Highlights on the reversible nonpolar-to-polar P3121-P31 phase transition at low temperature in NaLa(SO4)2·H2O: mechanism and piezoelectric properties.

We report the existence in NaLa(SO4)2·H2O of a displacive phase transition under 200 K from the nonpolar P3121 to the polar P31 space group. This phase transition was predicted by density functional theory based calculations and experimentally confirmed from infrared spectroscopy and X-ray diffraction. The A2 polar irreducible representation is the primary order parameter. The structural water and hydrogen bonding are the mechanism driving the phase transition. The piezoelectric properties of this new P31 phase have been investigated by first principles based calculations. The highest piezoelectric-strain constants in the zero Kelvin limit are predicted for the d12 and d41 elements with values about 3.4 pC N-1. This compound could be interesting as piezoelectric actuator for cryogenic applications.

Constraints on WIMP dark matter from the high energy PAMELA p/p data.

A new calculation of the p[over ]/p ratio in cosmic rays is compared to the recent PAMELA data. The good match up to 100 GeV allows us to set constraints on exotic contributions from thermal weakly interacting massive particle (WIMP) dark matter candidates. We derive stringent limits on possible enhancements of the WIMP p flux: a mWIMP=100 GeV (1 TeV) signal cannot be increased by more than a factor of 6 (40) without overrunning PAMELA data. Annihilation through the W+W- channel is also inspected and cross-checked with e+/(e-+e+) data. This scenario is strongly disfavored as it fails to simultaneously reproduce positron and antiproton measurements.

Lipolytic enzymes in Mycobacterium tuberculosis.

Mycobacterium tuberculosis is a bacterial pathogen that can persist for decades in an infected patient without causing a disease. In vivo, the tubercle bacillus present in the lungs store triacylglycerols in inclusion bodies. The same process can be observed in vitro when the bacteria infect adipose tissues. Indeed, before entering in the dormant state, bacteria accumulate lipids originating from the host cell membrane degradation and from de novo synthesis. During the reactivation phase, these lipids are hydrolysed and the infection process occurs. The degradation of both extra and intracellular lipids can be directly related to the presence of lipolytic enzymes in mycobacteria, which have been ignored during a long period particularly due to the difficulties to obtain a high expression level of these enzymes in M. tuberculosis. The completion of the M. tuberculosis genome offered new opportunity to this kind of study. The aim of this review is to focus on the recent results obtained in the field of mycobacterium lipolytic enzymes and although no experimental proof has been shown in vivo, it is tempting to speculate that these enzymes could be involved in the virulence and pathogenicity processes.