High-intensity interval training with functional electrical stimulation cycling for incomplete spinal cord injury patients: A pilot feasibility study.

BACKGROUND: Consequences of spinal cord injury (SCI) with a sedentary lifestyle will progress to muscle weakness and muscle atrophy, leading to muscle fatigue. This study aimed to determine the feasibility and preliminary effects of high-intensity interval training (HIIT) using functional electrical stimulation (FES) cycling on changes in thigh muscle volume and muscle strength, in patients with incomplete SCI. METHODS: Eight incomplete SCI patients (mean age 50 years; 6 women) with stable SCI paraplegia (mean 6.75 years since injury) participated in the HIIT FES cycling (85%-90% peak Watts; 4 × 4-min intervals) three times a week (over 6 weeks). The main outcomes were adherence, participant acceptability, and adverse events. Secondary outcomes were muscle strength (peak torque) and leg volume changes. RESULTS: Our findings revealed that the program was well-received by participants, with high levels of adherence, positive feedback, and satisfaction, suggesting that it could be a promising option for individuals seeking to enhance their lower body strength and muscle mass. Additionally, all participants successfully completed the training without any serious adverse events, indicating that the program is safe for use. Finally, we found that the 6-week HIIT FES leg cycling exercise program resulted in notable improvements in isometric peak torque of the quadriceps (range 13.9%-25.6%), hamstring muscle (18.2%-23.3%), and leg volume (1.7%-18.2%). CONCLUSIONS: This study highlights HIIT FES leg cycling exercise program potential as an effective intervention for improving lower limb muscle function.

Effects of tele-exercise training on physical and mental health and quality of life in multiple sclerosis: Do the effects differ by modality and clinical disease course?

INTRODUCTION: Tele-exercise training has improved mental and physical health and quality of life (QOL) in people with multiple sclerosis (PwMS), but there is little known about the comparability of effects across modalities and clinical disease courses. OBJECTIVE: To evaluate the effect of tele-Pilates and tele-yoga training on physical and mental factors and QOL in PwMS, with a focus on two phenotype classifications - relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS). METHODS: Eighty-two persons with RRMS (n = 48) and SPMS (n = 34) were randomly assigned into tele-Pilates (n = 29), tele-yoga (n = 26), or control (n = 27). The tele-exercis training was conducted three times per week for eight weeks. RESULTS: Significant time × group interactions were observed for QoL (p = 0.01), physical activity levels (p < 0.001), mental health (p = 0.05), and a decline in depression (p = 0.002) following tele-Pilates and tele-yoga. The corresponding subfactors, including pain, energy, emotional well-being, and role limitation due to emotional and physical problems, have shown significant improvements after interventions compared with control (all p < 0.05). The effects of exercise over control did not depend on MS phenotype (all p > 0.05). DISCUSSION: Tele-yoga and tele-Pilates exercises improved QoL and mental and physical health in PwMS, and the benefits were similar across both MS phenotypes. These findings highlight the potential of implementing tele-yoga and tele-Pilates as non-pharmacological mind-body symptomatic treatments for individuals with both RRMS and SPMS.

Effects of Tele-Pilates and Tele-Yoga on Biochemicals, Physical, and Psychological Parameters of Females with Multiple Sclerosis.

BACKGROUND: People with multiple sclerosis (PwMS) suffer from some comorbidities, including physical and psychiatric disorders, low quality of life (QoL), hormonal dysregulation, and hypothalamic-pituitary-adrenal axis dysfunction. The current study aimed to investigate the effects of eight weeks of tele-yoga and tele-Pilates on the serum levels of prolactin and cortisol and selected physical and psychological factors. METHODS: Forty-five females with relapsing remitting multiple sclerosis, based on age (18-65), expanded disability status scale (0-5.5), and body mass index (20-32), were randomly assigned to tele-Pilates, tele-yoga, or control groups (n = 15). Serum blood samples and validated questionnaires were collected before and after interventions. RESULTS: Following online interventions, there was a significant increase in the serum levels of prolactin (p = 0.004) and a significant decrease in cortisol (p = 0.04) in the time × group interaction factors. In addition, significant improvements were observed in depression (p = 0.001), physical activity levels (p < 0.001), QoL (p ≤ 0.001), and the speed of walking (p < 0.001). CONCLUSION: Our findings suggest that tele-yoga and tele-Pilates training could be introduced as patient-friendly, non-pharmacological, add-on therapeutic methods for increasing prolactin and decreasing cortisol serum levels and achieving clinically relevant improvements in depression, walking speed, physical activity level, and QoL in female MS patients.

