RESUMO
This study was designed to determine chronic effect of high sucrose low magnesium (HSLM) diet in weanling rats on plasma thyroid profile, catecholamines and activities of key hepatic glycolytic, and gluconeogenic enzymes. Compared to control diet fed group, significantly elevated levels of plasma triiodothyronine, tetraiodothyronine, catecholamines (epinephrine, norepinephrine, and dopamine) and activity of hepatic glycolytic (hexokinase and glucokinase), and gluconeogenic (glucose-6-phosphatase) enzymes were observed in high sucrose and low magnesium fed groups. However, HSLM diet had an additive effect on all these three parameters. The study thus, assumes significance as it shows that hormonal imbalance and disorders in carbohydrate metabolism at an early stage of development can be due to dietary modification or due to deficiency of key element magnesium.
Assuntos
Metabolismo dos Carboidratos/fisiologia , Carboidratos da Dieta/metabolismo , Hormônios/metabolismo , Magnésio/metabolismo , Sacarose/metabolismo , Ração Animal , Animais , Catecolaminas/sangue , Catecolaminas/metabolismo , Dieta/métodos , Glucoquinase/sangue , Glucoquinase/metabolismo , Glucose-6-Fosfatase/sangue , Glucose-6-Fosfatase/metabolismo , Glicólise , Hexoquinase/sangue , Hexoquinase/metabolismo , Fígado/enzimologia , Fígado/metabolismo , Masculino , Ratos , Ratos Wistar , Tri-Iodotironina/sangue , Tri-Iodotironina/metabolismoRESUMO
Increased lipid peroxidation and reduced glutathione levels in liver of rats fed high sucrose high fat (HSHF) diet were normalized by concomitant administration of (+)-catechin hydrate. Plasma non-enzymatic antioxidants viz. alpha-tocopherol, ascorbic acid and total thiols decrease were also significantly less in rats administered with (+)-catechin hydrate concomitantly with HSHF diet. Thus the present results indicate that (+)-catechin hydrate has antioxidant activity and is effective in reducing oxidative stress. The study is of clinical importance as oxidative stress is known to be the cause of many clinical manifestations viz. cancer, Parkinson's disease, atherosclerosis, heart failure, myocardial infarction and many other diseases.