Is it worthwhile using a transcutaneous bilirubinometer in the nursery?

Jaundice is a potential threat to neonatal health and/or life. The advantages and limitations of transcutaneous determination of bilirubin concentration and current devices are briefly discussed in this paper.

Rearfoot posture in subjects with patellofemoral pain.

The relationship between structural foot deformities and excessive subtalar joint pronation as being contributory to patellofemoral pain has not been well documented. It was the purpose of this study to assess the rearfoot posture in patients diagnosed with patellofemoral pain compared with a normal population. In addition, the intratester reliability in obtaining rearfoot measurements was assessed for right and left sides in 21 normal subjects. A goniometer was used to measure rearfoot posture in 30 female subjects (15 with patellofemoral pain and 15 controls). Measurements were taken with the subjects prone and the subtalar joint in neutral. Intraclass correlation coefficients were good for both the right and left measurements (.87 and .86, respectively). A small but significant increase in rearfoot varus was found in the patellofemoral pain group compared with the control group (8.9 vs. 6.8 degrees; p = .0002). These results suggest that increased rearfoot varus may be a contributing factor in patellofemoral pain and should be assessed when evaluating the events at the subtalar joint and the lower extremity. In addition, it has been demonstrated that consistent rearfoot measurements can be obtained by an individual clinician.

Bretylium: relations between plasma concentrations and pharmacologic actions in high-frequency ventricular arrhythmias.

Although it is widely assumed that the early arrhythmogenic and pressor responses to bretylium are caused by catecholamine release from the adrenergic neuron, this assumption has not been systematically studied in humans. Pharmacologic responses to a placebo infusion and 3 separate bretylium infusions (2.5, 5.0, 10 mg/kg over 60 minutes) were assessed in 6 patients with recurrent, nonsustained ventricular tachycardia. Plasma bretylium concentration, blood pressure (BP), plasma norepinephrine (NE) concentration, arrhythmia frequency and adrenergic neuronal blockade (assessed by the presence or absence of reflex venoconstriction) were measured. Adrenergic blockade was seen with every bretylium infusion and at a time when relatively small amounts of bretylium had been administered (range 160 to 750 mg, median 252). Temporal relations (p less than 0.03) were noted among the time of onset of adrenergic neuronal blockade, onset of the pressor response, increase in NE plasma concentration and increase in ventricular arrhythmia frequency. BP responses during the infusions were linearly related to change in plasma NE at the time of development of adrenergic neuronal blockade. Bretylium plasma concentrations higher than 3 micrograms/ml were frequently associated with a short-lived pressor response. There was a significant relation (p less than 0.06) between the increase in plasma NE during the infusion and an increase in ventricular arrhythmia frequency. Reduction in arrhythmia frequency was seen in only 1 patient, beginning 6 hours after the development of adrenergic neuronal blockade.(ABSTRACT TRUNCATED AT 250 WORDS)

Propranolol and depression.

The authors report the cases of 3 patients who had depressive episodes after administration of propranolol for medical illnesses. The depressive episodes were severe, occurred in a dose-dependent manner, and promptly remitted when propranolol was discontinued. Physicians' awareness of this complication, especially in cases of patients with a history of depression, may reduce the occurrence of this drug reaction.