A Glimpse into Chromatin Organization and Nuclear Lamina Contribution in Neuronal Differentiation.

During embryonic development, stem cells undergo the differentiation process so that they can specialize for different functions within the organism. Complex programs of gene transcription are crucial for this process to happen. Epigenetic modifications and the architecture of chromatin in the nucleus, through the formation of specific regions of active as well as inactive chromatin, allow the coordinated regulation of the genes for each cell fate. In this mini-review, we discuss the current knowledge regarding the regulation of three-dimensional chromatin structure during neuronal differentiation. We also focus on the role the nuclear lamina plays in neurogenesis to ensure the tethering of the chromatin to the nuclear envelope.

Mattering, wellness, and fairness: Psychosocial goods for the common good.

Whereas the behavioral and health sciences have been mainly concerned with the private good, there is an urgent need to understand and foster the collective good. Without a coherent framework for the common good, it will be extremely difficult to prevent and manage crises such as pandemics, illness, climate change, poverty, discrimination, injustice, and inequality, all of which affects marginalized populations disproportionally. While frameworks for personal well-being abound in psychology, psychiatry, counseling, and social work, conceptualizations of collective well-being are scarce. Our search for foundations of the common good resulted in the identification of three psychosocial goods: mattering, wellness, and fairness. There are several reasons for choosing them, including the fact that they concurrently advance personal, relational, and collective value. In addition, they represent basic human motivations, have considerable explanatory power, exist at multiple ecological levels, and have significant transformative potential. The complementary nature of the three goods is illustrated in an interactional model. Based on empirical evidence, we suggest that conditions of justice lead to experiences of mattering, which, in turn, enhance wellness. Challenges and opportunities afforded by the model at the intrapersonal, interpersonal, occupational, communal, national, and global levels are presented. The proposed psychosocial goods are used to formulate a culture for the common good in which we balance the right with the responsibility to feel valued and add value, to self and others, in order to promote not just wellness but also fairness. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Dataset on physical properties and mechanical parameters of limestone rocks from Central Apennines (Italy) by laboratory test on intact rock specimens.

Physical properties and mechanical parameters of intact rocks are essential in defining geomechanical characteristics of rock masses. The latter are fundamental in the geotechnical design and numerical modelling of engineering-geological applications involving slope stability analyses as well as the design of dams, foundations, tunnels, open and underground mines, nuclear storage repository etc. Time and financial constraints of many projects often do not allow to perform all the laboratory tests necessary for physical-mechanical characterization of the rock matrix. In these cases, existing published data are the only tools for appropriate definition of the geomechanical characteristics of the intact rocks and subsequent development of engineering-geological performances. This paper reports the values of major physical properties and mechanical parameters for several intact rock samples of limestone, collected from the Central Apennines region (Italy). The main physical properties measured for the rock samples are unit weight, density, and porosity. The mechanical parameters derived from the laboratory tests on the samples include uniaxial compressive strength, cohesion, friction angle, tensile strength, elastic modulus, and Poisson's ratio. Only for a few of samples, the index parameters (point load index) and the dynamic characteristics (P-wave velocity) were also measured. The laboratory tests for these samples were performed following the standards by the International Society for Rock Mechanics (ISRM).

Volunteering in the community: Understanding personal experiences of South Asians in the United Kingdom.

Upstanding civic action is central to individual and community well-being, particularly when communities comprise rich and diverse membership. However, not all groups in society have the same opportunities and resources to volunteer. This is particularly true for South Asian people, who are often reported to be less likely to volunteer. Research into the experience and meanings that this ethnic group attributes to volunteering has been exceptionally scarce. Informed by a community psychology perspective, this qualitative study conducted nine semistructured interviews with British South Asians involved in formal volunteering activities. The aim was to explore their personal experiences and motivations regarding volunteering for their community of belonging. Results from reflexive thematic analysis were grouped under three themes. These were (1) volunteering cultivated individual well-being, (2) South Asians who volunteer often experience social injustice and marginalisation and (3) volunteering for South Asians is intrinsically tied to religious and cultural motivations. British South Asians faced personal and social obstacles in accessing fundamental health and social care in their communities of belonging. Religion, and community social capital were positive volunteering strategies for British South Asians. Positive impacts of well-being included becoming closer to faith and increased sense of meaning/purpose and recognising of individual strengths. These findings offer valuable insights and recommendations for community organisations and governmental bodies to better promote volunteering for ethnic minorities. We suggest the adoption of cultural and religious sensitivity, along with strategies to remove barriers in access to opportunities and support for volunteering.

