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1.
Clin Neurol Neurosurg ; 243: 108394, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38908321

RESUMO

AIM: Advanced neuroimaging strategies may provide new insights into the underlying mechanisms of trigeminal neuralgia (TN). The objective of this study is to measure central pain centers in patients with long-standing trigeminal neuralgia and compare them to those of normal individuals. The findings of this study could improve the understanding of central region changes related to pain and improve the diagnosis and management of chronic trigeminal pain. MATERIAL AND METHODS: We examined radiologic data from 20 patients with trigeminal neuralgia and 28 healthy controls who underwent 3D iso T1-weighted brain MRI at our university hospital between 2018 and 2023. Patients with a minimum pain duration of 5 years were included and compared with healthy controls. Additionally, patients were categorized into groups based on the presence of vascular compression. The pain-related subcortical structures, such as the cingulate cortex and insula, were analyzed volumetrically using volBrain software. The results were evaluated statistically. RESULTS: Significant differences were observed in the measurement of the posterior insula (p = 0.014) when comparing patients with trigeminal neuralgia and healthy subjects. Additionally, group comparisons based on the presence of vascular compression revealed significant differences in the Middle Cingulate Cortex (0.036) and Posterior Cingulate Cortex (0.031) between groups, which may be related to the etiological factor. CONCLUSION: Understanding changes in central regions related to pain can aid in the diagnosis and management of chronic trigeminal pain.


Assuntos
Giro do Cíngulo , Imageamento por Ressonância Magnética , Neuralgia do Trigêmeo , Humanos , Neuralgia do Trigêmeo/diagnóstico por imagem , Masculino , Feminino , Pessoa de Meia-Idade , Giro do Cíngulo/diagnóstico por imagem , Idoso , Adulto , Córtex Insular/diagnóstico por imagem
2.
J Clin Neurosci ; 123: 157-161, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38579522

RESUMO

BACKGROUND: This study aimed to assess abnormalities in the insular cortex of individuals suffering from migraines and examine their associations with pain duration, medication usage, and clinical symptoms. METHODS: We analyzed radiological data from 38 migraine patients who had undergone 3D iso T1-weighted brain MRI at our university hospital between 2019 and 2023. Structured questionnaires were used to collect information on participants' age, migraine type, disease duration, clinical symptoms, and medication use. Volumetric analysis was performed on the insular regions using Volbrain and 3DSlicer. The results were statistically analyzed. RESULTS: Comparing groups with chronic pain to normal groups revealed significant differences in several insular regions, including the posterior insula (p = 0.034), parietal operculum (p = 0.04), and the entire insular cortex (p = 0.023). Further group comparisons (Group 1, 2, and 3) showed significant differences in specific insular regions. For instance, the anterior insula (p = 0.032) was associated with taste changes, the posterior insula (p = 0.010) with smell-related changes, and the central operculum (p = 0.046) with sensations of nausea. Additionally, significant changes were observed in the parietal operculum concerning nausea, photophobia, phonophobia, and changes in smell. CONCLUSION: To the best of our knowledge, there have been no studies investigating the relationship between clinical manifestations and volumetric correlation. This study provides insights into abnormalities in the insular cortex among migraine patients and their potential relevance to pain duration, severity, and migraine type. The results suggest that understanding alterations in insular regions possibly linked to pain could contribute to the development of innovative approaches to managing chronic pain.


Assuntos
Dor Crônica , Córtex Insular , Imageamento por Ressonância Magnética , Transtornos de Enxaqueca , Humanos , Transtornos de Enxaqueca/diagnóstico por imagem , Feminino , Masculino , Adulto , Pessoa de Meia-Idade , Dor Crônica/diagnóstico por imagem , Córtex Insular/diagnóstico por imagem , Adulto Jovem , Córtex Cerebral/diagnóstico por imagem
3.
Neurosurg Rev ; 47(1): 121, 2024 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-38499891

