RESUMO
White blood cells have a potential role in the pathogenesis of vasculopathy in diabetic patients. We studied the circulating peripheral blood in a cohort of patients with documented ischemic heart or brain disease with and without type 2 diabetes by means of image analysis and flow cytometry. Our study showed that the state of leukocyte adhesiveness/aggregation is slightly increased in those who had concomitant diabetes but that there was no difference regarding the expression of CD11b/CD18 and CD62L antigens on the surface of the peripheral blood white blood cells. The finding of a significantly increased number of white blood cells in the peripheral blood of patients with ischemic vascular diseases is important insofar as it is associated with a poorer prognosis.
Assuntos
Adesão Celular , Diabetes Mellitus Tipo 2/sangue , Isquemia/sangue , Leucócitos/fisiologia , Idoso , Isquemia Encefálica/sangue , Isquemia Encefálica/complicações , Antígenos CD11/sangue , Antígenos CD18/sangue , Diabetes Mellitus Tipo 2/complicações , Feminino , Humanos , Isquemia/complicações , Selectina L/sangue , Leucócitos/imunologia , Masculino , Pessoa de Meia-Idade , Isquemia Miocárdica/sangue , Isquemia Miocárdica/complicações , PrognósticoAssuntos
Custos de Medicamentos/legislação & jurisprudência , Legislação de Medicamentos , National Institutes of Health (U.S.)/legislação & jurisprudência , Preparações Farmacêuticas/economia , Apoio à Pesquisa como Assunto/legislação & jurisprudência , Transferência de Tecnologia , Universidades/legislação & jurisprudência , Financiamento Governamental/legislação & jurisprudência , National Institutes of Health (U.S.)/economia , Patentes como Assunto , Política , Estados Unidos , Universidades/economiaRESUMO
BACKGROUND: Myocardial function is altered by many factors present in hemorrhaged and resuscitated animals. The purpose of this study was to determine whether resuscitation after a short period of hemorrhagic shock, which by itself did not alter intrinsic cardiac function, causes dysfunction. METHODS: Guinea pigs were instrumented to measure blood pressure and cardiac output, and several days later 50% of their blood volume was removed at a rate of 1 mL/min. Some animals were resuscitated with the shed blood and some with 6% dextran. Hearts were studied 1 or 24 hours after resuscitation. RESULTS: Isolated hearts from animals after 1 hour of resuscitation demonstrated dysfunction whether resuscitated with blood or dextran, although dysfunction was more severe with blood resuscitation. By 24 hours, dysfunction was essentially reversed. CONCLUSIONS: Resuscitation after hemorrhagic shock caused injury to the myocardium independent of the hemorrhage. Blood resuscitation resulted in greater dysfunction than did resuscitation with dextran.