Introgression of a synthetic sex ratio distortion transgene into different genetic backgrounds of Anopheles coluzzii.

The development of genetically modified mosquitoes (GMM) and their subsequent field release offers innovative approaches for vector control of malaria. A non-gene drive self-limiting male-bias Ag(PMB)1 strain has been developed in a 47-year-old laboratory G3 strain of Anopheles gambiae s.l. When Ag(PMB)1 males are crossed to wild-type females, expression of the endonuclease I-PpoI during spermatogenesis causes the meiotic cleavage of the X chromosome in sperm cells, leading to fertile offspring with a 95% male bias. However, World Health Organization states that the functionality of the transgene could differ when inserted in different genetic backgrounds of Anopheles coluzzii which is currently a predominant species in several West-African countries and thus a likely recipient for a potential release of self-limiting GMMs. In this study, we introgressed the transgene from the donor Ag(PMB)1 by six serial backcrosses into two recipient colonies of An. coluzzii that had been isolated in Mali and Burkina Faso. Scans of informative Single Nucleotide Polymorphism (SNP) markers and whole-genome sequencing analysis revealed a nearly complete introgression of chromosomes 3 and X, but a remarkable genomic divergence in a large region of chromosome 2 between the later backcrossed (BC6) transgenic offspring and the recipient paternal strains. These findings suggested to extend the backcrossing breeding strategy beyond BC6 generation and increasing the introgression efficiency of critical regions that have ecological and epidemiological implications through the targeted selection of specific markers. Disregarding differential introgression efficiency, we concluded that the phenotype of the sex ratio distorter is stable in the BC6 introgressed An. coluzzii strains.

Women's Experiences of Immigration Detention in Italy: Examining Immigration Procedural Fairness, Human Dignity, and Health.

Recent decades have witnessed a growing number of states around the world relying on border control measures, such as immigration detention, to govern human mobility and control the movements of those classified as "unauthorised non-citizens." In response to this, an increasing number of scholars from several disciplines, including psychologists, have begun to examine this phenomenon. In spite of the widespread concerns raised, few studies have been conducted inside immigration detention sites, primarily due to difficulties in gaining access. This body of research becomes even scanter when it comes to the experiences of detained women. This study is the first of its kind to have surveyed 93 women confined in an Italian immigration detention facility. A partial mediation model with latent variables was tested through partial least structural equation modelling (PLS-SEM). The findings revealed the negative impact that unfair immigration procedures have on detained women's human dignity, which in turn negatively affects their self-rated physical and mental health. Overall, our study sheds light on the dehumanisation and damage to human dignity that immigration detention entails, as well as its negative impact on the health of those affected. This evidence reinforces the image of these institutions as sites of persistent injustice, while stressing the need to envision alternative justice-oriented forms to address human mobility.

Between wellness and fairness: The mediating role of autonomous human choice and social capital in OECD countries.

Theoretical arguments and empirical evidence have been provided in the literature for the role of fairness in wellness. In this paper, we explore the role of two potential mediating variables: autonomous human choice and social capital. Using aggregated panel data across countries belonging to the Organisation for Economic Co-operation and Development (OECD), we compared the OECD Social Justice Index (SJI) with data on life satisfaction to test whether fairness has direct and indirect effects on wellness. Results from a series of Manifest Path Analyses with time as fixed effect, support the hypothesis that the OECD SJI is directly linked to country-level life satisfaction, additionally revealing that its indirect effect operates primarily through people's autonomous choices in life and their country's level of social capital. Our results contribute to two distinct bodies of knowledge. With respect to community psychology, the findings offer empirical evidence for the synergistic effect of personal, relational, and collective factors in well-being. With respect to the impact of economic inequality on wellness, we extend the literature by using social justice as a more comprehensive measure. Limitations and recommendations for future studies are discussed.

