[Change in urea-forming function of rat liver in the acute and recovery period after radiation exposure]. / Izmenenie mochevinoobrazovatel'noi funktsii pechenii krys v ostrom i vosstanovitel'nom periode posle radiatsionnogo vozdeistviia.

The results of investigations of some metabolites and enzymes of ornithine cycle in total gamma-irradiated rats are presented. It is shown that ionizing radiation furthers the intensification of liver ammonium binding function. It took place without visible enzyme activation during the first period of defeat. The increasing of enzyme activity at the top of pathological process development is also shown. The definite dose-dependence was observed in this period. The month after irradiation the liver function was decreased and during two month after influence the liver function was not normal.

[State of the urea-producing function of the liver in gamma-irradiated rats]. / Sostoianie mochevinoobrazovatel'noi funktsii pecheni u gamma-obluchennykh krys.

The investigations of some metabolites and enzymes of ornithine cycle in irradiated rats were performed. It was shown that ionizing radiation furthered the intensification of liver ammonium-connecting function. It took place without visible enzyme activation during the first period of defeat. It was shown also the increasing of enzyme activity at the top of pathological process development. The definite dose-dependence was observed in this period. The month after irradiation the liver function wasn't normal.

[Metabolic characteristics of the myocardium and muscle tissue of the thigh in rats]. / Metabolicheskie osobennosti myshechnoi tkani serdtsa i bedra u krys.

Myocardium and skeletal muscle of white rats have a number of specific features in metabolism of carbohydrates. The skeletal muscle is characterized by high intensity of glycolytic processes and glycolytic substrate phosphorylation, that is testified to by the activity of the terminal glycolysis stage enzymes (pyruvate kinase, lactate dehydrogenase, its isoenzyme spectrum) and by the content of lactate and pyruvate metabolites. In contrast to skeletal muscles, the activity of NAD-dependent malate dehydrogenase in the myocardium is significant both in cytoplasm and in mitochondria. This activity corresponds to a high level of malate and oxaloacetate metabolites and to the activity of NADP-dependent malate dehydrogenase, playing a connective role between glycolysis, the cycle of tricarboxylic acids and glyconeogenesis. Phosphoenolpyruvate carboxykinase, catalyzing the transformation of cytoplasmatic oxaloacetate into phosphoenolpyruvate is more active in the skeletal muscles where the intensity of the tricarboxylic acids cycle reactions is lower and the activity of glycolysis is higher than that of myocardium.

[Changes in the spectrum of LDH isoenzymes in foci of epileptic activity induced by penicillin in the cerebral cortex of rats]. / Izmeneiia spektra izofermentov LDG v ochagakh épilepticheskoi aktivnosti, vyzvannykh penitsillinom v kore golovnogo mozga krys.

The correlation between electrophysiological changes and isozymes of LDH of the rat brain cortex was studied in seizure foci induced by application of sodium penicillin. It was discovered that activity of LDH1 was suppressed, and that of LDH5 fraction was elevated in the determinant focus, which indicates the enhanced glucose anaerobic transformation. The spectrum of LDH isozymes did not practically differ from the indicators in control animals in a homotopic region of the contralateral hemisphere prior to creation of the mirror focus. The anaerobic processes were found to be increased in the mirror focus and in the determinant one as well. Similar pattern of changes in electrophysiological and neurochemical characteristics in the determinant and dependent mirror foci attests to the formation of a pathological system out of the two epileptic foci.

[Lactate dehydrogenase isoenzyme spectrum in the myocardium and skeletal muscles of animals under physical stress]. / Izofermentnyi spektr laktatdegidrogenazy v miokarde i skeletnykh myshtsakh zhivotnykh pri fizicheskoi nagruzke.

Single physical load (forced run up to fatigue) changes the lactate dehydrogenase activity in the myocardium and skeletal muscles of rats. It is pronounced in a sharp rise of the activity 1 h after the action, in a decrease 6 h after and again in an increase a day later and a gradual fall on the third seventh days. An increase in the portion of isoenzymes typical of the anaerobic metabolism is peculiar to the myocardium and skeletal muscles, that finds its manifestation in both an increase in the lactic acid amount and the lactate/pyruvate coefficient. A regular rise in the LDH2 amount in all periods of the study and LDH5 in the early period after the action is peculiar to the myocardium and the increase in the LDH5 content is characteristic of the skeletal muscles.