Assuntos
Subunidades alfa de Proteínas de Ligação ao GTP/genética , Melanoma/genética , Mutação , Nevo Azul/genética , Fosfoproteínas/genética , Fatores de Processamento de RNA/genética , Neoplasias Cutâneas/genética , Idoso , Biomarcadores Tumorais , Feminino , Humanos , Neoplasias Hepáticas/secundário , Metástase Linfática , Melanoma/patologia , Pessoa de Meia-Idade , Nevo Azul/patologia , Neoplasias Cutâneas/patologiaRESUMO
BACKGROUND: Indolent non-epidermotropic CD8+ lymphoid proliferation of the ear was recently reported in the literature by Petrella et al. This is a distinct entity related to cutaneous T-cell lymphomas. Herein, we report a case of indolent CD8+ lymphoid proliferation of the ear involving the nasal crest and we relate a number of cases recently published in the literature. PATIENTS AND METHODS: An 87-year-old woman consulted for a pigmented papular lesion of the nasal crest present for 9 years that had begun to regress spontaneously. The remainder of the examination revealed nothing of note. The biopsy showed dense lymphoid infiltration within the dermis. Immunohistochemical analysis supported the diagnosis of indolent CD8+ lymphoid proliferation. Treatment with moderate topical corticosteroids was initiated. DISCUSSION: This novel entity is characterised by the presence of relatively non-symptomatic infiltrated lesions in the ear, which can occur bilaterally. Histological findings are frequently worrying with the presence of a dense cellular infiltrate comprising a relatively monomorphous population of CD8+ lymphocytes, although progression is usually indolent.