Roles of Inorganic Oxide Based HTMs towards Highly Efficient and Long-Term Stable PSC-A Review.

In just a few years, the efficiency of perovskite-based solar cells (PSCs) has risen to 25.8%, making them competitive with current commercial technology. Due to the inherent advantage of perovskite thin films that can be fabricated using simple solution techniques at low temperatures, PSCs are regarded as one of the most important low-cost and mass-production prospects. The lack of stability, on the other hand, is one of the major barriers to PSC commercialization. The goal of this review is to highlight the most important aspects of recent improvements in PSCs, such as structural modification and fabrication procedures, which have resulted in increased device stability. The role of different types of hole transport layers (HTL) and the evolution of inorganic HTL including their fabrication techniques have been reviewed in detail in this review. We eloquently emphasized the variables that are critical for the successful commercialization of perovskite devices in the final section. To enhance perovskite solar cell commercialization, we also aimed to obtain insight into the operational stability of PSCs, as well as practical information on how to increase their stability through rational materials and device fabrication.

Cytokine Profile in Patients with Multiple Sclerosis Following Exercise: A Systematic Review of Randomized Clinical Trials.

Multiple sclerosis (MS) is one of the most prevalent causes of nontraumatic neurological impairment in young adults. This review aims to determine the impact of exercise on cytokine and adipokine profile levels as inflammatory markers in MS patients across various exercise paradigms. We used specific keywords in PubMed, Web of Science, The Cochrane Library, and Scopus to find randomized clinical trials addressing the effects of physical activity and exercise training on inflammatory markers levels in MS patients. The majority of the research showed no considerable changes in IL-6 levels, while three studies reported declining levels after the intervention. Approximately half of the trials observed a change in TNF-α and IL-10 levels after exercise interventions, while the other half showed no meaningful changes. Other markers such as IL-17, IL-4, IL-12, adipokines, and BDNF showed fluctuations in levels. We found no universal agreement on the effects of different exercise training protocols on the serum level of inflammatory markers in patients with MS. More research is needed to fully identify the effects of exercise on cytokines in MS patients.

Structural, Magnetic, and AC Measurements of Nanoferrites/Graphene Composites.

As a contribution to the graphene-based nanoferrite composites, this article is intended to present Mn, Co, and Co-Mn nanoferrites for the preparation and investigation of such samples. Nanoparticles of Co ferrite, Mn ferrite, and Co-Mn ferrite were chemically synthesized by the coprecipitation method. The composites of ferrite/graphene were made by incorporating weight ratios of 25% graphene to 75% ferrite. Various structural and characterizing investigations of ferrite samples and ferrite/graphene composites were performed, including XRD, EDX, SEM, VSM hysteresis loops, AC conductivity, and dielectric behavior. The investigations ensured the formation of the intended nanoferrite powders, each having a single-phase crystal structure with no undesired phases or elements. All samples exhibit a soft magnetic behavior. They show a semiconducting behavior of AC electrical conductivity as well. This was proved by the temperature dependence of the AC's electrical conductivity. Whereas the dielectric function and loss tangent show an expected, well-explained behavior, the ferrite/graphene composite samples have lower saturation magnetization values, lower AC conductivity, and dielectric constant values than the pure ferrites but still have the same behavior trends as those of the pure ferrites. The values obtained may represent steps on developing new materials for expected applications, such as manufacturing supercapacitors and/or improved battery electrodes.

Discovering Knee Osteoarthritis Imaging Features for Diagnosis and Prognosis: Review of Manual Imaging Grading and Machine Learning Approaches.

