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1.
Plast Aesthet Nurs (Phila) ; 44(2): 116-123, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38639968

RESUMO

Hypertrophic scars can have significant and far-reaching effects on patients that range from itching to creating difficulty with mobility, all of which can negatively impact the individual's quality of life. A recent study showed that many patients with recent scars report pain, burning, pruritus, erythema, in combination with psychological difficulties that impact bodily movement, choice of clothing, and participation in leisure activities. Botulinum toxin Type A (BoNTA) and intense pulsed light (IPL) have shown promise in treating such scars. We propose a novel treatment protocol involving a 4-week intervention with hyperdiluted BoNTA injections and supplemental treatment with IPL for erythema, and a 6-month scar scale assessment and photographic documentation that occurs before and 6 months after treatment. We report four cases where using hyperdiluted BoNTA, either alone or in conjunction with IPL, substantially reduced scar size, improved overall scar appearance, and diminished erythema in areas on the face and the breasts. Although this report suggests that a schedule of alternating treatments with BoNTA and IPL may be beneficial in reducing scar size and enhancing appearance, further research is necessary to better understand the most effective dosages, the relationship between BoNTA and IPL, and the optimal management of scarring.


Assuntos
Toxinas Botulínicas Tipo A , Cicatriz Hipertrófica , Humanos , Cicatriz Hipertrófica/tratamento farmacológico , Qualidade de Vida , Toxinas Botulínicas Tipo A/uso terapêutico , Dor , Eritema , Prurido
2.
Women Birth ; 35(2): 105-107, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34344635

RESUMO

BACKGROUND: Pre-registration of a clinical trial before the first participant is recruited can help to prevent selective outcome reporting and salami-slicing that can distort the evidence base for an intervention and result in people being offered care or treatment that is not effective. Rates of clinical trial registration in nursing and midwifery are low. AIM: To use a hypothetical example from midwifery practice to illustrate how selective outcome reporting and salami-slicing can distort the evidence base. FINDINGS: A trial of immersion in water during labour and birth is used to consider issues in outcome selection and how researchers may be drawn to switch primary outcomes or report different outcomes across multiple papers. DISCUSSION: In nursing and midwifery science, selective outcome and salami reporting are seemingly common. Prospective trial registration is intended to prevent these practices, enhancing the quality and integrity of the work. CONCLUSION: Clinical trials are a robust form of primary research evidence and directly impact clinical practice. Researchers must ensure their trials are correctly registered and editors need to reconcile submitted papers and registration entries as part of the review process.


Assuntos
Tocologia , Parto , Ensaios Clínicos como Assunto , Feminino , Humanos , Gravidez , Estudos Prospectivos
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