RESUMO

BACKGROUND: The objective was to provide comprehensive preoperative information on both the aneurysm orientation and the side and method of surgical approach for optimal preoperative information and safe clipping using 3D imaging modalities. This was achieved by making an objective risk assessment on the surgical side/method and evaluating its effectiveness with internal validation. MATERIALS AND METHODS: Radiologic data of 61 ACoA aneurysm patients between 2012 and 2020 were retrospectively analyzed. A scoring system based on five criteria; ACoA aneurysm dome orientation, A1 symmetry/control, perforating artery control, A2 trace orientation, and A2 fork symmetry was developed. The system is designed to align with the most common surgical approaches in ACoA aneurysm surgery. The patients were categorized into three groups based on the scoring results to determine the most appropriate surgical method. Group I was recommended, Group II was less recommended, and Group III was least recommended. Internal validation was performed to assess the system's effectiveness. Outcomes and complication rates were statistically evaluated. RESULTS: When the scoring system was utilized, the mean score difference between the first group and the other groups was 2.71 and 4.62, respectively. There was a homogeneous distribution among the groups in terms of age, sex, WFNS, and Fisher scores. Complication occurred in three patients in Group I and nine patients each in Group II and Group III. The further the deviation from the first option, the higher the complication rate (p = 0.016), and a significant cause-effect relationship was identified (p = 0.021). The ROC curve established a cut-off value of 12.5 points for complications and outcomes. CONCLUSION: Our study introduces a new scoring system for ACoA aneurysms, enhancing the use of 3D CTA in daily practice and providing internal validation for the proposed approach. By evaluating objective criteria, this scoring system helps predict surgical risks, prevent complications, and supports personalized evaluation and selection of the surgical approach based on objective criteria.


Assuntos
Aneurisma Intracraniano , Adulto , Humanos , Criança , Aneurisma Intracraniano/cirurgia , Aneurisma Intracraniano/etiologia , Estudos Retrospectivos , Angiografia Cerebral/métodos , Artérias , Imageamento Tridimensional/métodos
4.
Neurosurg Rev ; 47(1): 39, 2024 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-38200376

RESUMO

Various surgical and anatomical classifications have been proposed to date related to ACoA aneurysm projection. Nonetheless, a universally accepted classification system is yet to be established. This study is aimed at establishing a standardized classification system for ACoA aneurysms with utilization 3D technology and defining reference lines for their projections. The goal is to create a simple, understandable, surgically beneficial, and reliable classification system based on neurovascular structures in the region, including safe and hazardous zones. The radiologic data of 96 patients with ACoA aneurysm who were treated in our university hospital between 2012 and 2020 were retrospectively analyzed, and a planned classification scale was developed with the data obtained. The classification aimed to create 9 main projection groups in the sagittal plane: superior, inferior, anterior, and posterior in linear orientation, and anterosuperior, posterosuperior, anteroinferior, posteroinferior, and complex in quadrant orientation. The coronal and axial planes included medial, lateral, and midline classifications, resulting in a 3-dimensional classification system with 25 projections. Among the 96 patients, 32 had linear and 64 had quadrant projections. In the sagittal plane, the linear projection breakdown was as follows: superior (28%), inferior (6.25%), anterior (53%), and posterior (12.5%). For the quadrant projection, the distribution was as follows: anterosuperior (53%), posterosuperior (12.5%), anteroinferior (21.87%), posteroinferior (3.12%), and complex (9.37%). Overall, 35.4% aneurysms were anterosuperior, 17.7% anterior, 14.58% anteroinferior, 9.37% superior, 8.3% posterosuperior, 6.25% complex, 4.16% posterior, 2.08% posteroinferior, and 2.08% inferior projection. Our study proposes a projection classification that utilizes 3D technology for safe surgery based on neurovascular structures in the region and thus better reveals safe and hazardous zones, including three plans, three dimensions, and two orientations. The use of this classification system offers valuable guidance for daily practice in the treatment of ACoA aneurysms.


