Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Sequenciamento de Nucleotídeos em Larga Escala/métodos , Mieloma Múltiplo/tratamento farmacológico , Neoplasia Residual/fisiopatologia , Idoso , Feminino , Humanos , Masculino , Monitorização Fisiológica , Mieloma Múltiplo/genética , Mieloma Múltiplo/patologia , Análise de SobrevidaRESUMO
The aim of the study was to define the frequency and prognostic significance of acquired chromosomal abnormalities in our adult population and to ascertain whether karyotype represents a significant prognostic factor in adult patients with acute lymphoblastic leukemia (ALL) independently of the new intensive chemotherapy programs and initial clinical characteristics.
Assuntos
Leucemia-Linfoma Linfoblástico de Células Precursoras/diagnóstico , Adolescente , Adulto , Idoso , Aberrações Cromossômicas , Análise Citogenética , Intervalo Livre de Doença , Feminino , Humanos , Cariotipagem , Masculino , Pessoa de Meia-Idade , Leucemia-Linfoma Linfoblástico de Células Precursoras/genética , Prognóstico , Espanha , Taxa de SobrevidaRESUMO
A 7-month-old girl was diagnosed with acute megakaryoblastic leukemia and, at the time of diagnosis, the karyotype was 48-50,XX,+4,+5,del(5)(p13),del(6)(q14), +8,inv(8)(p23.1q13),der(13) t(13;?;?),+19,-20,+21,+22,+mar [cp20]. At relapse, there was clear evidence of her constitutional status as a carrier of the pericentric inversion (8)(p23.1q13). It was a familial inversion affecting the patient's maternal lineage; a history of cancer and bleeding anomalies in carriers of the inversion led us to consider their nonrandom association with these pathologies.