1.
Arch Virol
; 168(7): 179, 2023 Jun 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37310539
RESUMO
Bluetongue virus (BTV) causes bluetongue disease in ruminants and sheep. The current live attenuated and inactivated vaccines available for prevention pose several risks, and there is thus a need for vaccines that are safer, economically viable, and effective against multiple circulating serotypes. This work describes the development of recombinant virus-like particle (VLP) vaccine candidates in plants, which are assembled by co-expression of the four BTV serotype 8 major structural proteins. We show that substitution of a neutralising tip domain of BTV8 VP2 with that of BTV1 VP2 resulted in the assembly of VLPs that stimulated serotype-specific antibodies as well as virus-specific neutralising antibodies.
Assuntos
Vírus Bluetongue , Bluetongue , Vacinas de Partículas Semelhantes a Vírus , Animais , Ovinos , Vírus Bluetongue/genética , Anticorpos , Bluetongue/prevenção & controle , Sorogrupo , Vacinas de Partículas Semelhantes a Vírus/genética
2.