Assuntos
Dermatoses do Couro Cabeludo/diagnóstico , Alopecia/etiologia , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/uso terapêutico , Criança , Líquido Cístico , Células Gigantes/patologia , Granuloma de Células Gigantes/etiologia , Granuloma de Células Gigantes/patologia , Humanos , Injeções Intralesionais , Linfócitos/patologia , Masculino , Dermatoses do Couro Cabeludo/complicações , Dermatoses do Couro Cabeludo/tratamento farmacológico , Dermatoses do Couro Cabeludo/patologia , Triancinolona/administração & dosagem , Triancinolona/uso terapêuticoAssuntos
Antipsicóticos/uso terapêutico , Compostos de Bromo/efeitos adversos , Delusões/tratamento farmacológico , Sulpirida/análogos & derivados , Adulto , Amissulprida , Benzodiazepinas/uso terapêutico , Delusões/induzido quimicamente , Quimioterapia Combinada , Feminino , Humanos , Hipocondríase/tratamento farmacológico , Olanzapina , Sulpirida/uso terapêutico , Resultado do TratamentoRESUMO
INTRODUCTION: Neonatal lupus is rare and cutaneous lesions are usually suggestive of the diagnosis. We describe the case an infant with atypical clinical and histological aspects. CASE REPORT: A female newborn, 6 weeks of life, presented since 3 weeks a papulo-erythematous eruption involving the trunk and the 4 limbs. Cutaneous biopsy showed a dermal infiltrate of mononuclear cells, which corresponded morphologically to lymphocytes. But myelo-monocytic origin was proved by immunostaining. This result could be seen in hematodermia and macrophagic activation syndrome, but we had no clinical sign for these diagnosis. Later, she presented an erythema of the eyelids and erythematous papules of the face leading to suspicion of neonatal lupus. Questioning the mother revealed that she had Raynaud's syndrome since 1995. Antinuclear factors were positive in the patient and her mother, corresponding to antiSSA and antiSSB antibodies. She exhibited cytolytic hepatitis but no congenital heart block. Direct immunofluorescence was negative. The clinical evolution was good with complete clearing of the eruption at the age of 3 months. At 10 months, clinical and biological examinations were normal, with no arguments for haematological disease. DISCUSSION: This observation is original because of the initial papulo-erythematous eruption which is rare in neonatal lupus. Diagnosis was confirmed when specific secondary cutaneous lesions appeared. The biopsy of the first eruption showed a myelo-monocytic infiltrate which has never been described in neonatal lupus. However cutaneous biopsies are rarely performed in neonatal lupus and immunostaining is lacking in the literature.
Assuntos
Lúpus Vulgar , Fatores Etários , Biópsia , Feminino , Seguimentos , Humanos , Lactente , Recém-Nascido , Lúpus Vulgar/diagnóstico , Lúpus Vulgar/patologia , Pele/patologia , Fatores de TempoRESUMO
Eosinophilic pustulosis of the scalp was first described in 1984. It has also been described in other sites than the scalp. We report a case in which the lesions exclusively involved the genitals. A 4-month-old boy presented with papulopustular lesions of the genitals in the form of pyodermitis with a favourable course over several days but which subsequently recurred. A smear of a pustule revealed no signs of scabies or viral, fungal or bacterial infection. Histology showed a non-follicular eosinophilic pustulosis. This case emphasizes the ubiquitous and sometimes misleading nature of eosinophilic pustulosis and the non-follicular nature of the lesions.