1.
ACS Omega
; 5(25): 15631-15656, 2020 Jun 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32637839
RESUMO
Synthesis of 2,3-disubstituted 4-ethoxycarbonyl-ß-carbolin-1-ones is developed using palladium-catalyzed intramolecular amination of 3-amino-4-(2-bromophenyl)-2-pyridones prepared by the conjugate addition reaction of diethyl 2-aminomalonate to alkynyl imines. The method was applied to the total syntheses of SL651498 exhibiting anxiolytic activity and its analogue.