Changes in capillary permeability during severe experimental acute pancreatitis in rats.

Abnormalities of microcirculation are thought to have an important role in the pathogenesis of severe acute pancreatitis (SAP) and in the associated multiple organic failure. We studied changes in capillary permeability during experimental SAP in rats. Necrotizing acute pancreatitis was induced by retrograde injection of sodium taurocholate in pancreatic ducts in rats (n = 30). The animals were distributed in three groups in which the spaces of compartmental distribution as well as the tissue distribution of labeled tracers were evaluated with the use of erythrocytes and albumin tagged with radioactive chromium, apart from determining the volume of total body water. All the studies were carried out four hours after the induction of acute pancreatitis and the administration of radioactive tracers.

[Cordocentesis and evaluation of fetal wellbeing in a very high-risk population (a very reliable index)]. / Cordocentèse et évaluation du bien-être foetal dans une population à très haut risque. (Un index de grande fidélité).

In a population of 57 very high-risk pregnant women (severe clinical history and/or compromised fetus). A total of 240 tests for antepartum fetal evaluation were performed: baseline cardiotocography (CTG), biophysical profile scoring (BPS), doppler-velocimetry of umbilical artery and determination of blood gas analysis in venous umbilical cord blood obtained by cordocentesis. The results of the CTG, BPS, and umbilical artery doppler velocimetry showed a significant relation with those of pH and pO2. The sensitivity, specificity, false-abnormal value, and false-normal value of the CTG, PBS, and doppler velocimetry, used for the diagnosis of fetal acidosis, hypoxia, and asphyxia were comparable. The rate of fetal (asphyxia) was high if present severe/terminal CTG (85.0%), abnormal (4) BPS (82.0%), or absent-end diastole in umbilical artery doppler velocimetry (74.0%). The immediate complication rate due to cordocentesis procedure was minimal.

Niveis sericos de gastrina, calcio, fosforo e creatinina em pacientes portadores de insuficiencia renal cronica. / Seric levels of gastrin, calcium, phosphorus and creatinine in patients with chronic renal faillure

Os AA. dosaram gastrina serica em 41 pacientes portadores de insuficiencia renal cronica (IRC), em regime de hemodialise.Os valores medios normais de gastrina foram avaliados em grupo controle de dez individuos. Na IRC a gastrina media foi de 234,05 + ou - 285,05 pg/ml, contra 47,90 + ou - 28,16 pg/ml entre os normais, nao havendo diferenca estatisticamente significante entre os grupos. Entretanto, a distribuicao de valores normais e anormais nos dois grupos revelou-se significante pelo teste exato de Fischer. Analisam o papel do calcio, fosforo e creatinina, nao atribuindo ao calcio, em termos de hiperparatireoidismo secundario, o papel modulador da elevacao da gastrina. Os valores medios do calcio tenderam a limites relativamente baixos, com elevacao do fosforo.O papel da gastrinemia elevada nos renais cronicos, no que diz respeito a gastropatia uremica, ainda nao esta suficientemente esclarecido

Contribuicao ao estudo radiologico da gastrite cronica superficial. / Radiological study of chronic superficial gastritis

Os autores, utilizando o metodo radiologico de duplo contraste, estudaram as alteracoes encontradas na gastrite cronica superficial.A validade do metodo foi enfatizada, visto o grande indice de acertos no diagnostico. Correlacionaram ainda os aspectos radiologicos com a endoscopia e histologia em 31 pacientes, concluindo que o desaparecimento das pregas mucosas e o aparecimento de areas gastricas intumescidas sao de fundamental importancia para o diagnostico dos processos inflamatorios da mucosa gastrica