RESUMO
We compared the results of clinical and experimental studies of endocrine parameters in patients with myocardial infarction and arterial hypertension and NISAG rats with hereditary stress-induced arterial hypertension during experimental myocardial infarction. Changes in the content of corticosterone, aldosterone, insulin, triiodothyronine, and thyroxin were similar in animals and patients with myocardial infarction and arterial hypertension. The disadaptive course of myocardial infarction against the background of arterial hypertension can be explained by reduced compensatory capacity of the myocardium.
Assuntos
Hipertensão/fisiopatologia , Infarto do Miocárdio/fisiopatologia , Adulto , Aldosterona/sangue , Animais , Pressão Sanguínea , Estudos de Casos e Controles , Modelos Animais de Doenças , Humanos , Hipertensão/genética , Hipertensão/metabolismo , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/sangue , Ratos , Ratos Endogâmicos SHR , Ratos WistarRESUMO
Cold stress in the early postnatal ontogeny caused permanent functional changes in the cardiovascular system, which were different in hypertensive NISAG and normotensive WAG rats. Stress led to elevation of blood pressure and overload on the left heart chambers in adult WAG rats postnatally exposed to cold. At the same time, postnatal exposure to cold stress attenuated functional disturbances typical of hypertensive NISAG rats.
Assuntos
Pressão Sanguínea , Hipertensão/etiologia , Hipertensão/fisiopatologia , Estresse Fisiológico/complicações , Estresse Fisiológico/fisiopatologia , Animais , Temperatura Baixa/efeitos adversos , Eletrocardiografia , Coração/fisiopatologia , Masculino , Ratos , Restrição Física , Sistema Nervoso Simpático/fisiopatologiaRESUMO
The morphological and functional consequences of epinephrine-induced myocardial infarction were studied in normo- (Wistar) and hypertensive (ISIAH) rats. After experimental myocardial infarction there was an irreversible transition to the "worn-out" stage or "plastic damage" to the myocardium. Thus, myocardial hibernation in ISIAH rats anticipates and determines the development of myocardial stunning, i.e., irreversible myocardial damage, whereas in the normotensive animals, the protective effect of hibernation is fully shown. The ontogenetic features of myocardial response of ISIAH rats to hypoxia promote transformation of adaptive hibernation and stunning to maladaptive pathological changes causing hypoxic alterations.