The I COPPE Scale Short Form for measuring multidimensional well-being: Construct validity and reliability from US, Argentinian, and Italian large samples.

The aim of this study is to present a short form of the I COPPE scale of multidimensional well-being. We conducted two studies, which include four samples collected across three countries, namely United States, Argentina, and Italy. In the pilot study we tested during the data analysis phase whether it was feasible to reduce the full I COPPE scale by omitting the items dealing with past well-being. Prompted by the positive results of the pilot study, we launched a final validation study with a sample of 2682 Italian people who completed the I COPPE scale short form, which is designed without items referring to past well-being. Results from a series of confirmatory factor analyses show that the I COPPE scale short form presents acceptable levels of construct validity and reliability. Moreover, the 7-factor correlated-trait model proved to be the best fit for the data. We discuss advantaged of using the I COPPE scale short form along with limitations and future recommendations.

Mattering Mediates Between Fairness and Well-being.

Research has suggested a fundamental connection between fairness and well-being at the individual, relational, and societal levels. Mattering is a multidimensional construct consisting of feeling valued by, and adding value to, self and others. Prior studies have attempted to connect mattering to both fairness and a variety of well-being outcomes. Based on these findings, we hypothesize that mattering acts as a mediator between fairness and well-being. This hypothesis was tested through Covariance-Based Structural Equation Modeling (CB-SEM) using multidimensional measures of fairness, mattering, and well-being. Results from a Latent Path Analysis conducted on a representative sample of 1,051U.S. adults provide support to our hypothesis by revealing a strong direct predictive effect of mattering onto well-being and a strong indirect effect of fairness onto well-being through mattering. Results also show that mattering is likely to fully mediate the relationship between fairness and multiple domains of well-being, except in one case, namely, economic well-being. These findings illustrate the value of a focus on mattering to understand the relationship between fairness and well-being and to provide future directions for theory, research, and practice. Theoretical implications for the experience of citizenship and participation, along with cross-cultural considerations, are also discussed.

Unbiased logic-tree data for earthquake-induced landslide hazard maps for low-to-moderate magnitude events.

Land-use planning in regard of earthquake-triggered landslides is usually implemented by means of the production of hazard maps. The well-known Newmark rigid block methodology is the most frequent used approach for this purpose. In this method, slope stability is evaluated by the estimation of the Newmark displacement, which is used to set different categories of hazard. This methodology presents limitations due to the difficulty of incorporating the variability of the used variables. For that reason, the logic-tree approach has been used in order to incorporate the epistemic uncertainties and compute probabilistic seismic-landslide hazard maps. However, the used weights in the logic-tree are usually set for each branch based on an expert judgement or subjective criteria. This article provide data obtained from the use of logic-tree methodology; this dataset is useful for deriving the unbiased weights to use in such methodology and in moderate-to-low magnitude scenarios. The data presented here are related to the article entitled "Obtaining suitable logic-tree weights for probabilistic earthquake-induced landslide hazard analyses" (Rodríguez-Peces et al., 2020) [1].

Happiness as fairness: The relationship between national life satisfaction and social justice in EU countries.

Despite growing interest in the relation between social justice and life satisfaction, there is a paucity of quantitative investigations linking these two constructs, even in the field of Community Psychology. To bridge this gap, we tested the relationship between the EU Social Justice Index (SJI; 2008-2017) and life satisfaction across 28 European Union (EU) countries, in a series of multilevel multinomial logistic regression models with cumulative logit link function. The SJI proved one of the strongest predictors of national life satisfaction, after controlling for time variation and other well-established country-level determinants. Our findings lend support to the hypothesis that social justice is highly related to life satisfaction. We invite scholars to explore this relationship further. We also recommend that EU governments strive to promote fairer social conditions to increase national happiness.

