A method of crack detection based on digital image correlation for simulated cracked tooth.

BACKGROUND: Early clinical cracked tooth can be a perplexing disorder to diagnose and manage. One of the key problems for the diagnosis of the cracked tooth is the detection of the location of the surface crack. METHODS: This paper proposes an image-based method for the detection of the micro-crack in the simulated cracked tooth. A homemade three-axis motion platform mounted with a telecentric lens was built as an image acquisition system to observe the surface of the simulated cracked tooth, which was under compression with a magnitude of the masticatory force. By using digital image correlation (DIC), the deformation map for the crown surface of the cracked tooth was calculated. Through image analysis, the micro-crack was quantitatively visualized and characterized. RESULTS: The skeleton of the crack path was successfully extracted from the image of the principal strain field, which was further verified by the image from micro-CT. Based on crack kinematics, the crack opening displacement was quantitatively calculated to be 2-10 µm under the normal mastication stress, which was in good agreement with the value reported in the literature. CONCLUSIONS: The crack on the surface of the simulated cracked tooth could be detected based on the proposed DIC-based method. The proposed method may provide a new solution for the rapid clinical diagnosis of cracked teeth and the calculated crack information would be helpful for the subsequent clinical treatment of cracked teeth.

Electrical Resistance Prediction for Functionalized Multi-Walled Carbon Nanotubes/Epoxy Resin Composite Gasket under Thermal Creep Conditions.

Carbon nanotube-based conductive polymer composites (CPC) showed great potentials for self-sensing and in situ structural health monitoring systems. Prediction of the long-term performance for such materials would be a meaningful topic for engineering design. In this work, the changing behavior of the long-term resistance of a multi-walled carbon nanotubes/epoxy resin composite gasket was studied under different temperature and loading conditions. Glass transition strongly influenced the resistance behavior of the composite during the thermal creep process. Similar to classical Kelvin-Voigt creep model, a model considering both the destruction and recovery processes of the conductive network inside the CPC was established. The long-term resistance variation can be predicted based on the model, and the results provided here may serve as a useful guide for further design of smart engineering structural health monitoring systems.

Synthesis and potent inhibitory activities of carboxybenzyl-substituted 8-(3-(R)-aminopiperidin-1-yl)-7-(2-chloro/cyanobenzyl)-3-methyl-3,7-dihydro-purine-2,6-diones as dipeptidyl peptidase IV (DPP-IV) inhibitors.

Fourteen 3-methyl-3,7-dihydro-purine-2,6-dione derivatives 1-14 bearing carboxybenzyl and 2-chloro/cyanobenzyl groups at the N-1 and N-7 positions, respectively, were synthesized as dipeptidyl peptidase IV (DPP-IV) inhibitors. These compounds were characterized on the basis of NMR ((1)H and (13)C) and ESI MS data. In vitro bioassay indicates that most of these compounds showed moderate to good inhibitory activities against DPP-IV. Among them, compound 13 (IC50=36 nM) exhibited comparable activity with a positive control, Sitagliptin (IC50=16 nM). In addition, the structure-activity relationship of these compounds is also briefly discussed.