Role of CC-chemokine ligand 2 in gynecological cancer.

Gynecological cancer is one of the most severe diseases that threaten the lives and health of women worldwide. Its incidence rate increases with each passing year and becomes more prevalent among young people. The prognosis of gynecological cancer remains poor despite significant advances in surgical removal and systemic chemotherapy. Several chemokines play a role in the progression of gynecologic cancers. CCL2 (CC-chemokine ligand 2), also termed MCP-1 (monocyte chemotactic protein 1), plays a significant physiological role in monocyte cell migration and the inflammatory response. Recent studies have demonstrated that CCL2 plays a pro-tumorigenic function in the tumor microenvironment. According to previous studies, CCL2 plays a significant role in the occurrence and development of gynecological cancers. Furthermore, recent studies noted that CCL2 could be a potential diagnostic biomarker and prognostic predictor. The purpose of this paper is to review the role of CCL2 in the occurrence and development of gynecological cancers and to discuss the potential therapeutic strategy of CCL2 for gynecological cancers, with a primary focus on breast cancer, ovarian cancer, cervical cancer, and endometrial cancer.

Body image attitude among Chinese college students.

The present study aimed to examine body image attitude in Chinese college students and related psychological consequences. A silhouette-matching test was administered to 425 college students in mainland China. Self-esteem, negative emotions, subjective well-being, and eating-disorder-related weight-controlling behaviors were also measured. Only 12.9% of the participants were satisfied with their figure and the extent of body image dissatisfaction was comparable for both sexes. The majority of the female participants indicated a preference to be more slender. Their ideal figure was underweight and was far smaller than the most attractive female figure chosen by male participants. For male participants, the proportion wanting a fuller figure was comparable to that wanting a slimmer figure. Among female participants, body image dissatisfaction negatively correlated with self-esteem and subjective well-being, and positively correlated with negative emotions. Drive for thinness correlated with eating-disorder-related weight-controlling behaviors not only for females, but also for males. Body image dissatisfaction, as a diagnostic feature for major subtypes of eating disorders, may signal serious concern among Chinese college students.

Facial emotion processing in patients with schizophrenia and their non-psychotic siblings: a functional magnetic resonance imaging study.

BACKGROUND: Previous studies have shown that patients with schizophrenia show abnormalities in brain activation when processing emotional faces. However, very few studies have examined if such abnormalities are also found in non-western patient samples and in at-risk individuals. The current study explored whether patients with schizophrenia and siblings of patients in China would show abnormal brain activation during processing of emotional faces. METHODS: Thirty-six participants (three groups of twelve each of patients with schizophrenia, nonpsychotic siblings, and healthy controls) took part in the study. They were administered a task to judge emotional valence of three types of faces (viz., happy, fearful, and neutral), during fMRI scanning. RESULTS: Results of this study demonstrated that patients with schizophrenia showed abnormalities in the social brain neural circuit during facial emotion processing, in comparison with nonpsychotic siblings and healthy controls. Patients with schizophrenia demonstrated lower activation right superior and middle frontal gyrus, left precentral gyrus, left middle temporal gyrus and left insula in comparison with healthy controls; and showed abnormal activation in bilateral inferior and middle frontal gyri, right orbital frontal gyrus, left superior and middle temporal gyrus, bilateral insula, and right superior parietal gyrus/postcentral gyrus when compared with their nonpyschotic siblings. Meanwhile, patients with schizophrenia showed greater activation in left middle frontal gyrus than healthy controls, and overactivation in bilateral middle frontal gyri, right orbital frontal gyrus and left middle temporal gyrus than their nonpsychotic siblings during processing of fearful faces. Moreover, nonpsychotic siblings seemed to share some similar dysfunctions in processing facial expressions as their psychotic probands, the two groups both showed abnormal activation in precentral and superior frontal gyri, and such abnormal activation lied between patients with schizophrenia and healthy controls. CONCLUSIONS: The current findings support the universality of emotion perception impairments in schizophrenia, and also suggest that facial emotion perception might be a potential endophenotype of schizophrenia.