"Please mind the gap": successful use of ultrasound-assisted spinal anesthesia for urgent cesarean section in a patient with implanted spinal cord stimulation system for giant chest wall arteriovenous malformation - a case report.

BACKGROUND: The use of Spinal Cord Stimulation (SCS) system to treat medically refractory neuropathic pain is increasing. Severe neuropathic pain can be found in giant chest wall arteriovenous malformations (AVMs), exceedingly rare and debilitating abnormalities, rarely reported during pregnancy. CASE PRESENTATION: We present a report of a pregnant patient with implanted Spinal Cord Stimulation (SCS) system because of painful thoracic AVM scheduled for an urgent cesarean section in which we used lumbar ultrasound (US) to rule out the possibility to damage SCS electrodes and to find a safe site to perform spinal anesthesia. CONCLUSIONS: The use of lumbar US to find a safe site for a lumbar puncture in presence of SCS system in a patient affected by painful thoracic AVM makes this case a particularly unique operative challenge and offers a new possible use of ultrasound to detect a safe space in patients with SCS implant.

Development and evaluation of a web-based software for crash data collection, processing and analysis.

First step of the development of an effective safety management system is to create reliable crash databases since the quality of decision making in road safety depends on the quality of the data on which decisions are based. Improving crash data is a worldwide priority, as highlighted in the Global Plan for the Decade of Action for Road Safety adopted by the United Nations, which recognizes that the overall goal of the plan will be attained improving the quality of data collection at the national, regional and global levels. Crash databases provide the basic information for effective highway safety efforts at any level of government, but lack of uniformity among countries and among the different jurisdictions in the same country is observed. Several existing databases show significant drawbacks which hinder their effective use for safety analysis and improvement. Furthermore, modern technologies offer great potential for significant improvements of existing methods and procedures for crash data collection, processing and analysis. To address these issues, in this paper we present the development and evaluation of a web-based platform-independent software for crash data collection, processing and analysis. The software is designed for mobile and desktop electronic devices and enables a guided and automated drafting of the crash report, assisting police officers both on-site and in the office. The software development was based both on the detailed critical review of existing Australasian, EU, and U.S. crash databases and software as well as on the continuous consultation with the stakeholders. The evaluation was carried out comparing the completeness, timeliness, and accuracy of crash data before and after the use of the software in the city of Vico Equense, in south of Italy showing significant advantages. The amount of collected information increased from 82 variables to 268 variables, i.e., a 227% increase. The time saving was more than one hour per crash, i.e., a 36% reduction. The on-site data collection did not produce time saving, however this is a temporary weakness that will be annihilated very soon in the future after officers are more acquainted with the software. The phase of evaluation, processing and analysis carried out in the office was dramatically shortened, i.e., a 69% reduction. Another benefit was the standardization which allowed fast and consistent data analysis and evaluation. Even if all these benefits are remarkable, the most valuable benefit of the new procedure was the reduction of the police officers mistakes during the manual operations of survey and data evaluation. Because of these benefits, the satisfaction questionnaires administrated to the police officers after the testing phase showed very good acceptance of the procedure.

Thermal Response of Jointed Rock Masses Inferred from Infrared Thermographic Surveying (Acuto Test-Site, Italy).

The Mediterranean region is affected by considerable daily and seasonal temperature variations due to intense solar radiation. In mid-seasons, thermal excursions can exceed tens of degrees thus influencing the long-term behaviour of jointed rock masses acting as a preparatory factor for rock slope instabilities. In order to evaluate the thermal response of a densely jointed rock-block, monitoring has been in operation since 2016 by direct and remote sensing techniques in an abandoned quarry in Acuto (central Italy). Monthly InfraRed Thermographic (IRT) surveys were carried out on its exposed faces and along sections of interest across monitored main joints. The results highlight the daily and seasonal cyclical behaviour, constraining amplitudes and rates of heating and cooling phases. The temperature time-series revealed the effect of sun radiation and exposure on thermal response of the rock-block, which mainly depends on the seasonal conditions. The influence of opened joints in the heat propagation is revealed by the differential heating experienced across it, which was verified under 1D and 2D analysis. IRT has proved to be a valid monitoring technique in supporting traditional approaches, for the definition of the surficial temperature distribution on rock masses or stone building materials.

