A case of long term survival with skeletal only metastatic breast cancer.

INTRODUCTION: The prognosis of patients with metastatic breast cancer is very poor. Because of this, treatment of skeletal metastasis is often palliative with limited goals rather than cure. However, there are those patients, such as presented here, who survive for an extended time. PRESENTATION OF CASE: This thirty-six year old female presented with lytic lesions to one ulna and rib five years after mastectomy for breast cancer. Despite radiation and chemotherapy, the ulnar lesion expanded and resulted in an elbow dislocation. The rib lesion was resected and the arm amputated above the elbow. She developed local recurrence in both her above elbow amputation stump and chest wall and a more proximal below shoulder amputation was performed with resection of chest wall lesion. Even though she had locally aggressive disease, she has survived for 31 years after diagnosis without any evidence of disease. DISCUSSION: Reports of metastatic breast cancer survival indicate the five year survival to be 15%. There have been few reports indicating that those patients with skeletal only or oligometastatic disease have improved prognosis. It is not clear what biological properties of these tumors results in the improved survival. CONCLUSION: This case highlights the challenges of giving patients the optimal treatment in the light of limited ability to predict prognosis. It also highlights the need to further investigate the phenotypes of breast cancer that can, despite metastatic disease and with modern treatment go on to long survival. In addition this case demonstrates the importance of long term followup.

Hip arthroscopic portal bridge retraction technique for improved peripheral compartment visualization.

Hip arthroscopy has been shown to be an effective technique in managing an increasingly widening set of indications for hip pathology. In any arthroscopic procedure, obtaining good visualization is one of the most critical components to performing a successful operation. Whereas other authors have described various techniques for improving visualization, we describe an additional simple but effective technique in this report. We describe the use of a retracting suture bridge between portal sites that allows for improved visualization of the peripheral compartment in hip arthroscopy, as well as other arthroscopic procedures.

Giant clear cell hidradenoma of the knee.

Hidradenomas, also referred to as nodular hidradenomas or clear cell hidradenomas (CCH), are benign cutaneous eccrine tumors usually 2-3 cm in dimension. Hidradenomas are relatively common; however, giant forms are rare. We report a case of an 8.0 x 6.0 x 3.0 cm clear cell hidradenoma of the left knee in a 43-year-old man. The tumor was mobile, located above the patellar tendon and was without bony involvement on imaging studies. Grossly, the resected tumor was unencapsulated and tan, with a solid and cystic cut surface showing papillary excrescences on the cyst wall. Microscopically, the tumor cells showed an infiltrative growth pattern at the periphery, however, the tumor cytology was bland and no necrosis or mitoses were identified. The overlying dermis contained hemosiderin pigment deposition and infiltration with eosinophils. Immunohistochemically, tumor cells were positive for cytokeratin, CAM5.2, p53, carcino-embryonic antigen (CEA) and epithelial membrane antigen (EMA), and negative for CD10 and Ki-67. The cytological features of hidradenomas can present diagnostic challenges, as other 'clear cell' tumors such as metastatic renal cell carcinoma should be considered. Immunohistochemical studies and differential diagnoses are discussed.

Spread of squamous cell carcinoma from the thumb to the small finger via the flexor tendon sheaths.

We report the development of metastatic squamous cell carcinoma at the tip of the small finger following the development of a thumb distal phalanx squamous cell carcinoma caused by chronic osteomyelitis. The spread of hand infections from the flexor tendons of the thumb to the small finger through a tendon sheath connection at the wrist is a well-described phenomenon. The evidence from this case suggests that the spread of the squamous cell carcinoma from the tip of the thumb to the tip of the small finger occurred in a similar fashion. This information is important in understanding how malignant tumors spread in the hand and wrist, and it might influence the management of such tumors.

Safe angle for suture anchor insertion during acetabular labral repair.

PURPOSE: The purpose of this study was to define a safe angle for suture anchor insertion during acetabular labral repair that will facilitate anchor placement within bone and prevent penetration into the hip joint. METHODS: Nine acetabuli were harvested. Anatomic measurements were performed at the anterosuperior quadrant. Electronic calipers were used to measure acetabular bone. "Safe angle" measurements were obtained with suture anchor drills and a protractor. Comparisons between groups were calculated with a 1-way analysis of variance. The Tukey post-hoc analysis was completed for all significant analysis of variance results. RESULTS: Labral insertion point distances and acetabular bone widths at the labral insertion did not statistically differ. Mean "danger angles" ranged from 17.0 degrees to 23.8 degrees. Safe angle measurements ranged from 20.1 degrees to 27.6 degrees. CONCLUSIONS: The extracapsular labral insertion, located between 2.3 and 2.6 mm from the rim of the anterosuperior acetabulum, is offered as a starting point for insertion of anchors sized less than 3.0 mm. The danger angle and safe angle of anchor insertion serve as guidelines that may improve fixation in bone and lessen intra-articular penetration. A target angle of 10 degrees is recommended. CLINICAL RELEVANCE: The danger angle and safe angle may be referenced intraoperatively, during imaging and suture anchor insertion, to assure anchor placement within bone and prevent intra-articular penetration. A target angle of 10 degrees is safe and easily remembered.

Case reports: Osteogenic sarcoma of the patella spread to lateral meniscus after arthroscopy.

Our patient presented with a rare lesion, a patella osteogenic sarcoma that spread to the anterior horn of the lateral meniscus via the arthroscope. He was treated arthroscopically for a torn medial meniscus of his right knee. A lesion in the patella was observed and a biopsy specimen was obtained through the arthroscope. The specimen was diagnosed as an osteogenic sarcoma. After 2 weeks of neoadjuvant chemo-therapy, the patient refused additional chemotherapy. Re-section of the knee and allograft arthrodesis were done 4 months after the initial arthroscopy. Pathologic examination of the resected specimen showed osteogenic sarcoma of the patella and a completely separate 1.0-cm nodule of osteogenic sarcoma tissue growing in the anterior horn of the lateral meniscus. The patient died 15 months after knee re-section with multiple pulmonary metastases. We are unaware that such an occurrence of an osteosarcoma spread through an arthroscope has been documented pathologically and reported.