Cardiovascular benefits and safety of sotagliflozin in type 2 diabetes mellitus patients with heart failure or cardiovascular risk factors: a bayesian network meta-analysis.

Background: As an antidiabetic agent, sotagliflozin was recently approved for heart failure (HF). However, its cardiovascular benefits in type 2 diabetic mellitus (T2DM) patients with HF or cardiovascular (CV) risk factors have not been systematically evaluated. The aim of this study is to evaluate the cardiovascular benefits and safety of sotagliflozin in T2DM patients with HF or CV risk factors using Bayesian network meta-analysis. Methods: Data were retrieved from PubMed, Embase, Web of Science, ClinicalTrials.gov, and Cochrane Library from their inception to 16 August 2023. Randomized controlled trials (RCTs) comparing sotagliflozin with a placebo, dapagliflozin, and empagliflozin in adult T2DM patients with HF or CV risks for at least 12 weeks were included in the study. Data analysis was conducted using R 4.2.3 and Stata 17.0. Cardiovascular efficacy outcomes included HF events (hospitalization or urgent visits for HF), MACE (deaths from CV causes, hospitalizations for HF, nonfatal myocardial infarctions, and strokes), cardiovascular death, the decrease in SBP, and weight loss. Safety outcomes are urinary tract infection, diarrhea, and diabetic ketoacidosis. Results: Eleven studies with 30,952 patients were included. Compared to dapagliflozin and empagliflozin, 200 mg of sotagliflozin showed the best effect in reducing HF events [OR (95% CI), 0.79 (0.66, 0.94) and 0.90 (0.63, 1.27)]. Compared to dapagliflozin, 200 mg of sotagliflozin [OR (95% CI), 0.76 (0.66, 0.87)] was superior in preventing MACE. Compared to empagliflozin, 200 mg of sotagliflozin [OR (95% CI), 1.46 (1.04, 2.05)] was inferior in preventing CV death. Sotagliflozin showed a poorer SBP decreasing effect than empagliflozin and dapagliflozin [MD (95% CI), 1.30 (0.03, 2.56) and 2.25 (0.35, 4.14), respectively]. There was no significant difference between sotagliflozin and other interventions in weight loss. Sotagliflozin exhibited no increased risk for diabetic ketoacidosis or urinary tract infection among all interventions, however, it showed a mild risk for diarrhea than placebo [OR (95% CI), 1.47 (1.28, 1.69)]. Conclusion: Sotagliflozin displayed moderate CV benefits and acceptable safety. Sotagliflozin can be one of the recommended options for T2DM patients with HF or CV risk factors, which will be important for evidence-based use of sotagliflozin as well as decision-making of T2DM medication.

Surface defect detection competition with a bio-inspired vision sensor.

This paper reports the background and results of the Surface Defect Detection Competition with Bio-inspired Vision Sensor, as well as summarizes the champion solutions, current challenges and future directions.

Mapping the reaction zones for CdTe magic-sized clusters and their emission properties.

CdTe magic-sized clusters (MSCs) are promising building blocks for semiconductor devices because of their single size, consistent properties, and reproducible synthesis. However, the synthetic conditions for CdTe MSCs vary significantly in different reports, which hinders the general understanding of their formation mechanisms. Here, we employed Cd(oleate)2, trioctylphosphine telluride (TOPTe), and oleylamine, which are commonly used for larger quantum dot (QD) synthesis, as standard reaction precursors, and systematically investigated the effects of solvent, phosphine amount, oleylamine amount, Cd : Te ratio, and temperature on the evolution of MSCs with time. These conditions compose the "reaction coordinates" to map out the "reaction zones" for CdTe MSCs and QDs. We found that CdTe MSCs with the first excitonic transition (E1) at 449 nm can be synthesized in high purity with excess TOPTe using toluene as the solvent at 100 °C. Whereas higher temperature, excess of Cd(oleate)2, or more viscous solvent led to the aggregation of 449 nm MSC into larger magic-sized species with E1 at 469 nm as well as QDs with E1 > 500 nm. Increasing phosphine concentration simply enhanced the rate and yield of CdTe MSCs, while a critical amount of oleylamine was required to "turn on" the MSC formation. Interestingly, the pure 449 nm MSCs were non-emissive, but colorful emissions were observed for the reaction mixtures containing both MSCs and QDs. The emissions could be attributed to a small amount of QDs formed during the reaction. The mapping of reaction zones is a crucial step towards the rational synthesis of CdTe MSCs and further understanding of their formation mechanism.

Core-Shell-Structured Cyclodextrin Metal-Organic Frameworks for Programmable Cargo Release.

With a simple design, different core-shell-structured cyclodextrin metal-organic frameworks (CD-MOFs) can realize delayed release and bimodal release of a monocomponent and ordered release of a bicomponent, which establishes the basis for a future complicated programming cargo release system.