[Long-term results of formaldehyde]. / Otdalennye éffekty formal'degida.

General and relatively specific regularities in changes of metabolic reactions (according to the activity of certain enzymes of lysosomes, mitochondria, liver and blood serum sialoglycoproteins content, urine excretion of glycoconjugates) in sexually non mature rat offspring, chemically exposed during embryogenesis, were detected.

[Study and evaluation of the health status of various population groups exposed to environmental factors]. / Izuchenie i otsenka sostoianiia zdorov'ia razlichnykh kontingentov naseleniia pri vozdeistvii faktorov okruzhaiuschei sredy.

The system of indicators for monitoring the early and prepathologic body reactions due to the strength and duration of environmental effects of various nature was experimentally developed. The study of the health status of specific population groups provided the approbation results for the recommended biochemical indicators.

[Comparative biochemical and electron microscopic research on the membrane-damaging action of a chemical carcinogen on the endoplasmic reticulum in vivo and in vitro]. / Sravnitel'noe biokhimicheskoe i élektronno-mikroskopicheskoe issledovanie membranopovrezhdaiushchego deistviia khimicheskogo kantserogena na éndoplazmaticheskii retikulum in vivo i in vitro.

The results of a comparative biochemical and electron-microscopic study of membrane-injuring effect of N-nitrosodimethylamine--a chemical carcinogen widespread in the environment are reviewed. It has been established that in vivo and in vitro membrane-injuring effect of nitrosodimethylamine is characterized by reduced activity of membrane-bound enzymes of endoplasmic reticulum (UDP-glucuronyltransferase and glucose-6-phosphatase) accompanied by alterations in functional morphology of cells and intracellular structure.

[Role of substance P in regulating the feeding behavior and the avoidance reaction in the rabbit]. / Rol' veshchestva P v reguliatsii i pishchevogo povedeniia i reaktsii izbeganiia u krolikov.

Similar changes in feeding and avoidance reaction in spite of the way of substance P administration (30 mgk/kg intravenously or 14,8 nmol intraventricular) were found in rabbits with electrodes implanted in various limbic-midbrain structures. Feeding was found to be more sensitive to substance P administration, as it was shown by the decrease of excitability of the hypothalamic "feeding center" and abolishing of the inhibitory and facilitatory effects on this center from the dorsal hippocampus and the midbrain reticular formation, correspondingly. New cortical-subcortical integration under substance P was presented in new characteristics of EEG activity in neocortical areas, both background and in response to stimulation of various limbic-midbrain structures. Biochemical data let to suggest that at the neural level substance P led to destabilization of membrane structures in endoplasmatic reticulum and to redistribution of membrane-connected N-acetylneuramine acid which was directly involved in neurotransmission.

Theoretical substantiation and recommendations of a system of biochemical criteria for the evaluation of the pre-pathological state due to the membrane-damaging effect of environmental factors.

Generalizations derived from experimental studies of enzymic disorganization and stability of membranes of cellular structures (microsomes, mitochondria, lysosomes, cytoplasmic membrane) of various organs and systems (liver, kidney, lung, brain, placenta, gonads, alveolar macrophages and others) due to hepato-, neuro-, gonado-, embryotoxic, mutagenic and carcinogenic effect of chemical pollutants of the environment are presented. Evaluation of the membrane-damaging effect taking into account the stage of labilization of biomembranes (according to severity of manifestation) and compensatory defence reactions at the moleculo-cellular level (alveolar macrophages) is recommended. Classification of biochemical methods (according to priority) is proposed for the evaluation of early functional changes during the examination of the health state of the population in dependence on the effect of environmental factors.

[Effect of ethanol on central mechanisms of alimentary and defensive motivation in the rabbit]. / Vliianie étanola na tsentral'nye mekhanizmy pishchevoi i oboronitel'noi motivatsii krolikov.

A single intravenous administration of ethanol (0.5 g/kg) to rabbits had different effects on the excitability of feeding and defensive motivational centers of the lateral and ventromedial hypothalamus. Ethanol abolished both inhibitory effects of the dorsal hippocampus and facilitatory action of the midbrain reticular formation on alimentary and defensive motivations. It elicited new power distributions of the main rhythms of general electrical cortical activity in the background and under stimulation of limbic-midbrain structures. Analysis of the activity of organello-specific enzymes in limbic-midbrain neurones revealed disturbances of cellular energetic processes caused by ethanol.