Anti-N-Methyl-D-Aspartate Receptor Encephalitis Associated with Mature Ovarian Teratoma in a Young Adolescent: A Case Report.

BACKGROUND: Ovarian teratoma has an uncommon association with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. This is a life-threatening condition, and here, we describe a case of an adolescent girl with anti-NMDAR encephalitis caused by an ovarian teratoma. CASE: A 14-year-old girl presented with acute features of fever, severe headache, altered behavioral changes, delirium, autonomic instability, episodes of seizure, and involuntary movement over a period of 1 month. Upon investigation, electroencephalogram (EEG), computed tomography (CT), and magnetic resonance imaging (MRI) of her brain showed normal findings. Her serum and cerebrospinal fluid were positive for anti-NMDARs, and a diagnosis of anti-NMDAR encephalitis was made, so she received a course of intravenous methyl prednisolone and immunoglobulin and was discharged after her neurological status improved. Upon further workup, she was suspected to have a left ovarian dermoid cyst on transabdominal ultrasonogram, which was an incidental finding. Her tumor marker panel showed normal serum lactate dehydrogenase, beta human chorionic gonadotropin, inhibin, alpha-fetoprotein, and carcinoembryonic antigen and a cancer antigen 125 level of 71.5 U/L. She eventually underwent laparoscopic left ovarian cystectomy and received immunotherapy in the postoperative period. She was discharged in stable condition on postoperative day 4. On histopathological examination, the specimen revealed a mature cystic teratoma with glial component. One year after surgery, the patient has recovered completely and has no residual psychiatric or neurological symptoms. CONCLUSION: Complete recovery after surgery in cases of anti-NMDAR encephalitis with ovarian teratoma emphasizes the need for early recognition of the entity, search for underlying tumor, and tumor removal to improve the prognosis.

Contralateral Fallopian Tube Dermoid Tumor: A Rare Finding in Chronic Tubal Ectopic Gestation.

Mature cystic teratoma is the most common benign tumor of the ovaries in women of reproductive age. Dermoid tumor in an ectopic or aberrant location is usually detected incidentally. The occurrence of a dermoid tumor in the fallopian tubes is extremely rare, with only approximately 75 cases being reported worldwide in the English language literature. This report describes a left-sided fallopian tube dermoid tumor in a 27-year-old woman with chronic right tubal ectopic gestation and discusses its clinical implications. Inspection of the contralateral fallopian tube in a woman with a ruptured tubal ectopic pregnancy is required clinically to rule out bilateral tubal ectopic gestation. Although rare, the ectopic presence of a dermoid tumor in the fallopian tube may be an incidental finding requiring surgical removal.

A Subcentimetric Nodule on the Penile Shaft.

Juvenile xanthogranuloma (JXG) is a benign histiocytic disorder usually affecting the head and trunk region of a child. The isolated occurrence of JXG in the penile shaft of a young adult is hitherto unreported. This lesion is amenable to surgical resection although systemic and/or internal visceral involvement can occur. The clinical differential of this solid cystic lesion may include other solid cystic lesions of the penile shaft, namely, epidermal inclusion cyst. A typical yellowish color can aid in the diagnosis though it is not a constant feature. In this article, we discuss a case of isolated penile JXG in a young adult with salient clinical and histopathological differentials.