1.
Bioorg Med Chem Lett
; 17(8): 2305-9, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17280833
RESUMO
4-Amino-5,6-biaryl-furo[2,3-d]pyrimidines were identified as potent non-selective inhibitors of Lck. A novel, divergent, and practical synthetic route was developed to access derivatives from bifunctional intermediates. Lead optimization was guided by X-ray crystallographic data, and preliminary SAR led to the identification of compounds with improved cellular potency and selectivity.