RESUMO
A simple method to introduce donor functions to the upper rim of self-folding benzimidazole-based deep cavitands is described. The upper rim donors allow controlled noncovalent binding of suitably sized guest species via both self-complementary hydrogen bonding and space-filling interactions, and metal-mediated self-folding is possible if bidentate coordinators are incorporated.
Assuntos
Benzimidazóis/síntese química , Éteres Cíclicos/síntese química , Resorcinóis/síntese química , Benzimidazóis/química , Cristalografia por Raios X , Éteres Cíclicos/química , Ligação de Hidrogênio , Conformação Molecular , Estrutura Molecular , Resorcinóis/químicaRESUMO
Self-folding deep cavitands embedded in a supported lipid bilayer are capable of recognizing suitably labeled proteins at the bilayer interface. The addition of a choline derived binding "handle" to a number of different proteins allows their selective noncovalent recognition, with association constants on the order of 10(5) M(-1). The proteins are displayed at the water:bilayer interface, and a single binding handle allows recognition of the large, charged protein by a small molecule synthetic receptor via complementary shape and charge interactions.