Knee osteoarthritis (OA) is a deliberating joint disorder characterized by cartilage loss that can be captured by imaging modalities and translated into imaging features. Observing imaging features is a well-known objective assessment for knee OA disorder. However, the variety of imaging features is rarely discussed. This study reviews knee OA imaging features with respect to different imaging modalities for traditional OA diagnosis and updates recent image-based machine learning approaches for knee OA diagnosis and prognosis. Although most studies recognized X-ray as standard imaging option for knee OA diagnosis, the imaging features are limited to bony changes and less sensitive to short-term OA changes. Researchers have recommended the usage of MRI to study the hidden OA-related radiomic features in soft tissues and bony structures. Furthermore, ultrasound imaging features should be explored to make it more feasible for point-of-care diagnosis. Traditional knee OA diagnosis mainly relies on manual interpretation of medical images based on the Kellgren-Lawrence (KL) grading scheme, but this approach is consistently prone to human resource and time constraints and less effective for OA prevention. Recent studies revealed the capability of machine learning approaches in automating knee OA diagnosis and prognosis, through three major tasks: knee joint localization (detection and segmentation), classification of OA severity, and prediction of disease progression. AI-aided diagnostic models improved the quality of knee OA diagnosis significantly in terms of time taken, reproducibility, and accuracy. Prognostic ability was demonstrated by several prediction models in terms of estimating possible OA onset, OA deterioration, progressive pain, progressive structural change, progressive structural change with pain, and time to total knee replacement (TKR) incidence. Despite research gaps, machine learning techniques still manifest huge potential to work on demanding tasks such as early knee OA detection and estimation of future disease events, as well as fundamental tasks such as discovering the new imaging features and establishment of novel OA status measure. Continuous machine learning model enhancement may favour the discovery of new OA treatment in future.

Microplastics pollution in salt pans from the Maheshkhali Channel, Bangladesh.

Microplastics (MP) were recognized as an emergent pollution problem due to their ubiquitous nature and bioaccumulative potential. Those present in salt for consumption could represent a human exposure route through dietary uptake. The current study, conducted in Bangladesh, reports microplastics contamination in coarse salt prepared for human consumption. Sea salt samples were collected from eight representative salt pans located in the country's largest salt farming area, in the Maheshkhali Channel, along the Bay of Bengal. Microplastics were detected in all samples, with mean concentrations ranging from 78 ± 9.33 to 137 ± 21.70 particles kg-1, mostly white and ranging in size from 500-1000 µm. The prevalent types were: fragments (48%) > films (22%) > fibers (15%) > granules and lines (both 9%). Fourier transform mid-IR and near-IR spectra (FT-MIR-NIR) analysis registered terephthalate (48%), polypropylene (20%), polyethylene (17%), and polystyrene (15%) in all samples. These results contribute to the MP's pollution knowledge in sea salts to understand and reduce this significant human exposure route and environmental pollution source in the future.

Degradation of Perovskite Thin Films and Solar Cells with Candle Soot C/Ag Electrode Exposed in a Control Ambient.

Perovskite solar cells (PSCs) have already achieved efficiencies of over 25%; however, their instability and degradation in the operational environment have prevented them from becoming commercially viable. Understanding the degradation mechanism, as well as improving the fabrication technique for achieving high-quality perovskite films, is crucial to overcoming these shortcomings. In this study, we investigated details in the changes of physical properties associated with the degradation and/or decomposition of perovskite films and solar cells using XRD, FESEM, EDX, UV-Vis, Hall-effect, and current-voltage (I-V) measurement techniques. The dissociation, as well as the intensity of perovskite peaks, have been observed as an impact of film degradation by humidity. The decomposition rate of perovskite film has been estimated from the structural and optical changes. The performance degradation of novel planner structure PSCs has been investigated in detail. The PSCs were fabricated in-room ambient using candle soot carbon and screen-printed Ag electrode. It was found that until the perovskite film decomposed by 30%, the film properties and cell efficiency remained stable.

Water Treatment from MB Using Zn-Ag MWCNT Synthesized by Double Arc Discharge.

A new type of nano-adsorbent zinc-silver nanoparticles ornamented by multi-walled carbon nanotubes (Zn-Ag MWCNT) was efficiently synthesized by double arc discharge using a newly designed rotating cylinder electrode. Zn-Ag MWCNT was characterized by different instrumental methods to get information about the sample shape, size, and crystallinity. Without irradiation, Zn-Ag MWCNT indicated significant potential for elimination against methylene blue (MB) which is dissolved in deionized water. When the adsorbent concentration was 0.1 g/L at normal 8 pH, the Zn-Ag MWCNTs were efficient in removing 97% of the MB from 40 mg/L that was dissolved in water for 10 min. The dye removal activity of (Zn-Ag) decorated MWCNTs was attributed to the influence of silver and zinc nanoparticles on the MWCNTs. Finally, this approach was both cost-effective and efficient.

The Promise for Reducing Healthcare Cost with Predictive Model: An Analysis with Quantized Evaluation Metric on Readmission.

