The Road to Becoming a World Champion in Futsal.

PURPOSE: The aim of the current study was to report the training program and monitoring outcomes of the Portuguese national futsal team during the preparation and competition phases of the FIFA Futsal World Cup Lithuania 2021™. For that, the variations in training load and wellness were measured, as well as their relationship. METHODS: The study followed a retrospective cohort design. For all field training sessions, the volume, exercise structure, and area of play were identified. Player load, session rating of perceived exertion (sRPE), and wellness were collected. Descriptive statistics and Kruskal-Wallis tests were used for comparison purposes. A visualization method was used for load and well-being. RESULTS: No significant differences were observed in the number of training sessions, session duration, and player load between preparation and competitive periods. sRPE showed significantly higher values in preparation than in competition periods (P < .05, d = 0.86) and significant differences between weeks (P < .05, d = 1.08). Wellness showed a general statistical difference between periods (P < .001, d = 1.28) and weeks (P < .05, d = 1.17). The correlation analysis for the overall period revealed a general linear relationship within variables of training load and wellness (P < .001). Variations occurred for preparation and competition periods. The visualization method through quadrant plots allowed us to understand the adaptation of the team and the players over the specific period under analysis. CONCLUSIONS: Through this study, it was possible to better understand the training program and monitoring strategies of a high-performance futsal team over a high-level tournament.

Bispecific T-Cell Engagers Therapies in Solid Tumors: Focusing on Prostate Cancer.

Over the past decade, immunotherapy has demonstrated an impressive improvement in treatment outcomes for multiple cancers. Following the landmark approvals for use of immune checkpoint inhibitors, new challenges emerged in various clinical settings. Not all tumor types harbor immunogenic characteristics capable of triggering responses. Similarly, many tumors' immune microenvironment allows them to become evasive, leading to resistance and, thus, limiting the durability of responses. To overcome this limitation, new T-cell redirecting strategies such as bispecific T-cell engager (BiTE) have become attractive and promising immunotherapies. Our review provides a comprehensive perspective of the current evidence of BiTE therapies in solid tumors. Considering that immunotherapy has shown modest results in advanced prostate cancer to date, we review the biologic rationale and promising results of BiTE therapy in this clinical setting and discuss potential tumor-associated antigens that may be integrated into BiTE construct designs. Our review also aims to evaluate the advances of BiTE therapies in prostate cancer, illustrate the major obstacles and underlying limitations, and discuss directions for future research.