polymers (POPs) have emerged as promising candidates for the preparation of porous FeNC catalysts. Here, N-rich tripolycyanamide-based microporous polymer (TCAMP)-coated SiO2 nanospheres (SiO2@TACMP) were prepared as the precursors of an Fe-N doped hierarchical meso-micro porous carbon (Fe-N-HMC) electrocatalyst for the ORR. X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM) characterizations demonstrated that the Fe-N-HMC catalyst possessed a higher content percentage of Fe-Nx active sites and a better distribution of Fe nanoparticles than its Fe-N doped microporous carbon (Fe-N-MC) counterpart. N2 adsorption-desorption isotherm analysis showed that Fe-N-HMC catalyst exhibited a hierarchical meso-micro porous system, with a Brunauer-Emmett-Teller (BET) surface area (SBET) of 733 m2 g-1 (∼2 times of Fe-N-MC's SBET). As a result, Fe-N-HMC catalyst presented a highly efficient ORR performance with a half-wave potential of 0.856 mV, which is similar to the commercial grade 20 wt% Pt/C catalyst and superior to the Fe-N-MC catalyst. Moreover, the as-synthesized Fe-N-HMC catalyst displayed a better durability and methanol tolerance than the commercial Pt/C catalyst. Therefore, Fe-N-HMC shows great promise as an ORR catalyst for fuel batteries and metal-air cells due to its low-cost, high activity, and good stability.