Quality of care data has gained transparency captured through various measurements and reporting. Readmission measure is especially related to unfavorable patient outcomes that directly bends the curve of healthcare cost. Under the Hospital Readmission Reduction Program, payments to hospitals were reduced for those with excessive 30-day rehospitalization rates. These penalties have intensified efforts from hospital stakeholders to implement strategies to reduce readmission rates. One of the key strategies is the deployment of predictive analytics stratified by patient population. The recent research in readmission model is focused on making its prediction more accurate. As cost-saving improvements through artificial intelligent-based health solutions are expected, the broad economic impact of such digital tool remains unknown. Meanwhile, reducing readmission rate is associated with increased operating expenses due to targeted interventions. The increase in operating margin can surpass native readmission cost. In this paper, we propose a quantized evaluation metric to provide a methodological mean in assessing whether a predictive model represents cost-effective way of delivering healthcare. Herein, we evaluate the impact machine learning has had on transitional care and readmission with proposed metric. The final model was estimated to produce net healthcare savings at over $1 million given a 50% rate of successfully preventing a readmission.

Association between levels of sports participation and oral injuries among combat athletes / Associação entre níveis de participação no esporte e lesões orais em atletas de combate / Asociación entre niveles de participación en el deporte y lesiones orales en atletas de combate

ABSTRACT Introduction Oral injuries are common traumas in combat sports due to the aggressive nature of both offense and defense. Sports mouth guards are made to reduce the risk of traumatic face and jaw injuries and concussions during sports activities. Objective The objective of this study was to determine the prevalence of oral injuries in combat sports and to examine the association between participation levels and percentage of injury occurrence. Methods One hundred and eight participants (mean age: 22.42 ± 2.162 years) who were involved in sparring events were recruited. Data were collected using a questionnaire consisting of 22 questions about the demographic profile of the athletes, their injury experience and type of injuries sustained, awareness and use of mouth guards in sports activities. Descriptive analysis, Chi-square test, and one-way analysis of variance (ANOVA) were applied for data analysis. Results Almost 77% of participants had experienced oral injuries during sports activities and nearly 90% were aware that oral injuries can be reduced by using mouth guards. In addition, 52.7% of participants complained that the mouth guard is not comfortable to use during sports activities. Findings revealed a significant moderate association between levels of participation and number of oral injuries ( p = 0.013). One-way ANOVA showed a significant mean difference in the rate of oral injury for the four levels of participation groups F (3, 104) = 6.21, p = 0.011. Post-hoc comparisons using the Bonferroni test indicated a significant mean difference between university-state levels ( p = 0.033) and university-national levels ( p = 0.028). Conclusion This study revealed that higher levels of participation in sports have a higher risk of injury. It was also found that the discomfort of using a mouth guard can be reduced if the coaches make the athletes wear proper mouth guards that follow the recommended specifications. Level of evidence IIIb; Case control study.

RESUMO Introdução As lesões orais são traumas comuns nos esportes de combate, devido à natureza agressiva tanto do ataque quanto da defesa. Os protetores bucais esportivos são feitos para diminuir o risco de lesões traumáticas na face e na mandíbula; e também de concussão durante as atividades esportivas. Objetivo Este estudo teve como objetivo determinar a prevalência de lesões orais em esportes de combate e examinar a associação entre níveis de participação e a porcentagem de ocorrência de lesões. Métodos Foram recrutados cento e oito participantes (média de idade: 22,42 ± 2,162 anos) envolvidos em eventos de combate. Os dados foram coletados por meio de um questionário composto por 22 perguntas sobre o perfil demográfico dos atletas, sua experiência com lesões e tipo de lesões sofridas, conhecimento e uso de protetores bucais em atividades esportivas. A análise descritiva, o teste do qui-quadrado e a análise de variância (ANOVA) foram aplicados para análise dos dados. Resultados Quase 77% dos participantes sofreram lesões orais durante atividades esportivas e quase 90% estavam cientes de que as lesões orais podem ser reduzidas com o uso de protetores bucais. Além disso, 52,7% dos participantes reclamaram que o protetor bucal não é confortável para uso durante as atividades esportivas. Os achados revelaram associação moderada significativa entre níveis de participação e número de lesões orais (p = 0,013). A ANOVA unilateral mostrou uma diferença média significativa na taxa de lesão oral nos quatro níveis dos grupos de participação F (3, 104) = 6,21, p = 0,011. As comparações post-hoc usando o teste de Bonferroni indicaram diferença média significativa entre os níveis universitário-estadual (p = 0,033) e os níveis universitário-nacional (p = 0,028). Conclusão Este estudo revelou que níveis mais altos de participação no esporte representam maior risco de lesões. Verificou-se também que a sensação de desconforto ao usar protetor bucal pode ser reduzida se os treinadores fizerem com que os atletas usem protetores bucais adequados, que sigam as especificações recomendadas. Nível de evidência IIIb; Estudo Caso-Controle .

