1.
Bioorg Med Chem Lett
; 19(1): 199-202, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19013793
RESUMO
The P4 region of a series of oxamyl dipeptide caspase inhibitors was optimized by the combination of anti-apoptotic activity in the Jurkat/Fas (JFas) cellular assay and membrane permeability in the PAMPA assay. Two highly potent anti-apoptotic agents with moderate membrane permeability, 29 and 36, showed strong in vivo efficacy in a murine model of alpha-Fas-induced liver injury.