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Mol Neurobiol ; 59(12): 7354-7369, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36171480

RESUMO

Intrahippocampal pilocarpine microinjection (H-PILO) induces status epilepticus (SE) that can lead to spontaneous recurrent seizures (SRS) and neurodegeneration in rodents. Studies using animal models have indicated that lectins mediate a variety of biological activities with neuronal benefits, especially galectin-1 (GAL-1), which has been identified as an effective neuroprotective compound. GAL-1 is associated with the regulation of cell adhesion, proliferation, programmed cell death, and immune responses, as well as attenuating neuroinflammation. Here, we administrated GAL-1 to Wistar rats and evaluated the severity of the SE, neurodegenerative and inflammatory patterns in the hippocampal formation. Administration of GAL-1 caused a reduction in the number of class 2 and 4 seizures, indicating a decrease in seizure severity. Furthermore, we observed a reduction in inflammation and neurodegeneration 24 h and 15 days after SE. Overall, these results suggest that GAL-1 has a neuroprotective effect in the early stage of epileptogenesis and provides new insights into the roles of exogenous lectins in temporal lobe epilepsy (TLE).


Assuntos
Epilepsia do Lobo Temporal , Fármacos Neuroprotetores , Estado Epiléptico , Ratos , Animais , Fármacos Neuroprotetores/farmacologia , Fármacos Neuroprotetores/uso terapêutico , Fármacos Neuroprotetores/metabolismo , Galectina 1/farmacologia , Galectina 1/uso terapêutico , Galectina 1/metabolismo , Ratos Wistar , Estado Epiléptico/tratamento farmacológico , Estado Epiléptico/metabolismo , Pilocarpina , Epilepsia do Lobo Temporal/tratamento farmacológico , Epilepsia do Lobo Temporal/metabolismo , Convulsões/metabolismo , Hipocampo/metabolismo , Modelos Animais de Doenças
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