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BMC Vet Res ; 9: 120, 2013 Jun 19.
Artigo em Inglês | MEDLINE | ID: mdl-23777548

RESUMO

BACKGROUND: African swine fever (ASF), a highly contagious fatal acute haemorrhagic viral disease of pigs currently has no treatment or vaccination protocol and it threatens the pig industry worldwide. Recent outbreaks were managed by farmers with ethnoveterinary preparations with various claims of effectiveness. RESULTS: We identified 35 compounds using GC-MS protocol and ASF virus (NIG 99) was significantly reduced by some extracts and fractions of the plant. However, the plant was poorly extracted by water and cytotoxicity was found to be a major problem with the use of the plant since its extracts also reduced the primary cells used in the assay. CONCLUSION: It is confirmed that the plant has antiviral potentials against ASF virus and farmers' claims seem to have certain degree of veracity, but finding the best means of exploring the potential of the plant while reducing its cytotoxic effect in-vitro and in-vivo will be necessary.


Assuntos
Vírus da Febre Suína Africana/efeitos dos fármacos , Febre Suína Africana/tratamento farmacológico , Antivirais/uso terapêutico , Caryophyllaceae/química , Fitoterapia/veterinária , Extratos Vegetais/uso terapêutico , Animais , Cromatografia Gasosa-Espectrometria de Massas , Técnicas In Vitro , Casca de Planta/química , Extratos Vegetais/análise , Folhas de Planta/química , Raízes de Plantas/química , Caules de Planta/química , Reação em Cadeia da Polimerase/veterinária , Reação em Cadeia da Polimerase em Tempo Real/veterinária , Suínos
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