Assuntos
Aneurisma Intracraniano , Humanos , Adulto , Criança , Aneurisma Intracraniano/cirurgia , Estudos Retrospectivos , Hospitais Universitários
5.
Turk Neurosurg ; 33(5): 847-854, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37309632

RESUMO

AIM: To define whether characteristics of fluorescein staining help to distinguish low grade gliomas intraoperatively. MATERIAL AND METHODS: We studied 46 patients with supratentorial newly diagnosed noncontrast-enhancing LGGs removed by fluorescence guidance under the YELLOW 560 nm filter. Patients who were treated between July 2019 and 2022 were retrospectively analyzed. Clinical data were collected from patient records. Patients? intraoperative video recordings, pathological examination, and preoperative magnetic resonance imaging (MRI) were analyzed and compared for each patient after the operation. Histopathologically, patients were divided into WHO Grade 2 oligodendrogliomas, diffuse astrocytomas (IDH mutant, 1p19q negative tumors), and pre-glioblastomas (IDH wild type, 1p19q negative tumors). Resection margins were checked using controls contrastenhanced cranial MRI at the postoperative 24 and72 hours. RESULTS: Our observations indicate that fluorescein primarily stains diffuse astrocytomas (IDH mutant, 1p19q negative tumors) and pre-glioblastomas (IDH wild type, 1p19q negative tumors) rather than WHO Grade 2 oligodendrogliomas. CONCLUSION: Fluorescein staining might be an option to determine tumor borders in WHO Grade 2 glial tumors, particularly for those with a higher malignancy potential.


Assuntos
Astrocitoma , Neoplasias Encefálicas , Glioblastoma , Glioma , Oligodendroglioma , Humanos , Oligodendroglioma/diagnóstico por imagem , Oligodendroglioma/cirurgia , Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias Encefálicas/cirurgia , Neoplasias Encefálicas/patologia , Estudos Retrospectivos , Glioma/diagnóstico por imagem , Glioma/cirurgia , Astrocitoma/diagnóstico por imagem , Astrocitoma/cirurgia , Astrocitoma/patologia , Fluoresceínas
6.
Turk Neurosurg ; 33(3): 520-523, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36951028

RESUMO

AIM: To describe a rare case of spondyloptosis caused by spinal tuberculosis in the upper thoracic region. CASE PRESENTATION: A 22-year-old female patient suddenly fell down because of lower extremity weakness. Spondyloptosis was observed, which developed following melting of the spine caused by tuberculosis. Successful reduction, spinal alignment, and stabilization of the spine were achieved following instrumentation with a long-segment screw and rod in a single-stage surgery. CONCLUSION: To the best of our knowledge, this is the first case of spondyloptosis secondary to tuberculosis. This case report highlights the treatment of spinal tuberculosis and surgical deformity correction in a single-stage surgery.


Assuntos
Procedimentos de Cirurgia Plástica , Espondilolistese , Tuberculose da Coluna Vertebral , Feminino , Humanos , Adulto Jovem , Vértebras Lombares/cirurgia , Espondilolistese/cirurgia , Tuberculose da Coluna Vertebral/cirurgia
7.
World Neurosurg ; 170: e603-e611, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36436772

