1.
Org Lett
; 26(7): 1489-1494, 2024 Feb 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38358098
RESUMO
A novel approach using aromatic amines and chiral phosphoric acids in a synergistic catalytic cascade reaction of 2-alkynylnaphthols with aldehydes has been established. This method offers a direct route to preparing flavanone analogues with excellent stereoselectivity. Mechanistic studies reveal a sequential process involving addition, elimination, cyclization, and hydrolysis in which aromatic amines and chiral phosphoric acids play key roles via imine-enamine and hydrogen bonding models.