RESUMO
Studies of antiexudative, antialterative, and antibacterial effects of lecithin-cholesterol liposomes suggest their possible use as antiinflammatory agents. It is shown that incubation of liposomes with opportunistic microorganisms is attended with a pronounced antibacterial effect, while subcutaneous injection of liposomes significantly reduces the soft tissue edema caused by administration of formalin, and prevents pronounced alteration in response to acetic acid solution. A conclusion is derived on the possibility to use the membranotropic properties of liposomal membranes to alleviate manifestations of inflammation.
Assuntos
Colesterol/uso terapêutico , Edema/tratamento farmacológico , Lipossomos/uso terapêutico , Fosfatidilcolinas/uso terapêutico , Animais , Colesterol/administração & dosagem , Colesterol/farmacologia , Edema/induzido quimicamente , Edema/microbiologia , Escherichia coli/efeitos dos fármacos , Formaldeído , Membro Posterior , Técnicas In Vitro , Inflamação/induzido quimicamente , Inflamação/tratamento farmacológico , Injeções Subcutâneas , Lipossomos/administração & dosagem , Lipossomos/farmacologia , Fosfatidilcolinas/administração & dosagem , Fosfatidilcolinas/farmacologia , Ratos , Ratos Endogâmicos , Staphylococcus aureus/efeitos dos fármacosRESUMO
An analysis of treatment of 85 patients with wounded neck during 20 years has been made. Twenty two patients (25.9%) had no clinical symptoms of injuries of the vitally important organs when admitted to the hospital and stayed under observation. Negative data were found during examination of the wound in 39 of 63 patients (61.9%) operated upon. The authors believe that in most cases no traditional revision of the wound should be performed. Selective tactics and individual approach to treatment of such injuries is necessary.