RESUMO

OBJECTIVE: To assess the utility of intraoperative indocyanine green video angiography (ICG-VA) during microsurgical resection of arteriovenous malformations (AVMs). METHODS: Data of the 24 patients, who were surgically treated for AVM using intraoperative ICG-VA, were reviewed retrospectively. Postoperative digital subtraction angiography (DSA) was performed in all patients before they regained consciousness and became fully awake, and the results were compared with those obtained with intraoperative ICG-VA. A scheduled DSA was performed in all patients in the third, sixth, and 12th postoperative months as well. RESULTS: Authors retrospectively analyzed the records of intraoperative ICG-VA application of all 24 patients. Though the exposures were limited and the image qualities were poor at higher magnification on the surgical microscope within deep surgical fields, the AVM niduses, feeding arteries, draining veins, and their relations to normal vasculature were observed precisely with ICG-VA in all the procedures. Furthermore, the visualization was not qualified enough to identify these pathological vascular structures accurately before evacuating and irrigating the layer of blood clots that obscure the view in patients who presented with hemorrhage. In a patient in our series, a residual nidus in the tail of the caudate nucleus was detected with immediate postoperative DSA which was not revealed by terminal assessment with final intraoperative ICG-VA. CONCLUSIONS: Intraoperative ICG-VA is particularly effective in the identification of the feeder, nidus, and drainer and in the assessment of the flow dynamics of the nidus in cerebral AVM surgery. It may be a quick and safe technique for intraoperative imaging of the angioarchitecture of superficial AVMs, but it may be less helpful for deep-seated lesions. Furthermore, this method alone may not be useful in the identification of residual disease or improvement of the clinical outcomes. DSA has remained the gold standard for confirming AVM obliteration. Despite the technical limitations associated with ICG-VA, a combination of intraoperative ICG-VA and immediate postoperative DSA may advance the safety and efficacy of AVM surgery.


Assuntos
Verde de Indocianina , Malformações Arteriovenosas Intracranianas , Humanos , Estudos Retrospectivos , Angiografia Cerebral/métodos , Malformações Arteriovenosas Intracranianas/diagnóstico por imagem , Malformações Arteriovenosas Intracranianas/cirurgia , Angiografia Digital/métodos , Corantes
8.
Turk Neurosurg ; 2023 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-39087289

RESUMO

AIM: Our study focuses on neural tube defects (NTDs), which are central nervous system malformations resulting from incomplete neural tube closure in embryos. We aimed to evaluate tenoxicam's effects on embryonic neural tube formation to identify potential teratogenicity and determine the underlying mechanisms leading to NTD. This study enhances our understanding of embryonic neural tube development and the risks of tenoxicam exposure during pregnancy. MATERIAL AND METHODS: This study was conducted at our University's Neuro-embryology Laboratory. A total of 100 fertile chicken eggs were opened using the windowing method after 24 hours of incubation. The embryo cultures were divided into four groups based on tenoxicam dosage: 0.01, 0.02, 0.10 µg, and control group (0.9% SF was administered). The tenoxicam groups were administered 20 µL volume sub-blastodermally. The eggs were incubated for another 24 hours after being covered with sterile draping. All the eggs were opened at the 48th hour, and the embryos were evaluated. RESULTS: Each group consisted of 25 chicken embryos. Normal neural tube development was observed in Group 1 (0.01µg) with 23 out of 25 embryos, Group 2 (0.02µg) with 20 out of 25 embryos, Group 3 (0.10µg) with 16 out of 25 embryos, and Group 4 (control group) with 24 out of 25 embryos. Additionally, the absence of development rate was 8%, 8%, 12%, and 4% in Groups 1, 2, and 3 and the control group, respectively. CONCLUSION: We observed that tenoxicam use caused midline closure defects in early chicken embryos in a dose-dependent manner. Further studies are required to determine the mechanisms underlying the embryonic damage and teratogenic effects due to genetic and environmental factors and minimize the development of congenital defects.

9.
Asian J Neurosurg ; 17(3): 511-514, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36398170

RESUMO

Posterior reversible encephalopathy syndrome (PRES) is a rare neurologic disorder, having such common radiological findings as vasogenic edema and white matter changes in watershed areas. The clinic and radiological outcome may not be reversible in 10 to 20% of patients, like in the case of our patient. Here, we discuss the pathogenetic factors that are essential in developing PRES after posterior fossa surgery. A 4-year-old female was admitted to our clinic with a recurrent/residual mass in the posterior fossa. She previously underwent posterior fossa surgery three times (for what was diagnosed as anaplastic astrocytoma through pathohistology) in another center. She was operated thrice in 5 days, and the tumor radically removed. Two days later, after the last surgery, while waking up, our patient developed seizures and altered consciousness. Her neurological condition was severe. Magnetic resonance imaging findings were compatible with those of PRES. Our patient had multiple risk factors for PRES that were as follows: multiple posterior fossa surgeries, anamnesis of chemotherapy and radiotherapy, high-dose steroid use, intracranial pressure changes, and hypertensive attacks due to surgical manipulation. In preventing the development of PRES, we should beware of sudden changes in blood pressure during surgery and meticulously manipulate the brain stem to avoid any disturbance of the central nervous system homeostasis. PRES may transform into real encephalopathy. If the patient has some of these risk factors, PRES would probably develop after surgery.

