RESUMO
The 74 persons, including the 39 persons with mental and behavioral disorders due to psychoactive substance use (PAS) and the 35 persons with subclinical forms of substance use, are examined. The olfactory EEG patterns, differing in narcological patients depending on the range of PAS used, are revealed. EEG markers of olfactory response to isopropanol, thymol and androstenone in combination with emotional evaluation, having hemispheric features, can be diagnostic and differential predictive factors for assessment of predisposition to mental and behavioral disorders due to PAS use.
Assuntos
Sintomas Comportamentais/fisiopatologia , Eletroencefalografia , Transtornos Mentais/fisiopatologia , Córtex Olfatório/fisiopatologia , Psicotrópicos/administração & dosagem , Transtornos Relacionados ao Uso de Substâncias/fisiopatologia , Adolescente , Adulto , Feminino , Humanos , MasculinoRESUMO
The purpose of study was evaluation of extra and intracellular cytokine production in blood cultures and cytokine-pain relationship at different stages od addiction. Methods: Classic and multiplex enzyme immunoassay, flow, cytometry, algometry, visual analogue scale were used in 34 abusers, 12 users and 20 control subjects. Results: Cytokine profile correlated with clinical parameters and pain sensitivity in abusers (mostly IL-6 and IL-1ß). IL-10 production is increased in episodic and systematic users. Activation of intracellular IL-6 synthesis was found in users. Both parameters are expected to affect the emotional evaluation of pain. Conclusion: To assess the predisposition to substance dependence most informative are balance of extra and intracellular production of IL-6 and IL-10 and algometry.
Assuntos
Interleucina-10/sangue , Interleucina-6/sangue , Dor/sangue , Transtornos Relacionados ao Uso de Substâncias/sangue , Adulto , Suscetibilidade a Doenças/sangue , Humanos , MasculinoRESUMO
Change of heart rate variability in orthostatic test and immunologic parameters in healthy persons depend from their anxiety. Anxious persons were characterized by increase of sympathetic nervous activity at baseline and in orthostatic test, stimulation of immunologic parameters. In persons with high trait anxiety and not high state anxiety immunosuppression and failing of sympathetic nervous activity were found. In unanxious persons prevalence of parasympathetic nervous activity in heart rate regulation and intermediate immunologic parameters were revealed.