RESUMEN Introducción Las lesiones orales son traumas comunes en los deportes de combate, debido a la naturaleza agresiva tanto del ataque como de la defensa. Los protectores bucales deportivos son hechos para disminuir el riesgo de lesiones traumáticas en el rostro y en la mandíbula; y también de concusión en las actividades deportivas. Objetivo Este estudio tuvo como objetivo determinar la prevalencia de lesiones orales en deportes de combate y examinar la asociación entre los niveles de participación y el porcentaje de ocurrencia de lesiones. Métodos Fueron reclutados ciento ocho participantes (promedio de edad: 22,42 ± 2,162 años) involucrados en eventos de combate. Los datos fueron colectados a través de un cuestionario compuesto por 22 preguntas sobre el perfil demográfico de los atletas, su experiencia con lesiones y tipo de lesiones sufridas, conocimiento y uso de protectores bucales en actividades deportivas. El análisis descriptivo, el test de chi-cuadrado y el análisis de varianza (ANOVA) fueron aplicados para el análisis de los datos. Resultados Casi 77% de los participantes sufrió lesiones orales durante las actividades deportivas y casi 90% tenía conocimiento de que las lesiones orales pueden ser reducidas con el uso de protectores bucales. Además, 51,7% de los participantes reclamaron que el protector bucal no es confortable para uso durante las actividades deportivas. Los hallazgos revelaron asociación moderada significativa entre niveles de participación y número de lesiones orales (p = 0,013). El ANOVA unidireccional mostró una diferencia promedio significativa en la tasa de lesión oral en los cuatro niveles de grupos de participación F (3,104) = 6,21, p = 0,011. Las comparaciones post hoc usando el test de Bonferroni indicaron una diferencia promedio significativa entre los niveles universitario-estatal (p = 0,033) y los niveles universitario-nacional (p = 0,028). Conclusión Este estudio reveló que niveles más altos de participación en el deporte representan mayor riesgo de lesiones. Se verificó también que la sensación de incomodidad al usar protectores bucales adecuados puede reducirse si los entrenadores hacen con que los atletas usen protectores bucales adecuados, que sigan las especificaciones recomendadas. Nivel de evidencia IIIb; Estudio Caso-Control.

Gait analysis of national athletes after anterior cruciate ligament reconstruction following three stages of rehabilitation program: Symmetrical perspective.

This study aimed to objectively evaluate changes in gait kinematics, kinetics and symmetry among anterior cruciate ligament (ACL) reconstructed athletes during rehabilitation. Twenty-two national athletes with ACL reconstruction and 15 healthy athletes were recruited for the study. Gait data were collected between the weeks 4-5, 8-9, and 12-13 post-operation using three-dimensional motion analysis system. Five separate components, including knee range of motion (ROM), vertical ground reaction force (VGRF), their symmetries and knee extension moment were evaluated. One way and repeated measure multivariate analysis of variance (MANOVA) were used to analyze the knee ROMs. The VGRF and extension moment were tested using repeated measure ANOVA and independent sample t-test. Findings indicated significant alterations in all measured components between patients' Test 1 and control group. Repeated measure analysis revealed significant effect for time in components of knee angular and VGRF (P<0.001), their symmetry index (P=0.03) and knee extension moment (P=0.045). Univariate outcomes demonstrated significant improvement in the injured limb's stance and swing (P<0.001), and single-stance (P=0.005) ROMs over time. Symmetry indexes of stance and swing ROM, and VGRF reduced significantly by 26.3% (P=0.001), 17.9% (P<0.001), and 31.9% (P=0.03) respectively. After three months, symmetry indexes of single-stance ROM and VGRF along with operated knee extension moment were the only variables which showed significant differences with control group. The rehabilitation program allowed national athletes to restore the operated limb's gait parameters except knee extension moment by 12-13 weeks post-reconstruction; however, more time is required to normalize single-stance ROM and VGRF asymmetries.