10.
Asian J Neurosurg ; 16(3): 626-629, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34660384

RESUMO

Secondary leptomeningeal gliomatosis is a condition known as a result of invasion of the subarachnoid space or the ventricular system of primary intraparenchymal glioma. In this article, we present a 7-year-old boy presented with neck and back deformity and deterioration of gait. Cranial and spinal magnetic resonance imaging revealed lesions in the supratentorial and infratentorial areas, in the brainstem downward the spinal cord. Disseminated oligodendrogliomatosis is extremely rare and our case we present is the 24th in the literature.

11.
Asian J Neurosurg ; 16(1): 200-203, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34211895

RESUMO

Intravascular papillary endothelial hyperplasia (IPEH) also known as Masson's tumor, is a benign, slow growing, vascular lesion which is seen very rarely and only a few cases have been reported intracranially in the literature. It has been reported at many sites, but the posterior fossa involvement is very rare. The preoperative diagnosis is very difficult, as there is no enough cases to achieve a clear understanding about the details of its radiological findings. Differential diagnosis have to be made especially from angiosarcoma and meningioma. It is curable by total surgical removal. In this article we presented the characteristic clinical, radiological, perioperative and pathological findings in a case of IPEH in an unusual location, origin and behavior. To best of our knowledge, we presented the first case of IPEH originating from tentorium.

12.
Cent European J Urol ; 74(4): 547-551, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-35083075

RESUMO

INTRODUCTION: Spinal cord injury is a major cause of lifelong morbidity and functional micturition problems. Some patients are refractory to the available therapeutics, even when used in combination. In this paper we report our results of using gabapentin as an add-on treatment in refractory overactive detrusor cases secondary to spinal cord injury. MATERIAL AND METHODS: A total of 27 patients who had a spinal cord injury between the levels of the second thoracic and fourth lumbar vertebrae and had an overactive detrusor in urodynamic studies were included in this retrospective study. The patients were selected due to the fact that they also had not responded to a combination of an anticholinergic and mirabegron and had neuropathic pain. Gabapentin treatment was added to the previous therapy. Demographics, previous treatments, chronic conditions, urodynamic findings, clinical and urodynamic responses are reported in this paper. RESULTS: We observed a response to treatment in the urodynamic studies of 11 patients (40.17%), in terms of decreased detrusor contractions, maximal detrusor pressure, and the number of incontinence episodes. Sixteen patients did not respond to the gabapentin add-on therapy and were referred for Botulinum toxin injections to the bladder. CONCLUSIONS: Gabapentin add-on therapy can be considered as a third or further option, before Botulinum toxin injection, for patients with neurogenic overactive detrusor who did not respond to the combination of anticholinergics and mirabegron. The approved usage of gabapentin for neurogenic pain justifies its usage in this area. In our selected patient group, who had not responded to the combination therapy, we observed a clinical benefit in one-third of the patients.