Measuring subjective well-being from a multidimensional and temporal perspective: Italian adaptation of the I COPPE scale.

BACKGROUND: The objective of this study is to present the psychometric and cultural adaptation of the I COPPE scale to the Italian context. The original 21-item I COPPE was developed by Isaac Prilleltensky and colleagues to integrate a multidimensional and temporal perspective into the quantitative assessment of people's subjective well-being. The scale comprises seven domains (Overall, Interpersonal, Community, Occupation, Psychological, Physical, and Economic well-being), which tap into past, present, and future self-appraisals of well-being. METHODS: The Italian adapted version of the I COPPE scale underwent translation and backtranslation procedure. After a pilot study was conducted on a local sample of 683 university students, a national sample of 2432 Italian citizens responded to the final translated version of the I COPPE scale, 772 of whom re-completed the same survey after a period of four months. Respondents from both waves of the national sample were recruited partly through on-line social networks (i.e. Facebook, Twitter, and SurveyMonkey) and partly by university students who had been trained in Computer-Assisted Survey Information Collection. RESULTS: Data were first screened for non-valid cases and tested for multivariate normality and missing data. The correlation matrix revealed highly significant correlation values, ranging from medium to high for nearly all congeneric variables of the I COPPE scale. Results from a series of nested and non-nested model comparisons supported the 7-factor correlated-traits model originally hypothesised, with factor loadings and inter-item reliability ranging from medium to high. In addition, they revealed that the I COPPE scale has strong internal reliability, with composite reliability always higher than .7, satisfactory construct validity, with average variance extracted nearly always higher than .5, and and full strict invariance across time. CONCLUSIONS: The Italian adaptation of the I COPPE scale presents appropriate psychometric properties in terms of both validity and reliability, and therefore can be applied to the Italian context. Some limitation and recommendations for future studies are discussed.

Comparison between rapid and slow palatal expansion: evaluation of selected periodontal indices.

OBJECTIVES: The aim of this pilot study was to evaluate the periodontal effects during rapid palatal expansion (RPE) or slow palatal expansion (SPE) and to compare them by means of some clinical indices, in order to establish the possible differences and advantages of one of these treatments in periodontal terms. METHODS: 10 patients (aged 6 to 7 years; average age 6.3 years) were submitted to RPE treatment and other 10 patients (aged 6 to 8 years, average age 6.3 years) to SPE treatment. They were treated with the Haas expander. The selected clinical indices (plaque index, PI; papillary bleeding index, PBI; probing pocket depth, PPD) were collected three times during the treatment (t0, detected 7 days after the periodontal prophylaxis, at the beginning of the active orthodontic therapy; t1, detected during the active therapy; t2, detected after retention). All measurements were performed by the same examiner. The protocol was approved by the ethics committee. RESULTS: The effects of the prophylaxis were excellent to control inflammation and dental plaque before the beginning of the orthodontic-orthopaedic treatment, as in both the two groups, the PI and the PBI values were equal to 0.In the group receiving slow expansion, the PPD remained unchanged from t0 to t1, while it significantly increased from t0 to t1 in the group of rapid expansion. At t2 the values of the two groups returned to be overlapping. CONCLUSIONS: Both rapid and slow expansion treatments present potential irritation effect (increase of PI index and PBI index) on the periodontium, suggested by the significant increase of PI and PBI from t0 to t1 in both the two groups; therefore prophylaxis and periodic controls are very important. There are no long-term benefits that might be referred unequivocally to one of the two treatments in terms of periodontal consequences, as demonstrated by the lack of significant differences between the two groups at t2.