RESUMO
We studied allergenic, immunogenic, and skin-irritating effects of deicing chemicals HCM (Volgograd), Bishofit (Turkmenia), and Nordix-P (Russia) in model experiments on various types of laboratory animals (rats, mice, rabbits). All the studied deicing chemicals exhibited weak immunotoxic activity and in high doses can cause delayed-type hypersensitivity reaction that manifested in skin irritant effect on the skin and produced a suppressive effect on the humoral immunity. The modified method for assessing skin irritation proposed by us is more sensitive than standard methods.
Assuntos
Alérgenos/farmacologia , Glicerol/farmacologia , Hipersensibilidade Tardia/induzido quimicamente , Irritantes/farmacologia , Sais/farmacologia , Animais , Feminino , Cobaias , Humanos , Hipersensibilidade Tardia/imunologia , Imunidade Humoral/efeitos dos fármacos , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Coelhos , Ratos , Federação Russa , Pele/efeitos dos fármacos , Pele/imunologia , Meios de TransporteRESUMO
The analysis of works on the study of the hyperreactivity of the human organism to the chemical factors of environment testifies about the significance of the development of this direction in hygienic studies. During rate setting of the content of chemical substances the effect of hypersensitivity to the factors of environment is limiting. In hygienic studies up to now non allergic hypersensitivity (pseudo-allergic response) was not considered, its prevalence among working-age population was not studied and no system of the differential estimation of true allergy and pseudo-allergic response for the practical use in the inspections of population was developed.