13.
Clin Neurol Neurosurg ; 199: 106262, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-33031992

RESUMO

OBJECTIVE: Chronic subdural hematoma (CSDH) is an important health problem observed mostly in elderly population. Here, we aimed to describe and validate a simple modified technique of twist-drill craniostomy (TDC) using easily accessible tools for effective and safe bedside CSDH drainage. METHODS: A detailed description of the new modified TDC technique which allows for sequential drainage and irrigation under physiological conditions is provided. Clinical and radiological characteristics as well as surgical results of the patients undergoing this procedure are also presented. RESULTS: A total of 55 patients (30 M, 25 F) underwent this modified TDC. Mean age was 61.7 ±â€¯12.3 years. Medical comorbidities were common (76.4 %). Subdural hematoma was mostly unilateral (83.6 %). Maximum width of hematoma was 21 ±â€¯4 mm on average (range: 9-38 mm). In total, patients underwent 1.6 ±â€¯0.9 subdural tappings on average (median: 1, range: 1-5). Repeat tappings were performed in 43.6 % of the patients. No mortality, serious morbidity or infectious complications were noted. Pneumocephalus was either absent or minimal in most cases (96.4 %). Mean length of hospital stay was 4.9 ±â€¯4.0 days (median: 3; range: 2-20 days). The clinical outcomes were favorable in 92.7 % of the patients (no craniotomy required and no symptomatic recurrence detected). CONCLUSION: This modified technique of TDC utilizes easily available tools, yields satisfactory radiological and clinical results, allows repeated tappings even in outpatient settings and can thus be readily applied in every neurosurgical unit across the world. It can be an effective alternative to existing procedures for patients with multiple co-morbidities and/or high anesthesia risk, in emergency conditions and busy neurosurgical centers.


Assuntos
Craniotomia/métodos , Drenagem/métodos , Hematoma Subdural Crônico/diagnóstico por imagem , Hematoma Subdural Crônico/cirurgia , Irrigação Terapêutica/métodos , Idoso , Craniotomia/instrumentação , Drenagem/instrumentação , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Estudos Retrospectivos , Irrigação Terapêutica/instrumentação , Resultado do Tratamento
14.
Turk Neurosurg ; 30(6): 854-863, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32705663

RESUMO

AIM: To assess the classical and functional imaging features of patients with pathology located in the eloquent areas of the brain who were admitted to our centre between October 2012 and February 2018. We also studied intraoperative somatosensory evoked potential (SEP), motor evoked potentials (MEP), phase reversal, cortical mapping, the extent of resection and the calculation of postoperative morbidity. MATERIAL AND METHODS: We compared our results with previous studies in which this technique was not used. The patient records of 163 patients were reviewed retrospectively after approval by the institutional ethics committee and comparisons were made with reports in the literature. RESULTS: The lesion was localised in the visual cortex in eight of the 163 patients. We did not encounter any abnormality in the VEP recordings, so the surgeries were continued. The remaining 155 cases were followed by intraoperative SEP and MEP monitoring. We observed a greater than 50% decrease in the amplitude and an increase in latencies that was greater than 10% in intraoperative MEP and SEP monitoring in 24 patients of 155. Although 8 of 24 patients with abnormal SEP and MEP values were corrected with manuveurs, 6 patients developed increased neurological deficits postoperatively. CONCLUSION: In conclusion, all of these methods should not be seen as competitive with each other; they could be considered as complementary. All of these methods are helpful for a surgical team regarding loss of neurological function. The rate of loss might be up to 100% and irreversible despite corrective maneveurs.


Assuntos
Encefalopatias/cirurgia , Mapeamento Encefálico/métodos , Monitorização Neurofisiológica Intraoperatória/métodos , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos Neurocirúrgicos/métodos , Estudos Retrospectivos
15.
Neurosciences (Riyadh) ; 25(1): 50-54, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31982895

RESUMO

OBJECTIVE: To investigate the treatment of iatrogenic cerebrospinal fluid (CSF) leak that develops after degenerative lumbar spinal surgery with a subfascial drainage and clipping (SDC) technique. METHODS: This study retrospectively reviewed the medical records of 46 patients who developed iatrogenic CSF leak after surgery for lumbar degenerative spine disease from 2007 to 2019. Twenty-five patients were treated with the SDC procedure (SDC group), whereas 21 were not (control group). Outcomes were compared between the two groups. RESULTS: CSF leakage ceased within 6-9 days (average 7.4+/-1) after the procedure in the SDC group. In the control group, CSF leakage was controlled with conservative measures in 14 patients, and in 7 patients, lumbar external drainage was performed. Among these 7, the CSF leak was controlled by lumbar external drainage in 3, and 4 required reoperation to repair the dural defect. No infection occurred in either group. Length of hospital stay was also shorter in SDC group (8.4+/-1 vs 10.0+/-1.3 days, p less than 0.001). CONCLUSION: The SDC technique is effective for the treatment of iatrogenic CSF leak that develops after degenerative lumbar spinal surgery.


Assuntos
Vazamento de Líquido Cefalorraquidiano/cirurgia , Drenagem/métodos , Doenças Neurodegenerativas/cirurgia , Procedimentos Neurocirúrgicos/efeitos adversos , Complicações Pós-Operatórias/cirurgia , Instrumentos Cirúrgicos , Adulto , Idoso , Idoso de 80 Anos ou mais , Vazamento de Líquido Cefalorraquidiano/etiologia , Fáscia , Fasciotomia/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos Neurocirúrgicos/tendências , Complicações Pós-Operatórias/etiologia , Estudos Retrospectivos , Resultado do Tratamento
16.
J Craniovertebr Junction Spine ; 11(4): 342-346, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33824566

RESUMO

Retroclival epidural hematoma in adults is uncommon. Although most cases are associated with craniocervical trauma, other mechanisms have been reported, such as coagulopathy, vascular lesions, and pituitary apoplexy. We report two adults diagnosed with retroclival epidural hematoma. One patient was an 89-year-old male with leukemia and thrombocytopenia who sustained a fall and developed a traumatic retroclival epidural hematoma with brainstem compression; surgery could not be performed due to his clinical condition and he died 5 days later. The other patient was a 78-year-old female with atrial fibrillation who developed a spontaneous retroclival epidural hematoma as a result of warfarin use; she was treated conservatively with anticoagulant reversal and methylprednisolone and was subsequently discharged without neurological deficit. Retroclival hematomas are primarily treated conservatively due to the difficulty of surgical approach. The bleeding mechanism and dural and venous anatomy of this region tend to limit hematoma expansion.

17.
Anticancer Drugs ; 31(5): 533-535, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-31743134

RESUMO

Although giant cell tumor of bone has been considered as a disease with benign course, it can lead to bone destruction and serious morbidity. A 19-year-old case was presented with hip pain. There was a recurrence after 9 months of curative surgical resection and zoledronic acid use, and as surgical morbidity would be high, antiosteoclastic receptor activator of nuclear factor kappa B ligand inhibitor denosumab treatment was administered. She had a complete remission after 18 months of denosumab treatment. The important point in the present case is that it has been followed up without recurrence after around 42 months of denosumab use and 11 months of follow-up after the cessation of drug. In recurrent cases in which nonmetastatic surgery is not suitable, the use of denosumab decreases tumor progression. The duration of use in unresectable and advanced cases still remains unclear.


Assuntos
Conservadores da Densidade Óssea/uso terapêutico , Neoplasias Ósseas/tratamento farmacológico , Denosumab/uso terapêutico , Tumor de Células Gigantes do Osso/tratamento farmacológico , Neoplasias Pélvicas/tratamento farmacológico , Adulto , Neoplasias Ósseas/patologia , Feminino , Tumor de Células Gigantes do Osso/patologia , Humanos , Neoplasias Pélvicas/patologia , Prognóstico , Indução de Remissão , Fatores de Tempo , Adulto Jovem
18.
Neurosciences (Riyadh) ; 24(3): 221-224, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31380822

RESUMO

In the present article, we described a case of treating intractable pain from failed back surgery syndrome (FBSS) and multiple sclerosis (MS) after implantation of spinal cord stimulation (SCS) in a patient. We are reporting a case where SCS has been used for treating a patient with both FBSS and MS.


Assuntos
Síndrome Pós-Laminectomia/terapia , Esclerose Múltipla/terapia , Estimulação da Medula Espinal/métodos , Síndrome Pós-Laminectomia/complicações , Feminino , Humanos , Pessoa de Meia-Idade , Esclerose Múltipla/complicações
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